Browse our latest Computational and Systems Biology articles

Systems analysis of antibody repertoires reveals that strong humoral responses lead to extensive B-cell overlap across multiple lymphoid organs, indicating physiological axes of B-cell migration and a direct correlation with antigen specificity.

Theoretical and experimental evidence that Hh signaling dynamics balances robust positioning and sharpness of different target genes in the Drosophila wing disc.

Kiss1^ARH neurons transition from synchronous to burst firing under preovulatory levels of E2, causing a shift from peptidergic to glutamatergic transmission that drives the GnRH surge through enhanced glutamate neurotransmission.

A previously unknown lipid modification by a bacterial antibiotic resistance enzyme was identified through the analysis of a family of antibiotic resistance enzyme sequences with a machine learning approach.

The perception of ambiguous steps in relative tone height is predicted by direction-selective cells in the auditory cortex, rather than the brain's represented distance between the tone heights.

Continuous attractor networks can constrain population activity to manifolds with topology radically different from that of the network architecture.

A minimal mathematical model can explain the emergence of planar cell polarity in epithelial tissues using only three free parameters, namely the rate of protein binding to cell membrane, the intracellular protein concentration, and the steepness of tissue-level gradients.

Computational modeling suggests that the BLA is capable of producing the recorded LFP rhythms via interactions of interneuron subtypes, and that those rhythms may be necessary for associative learning.

It is possible to accurately recommend antimicrobial drugs from mass spectra using neural networks and large datasets, paving the way for more efficient clinical diagnostics.