Developmental Biology and Stem Cells

eLife publishes research on stem cells, differentiation, tissue assembly and regeneration. Decisions are made by journal editors who are active researchers in the fields of developmental biology and stem cells.
Illustration by Davide Bonazzi

Latest articles

    1. Developmental Biology and Stem Cells

    Inter-dependent apical microtubule and actin dynamics orchestrate centrosome retention and neuronal delamination

    Ioannis Kasioulis et al.
    Microtubules are nucleated by the centrosome of the primary cilium in the apical end-foot of neuroepithelial cells and inter-dependent microtubule and actin dynamics are required here to orchestrate delamination of newborn neurons.
    1. Biochemistry
    2. Developmental Biology and Stem Cells

    The ceramide synthase 2b gene mediates genomic sensing and regulation of sphingosine levels during zebrafish embryogenesis

    Karen Mendelson et al.
    Developing oocytes lacking Sphk2 sense high sphingosine levels and transcriptionally activate expression of the gene encoding Cers2b, to mediate a salvage pathway to reduce potentially toxic sphingosine.
    1. Developmental Biology and Stem Cells

    Mouse embryonic stem cells can differentiate via multiple paths to the same state

    James Alexander Briggs et al.
    Single cell RNA sequencing reveals that mouse embryonic stem cells can be differentiated into the same terminal motor neuron state via distinct differentiation paths, one of which includes a surprising intermediate state not found in embryos.
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    Loss of foxo rescues stem cell aging in Drosophila germ line

    Filippo Artoni et al.
    Loss of foxo rescues age-related defects in stem cell-mediated regeneration post-injury.
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    Localised dynactin protects growing microtubules to deliver oskar mRNA to the posterior cortex of the Drosophila oocyte

    Ross Nieuwburg et al.
    Dynactin acts as an anti-catastrophe factor that extends microtubule growth; posteriorly elucidating a new essential step in oskar mRNA localisation and providing a novel mechanism by which motor-dependent transport can amplify the polarity of MT networks.
    1. Developmental Biology and Stem Cells

    Essential role for SUN5 in anchoring sperm head to the tail

    Yongliang Shang et al.
    SUN5 is essential for the tight junction between sperm head and the head-tail coupling apparatus, and is the main cause of human acephalic spermatozoa syndrome.
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    Planar cell polarity signaling coordinates oriented cell division and cell rearrangement in clonally expanding growth plate cartilage

    Yuwei Li et al.
    Through the interaction between PCP signaling and N-cadherin, oriented cell division and cell rearrangement are coordinated to establish the appropriate tissue architecture critical for limb skeletal morphogenesis.

Senior editors

  1. Marianne E Bronner
    Marianne E Bronner
    Senior Editor
  2. Sean Morrison
    Sean Morrison
    Senior Editor
  3. Didier Stainier
    Didier Stainier
    Senior Editor
  4. See more editors