Developmental Biology and Stem Cells

eLife publishes research on stem cells, differentiation, tissue assembly and regeneration. Decisions are made by journal editors who are active researchers in the fields of developmental biology and stem cells.
Illustration by Davide Bonazzi

Latest articles

    1. Developmental Biology and Stem Cells

    A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation

    Meng Amy Li et al.
    A novel lncRNA (Ephemeron) is connected to known post-transcriptional and epigenetic regulators as part of an integrated machinery, which controls the timely exit from the naïve state of mouse embryonic stem cells.
    1. Developmental Biology and Stem Cells

    AIRE is a critical spindle-associated protein in embryonic stem cells

    Bin Gu et al.
    AIRE played novel roles in the mitosis process in embryonic stem cells and early embryo cells.
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    Dpp controls growth and patterning in Drosophila wing precursors through distinct modes of action

    Pablo Sanchez Bosch et al.
    Striped expression of Dpp in Drosophila wing precursors leads to graded signalling activity that positions wing veins and, in parallel, promotes growth in a gradient-independent manner by supplying signalling activity above a threshold.
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    Dpp from the anterior stripe of cells is crucial for the growth of the Drosophila wing disc

    Shinya Matsuda, Markus Affolter
    A recent report proposing that the dpp stripe (the main source of the protein dpp) is dispensable for Drosophila wing disc growth missed the critical role on growth due to imprecise spatial removal of dpp.
    1. Developmental Biology and Stem Cells

    Boundary Dpp promotes growth of medial and lateral regions of the Drosophila wing

    Lara Barrio, Marco Milán
    Dpp emanating from the anterior-posterior compartment boundary is continuously required to promote proliferative growth of the whole fly wing appendage.
    1. Developmental Biology and Stem Cells

    Germ cell connectivity enhances cell death in response to DNA damage in the Drosophila testis

    Kevin L Lu, Yukiko M Yamashita
    Genetic and cell biological study indicates that germ cells' connectivity serves as a mechanism to increase the sensitivity of germline to DNA damage, protecting the genome of gametes, in the Drosophila testis.
    1. Developmental Biology and Stem Cells
    2. Human Biology and Medicine

    Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids

    Marko Z Nikolić et al.
    Improved characterisation of human embryonic lung development highlights human-mouse differences and facilitates the development of defined culture conditions for the expansion of self-renewing, multipotent human lung epithelial progenitor cells.
    1. Developmental Biology and Stem Cells
    2. Human Biology and Medicine

    Organ Development: Tips from the embryonic lung

    Avinash Waghray, Jayaraj Rajagopal
    A new source of progenitor cells can now be used to study hidden aspects of human lung development and pediatric lung disease.
    Insight
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    1. Developmental Biology and Stem Cells
    2. Genomics and Evolutionary Biology

    Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in mouse embryonic stem cells

    Marie MacLennan et al.
    Post-translational regulation of retrotransposons plays a key role in preventing retrotransposon mobilization in the epigenetically dynamic mouse germline.
    1. Developmental Biology and Stem Cells
    2. Genomics and Evolutionary Biology

    Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression

    Daniel Andergassen et al.
    Allele-specific expression due to genetic differences, X-chromosome inactivation or genomic imprinting, varies dynamically throughout development, and may be explained by allele-specific differences in stability or the actions of tissue-specific enhancers.

Senior editors

  1. Marianne E Bronner
    Marianne E Bronner
    Senior Editor
  2. Didier Stainier
    Didier Stainier
    Senior Editor
  3. K VijayRaghavan
    K VijayRaghavan
    Senior Editor
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