Cell Biology

Cell Biology

eLife reviews research spanning vesicle transport and signal transduction to cell cycle and cell polarity and fate. Learn more about what we review and sign up for the latest content.
Illustration by Davide Bonazzi

Latest articles

    1. Cell Biology
    2. Genetics and Genomics

    A seven-sex species recognizes self and non-self mating-type via a novel protein complex

    Guanxiong Yan, Yang Ma ... Wei Miao
    A giant multifunctional protein complex mediates mating-type recognition through a non-ligand–receptor mechanism in a multisexual species.
    1. Cell Biology

    A stable microtubule bundle formed through an orchestrated multistep process controls quiescence exit

    Damien Laporte, Aurélie Massoni-Laporte ... Isabelle Sagot
    1. Cell Biology
    2. Neuroscience

    SNAP25 disease mutations change the energy landscape for synaptic exocytosis due to aberrant SNARE interactions

    Anna Kádková, Jacqeline Murach ... Jakob Balslev Sørensen
    SNAP25 disease mutations within the synaptotagmin interface impair vesicle priming and cause uncontrolled spontaneous release due to enhanced SNARE:SNARE interactions, whereas a mutation within the SNARE-bundle increases the fusion energy barrier.
    1. Cell Biology
    2. Neuroscience

    Synapsin E-domain is essential for α-synuclein function

    Alexandra Stavsky, Leonardo A. Parra-Rivas ... Daniel Gitler
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    An engineered biosensor enables dynamic aspartate measurements in living cells

    Kristian Davidsen, Jonathan S Marvin ... Lucas B Sullivan
    A genetically encoded fluorescent biosensor reveals temporally resolved changes to aspartate concentration during genetic, pharmacological, and nutritional manipulations.
    1. Cell Biology
    2. Immunology and Inflammation

    Piezo1 mechanosensing regulates integrin-dependent chemotactic migration in human T cells

    Chinky Shiu Chen Liu, Tithi Mandal ... Dipyaman Ganguly
    A hitherto unknown role of Piezo1 mechanosensors in chemotactic migration of human T cells is identified, linking focal adhesion formation to integrin recruitment.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    A TOPBP1 allele causing male infertility uncouples XY silencing dynamics from sex body formation

    Carolline Ascenção, Jennie R Sims ... Marcus B Smolka
    A Topbp1 mutant mouse reveals a non-canonical role for the ATR-TOPBP1 signaling axis in meiosis, separating ATR signaling and meiotic sex chromosome inactivation from sex body formation.
    1. Cell Biology

    Continuous endosomes form functional subdomains and orchestrate rapid membrane trafficking in trypanosomes

    Fabian Link, Alyssa Borges ... Markus Engstler
    1. Cell Biology

    Rapid binding to protofilament edge sites facilitates tip tracking of EB1 at growing microtubule plus-ends

    Samuel J Gonzalez, Julia M Heckel ... Melissa K Gardner
    Computational modeling combined with biophysical and cellular experiments reveal that rapid binding to incomplete, partial microtubule binding sites facilitates tracking of the end-binding protein EB1 with growing microtubule plus-ends.

Senior editors

  1. Felix Campelo
    The Institute of Photonic Sciences, Spain
  2. Jonathan A Cooper
    Jonathan A Cooper
    Fred Hutchinson Cancer Research Center, United States
  3. David James
    University of Sydney, Australia
  4. See more editors