The autophagosomal membrane becomes negatively charged during maturation due to the accumulation of PI4P, leading to the recruitment of syntaxin 17, which is required for autophagosome-lysosome fusion.
A change in the electric charge of autophagosome membranes controls the recruitment of SNARE proteins to ensure that membrane fusion occurs at the right time during autophagy.
A computational model of skeletal muscle regeneration reveals complex interplay of cytokines, angiogenesis, and cell behaviors, predicting that synergistic cytokine perturbations enhance skeletal muscle regeneration beyond individual cytokine interventions.
Alterations of DNA methylation were associated with articular cartilage degeneration in hemophilic arthropathy, and aberrant methylation and expression of TNXB promote blood-induced chondrocyte apoptosis by regulating AKT activation.
A novel role of the mitochondrial BKCa channel involves the metabolic reprogramming of breast cancer cells, facilitating their unrestricted proliferation and O2-independence, which is also of potential clinical relevance.
Advanced cryo-EM approaches reveal surprising insights into the molecular structure that allows nascent proteins to be inserted into the membrane of the endoplasmic reticulum.
Corey D Holman, Alexander P Sakers ... Patrick Seale
Single-cell expression profiling and genetic lineage analysis show that aging impairs adipocyte differentiation from precursor cells and blocks the thermogenic activation of adipocytes during cold exposure.
