Browse our latest Computational and Systems Biology articles

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    1. Computational and Systems Biology

    Predicting ventricular tachycardia circuits in patients with arrhythmogenic right ventricular cardiomyopathy using genotype-specific heart digital twins

    Yingnan Zhang, Kelly Zhang ... Natalia A Trayanova
    A novel computational approach integrates personal genetics into personalized whole heart digital twins to predict ventricular arrhythmia circuits for patients with arrhythmogenic right ventricular cardiomyopathy.
    1. Computational and Systems Biology

    Quantitative Geometric Modeling of Blood Cells from X-ray Histotomograms of Whole Zebrafish Larvae

    Maksim A. Yakovlev, Ke Liang ... Keith C. Cheng
    Not revised
    Reviewed Preprint v1
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Inter-species association mapping links splice site evolution to METTL16 and SNRNP27K

    Matthew T Parker, Sebastian M Fica ... Gordon G Simpson
    A computational approach examines the roles of splicing factors and their association with evolutionary change in splicing.
    1. Computational and Systems Biology

    Bactabolize is a tool for high-throughput generation of bacterial strain-specific metabolic models

    Ben Vezina, Stephen C Watts ... Kelly L Wyres
    Bactabolize is a pipeline for rapid and scalable production of accurate bacterial strain-specific metabolic models and growth phenotype predictions.
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Novel discoveries and enhanced genomic prediction from modelling genetic risk of cancer age-at-onset

    Ekaterina S. Maksimova, Sven E. Ojavee ... Matthew R. Robinson
    Not revised
    Reviewed Preprint v1
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Systems level identification of a matrisome-associated macrophage polarisation state in multi-organ fibrosis

    John F Ouyang, Kunal Mishra ... Jacques Behmoaras
    A meta-analysis of single-cell data reveals an advanced and conserved polarisation state of SPP1+ macrophages in multiple human fibrotic tissues.
    1. Cell Biology
    2. Computational and Systems Biology

    Continuous sensing of nutrients and growth factors by the mTORC1-TFEB axis

    Breanne Sparta, Nont Kosaisawe ... John G Albeck
    Single-cell data on cell signaling responses to nutrient variation enable quantitative models of cellular control over protein synthesis, formalizing the concept of mTOR as a homeostatic controller of cellular metabolism.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Broad functional profiling of fission yeast proteins using phenomics and machine learning

    María Rodríguez-López, Nicola Bordin ... Jürg Bähler
    Large-scale screens and computational approaches reveal phenotypes for 3492 genes and gene-ontology predictions for 783 genes, including hitherto unstudied genes, which provides a potent platform to further dissect protein function.
    1. Neuroscience
    2. Computational and Systems Biology

    Active Dendrites Enable Robust Spiking Computations Despite Timing Jitter

    Thomas SJ Burger, Michael E Rule, Timothy O’Leary
    Not revised
    Reviewed Preprint v1
    1. Cell Biology
    2. Computational and Systems Biology

    Development and validation of a high throughput screening platform to enable target identification in skeletal muscle cells from Duchenne Muscular Dystrophy (DMD) patients

    Santosh Hariharan, Oana Lorintiu ... Nicolas Christoforou
    Not revised
    Reviewed Preprint v1
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