Developmental Biology and Stem Cells

eLife publishes research on stem cells, differentiation, tissue assembly and regeneration. Decisions are made by journal editors who are active researchers in the fields of developmental biology and stem cells.

Latest articles

    1. Biochemistry
    2. Developmental Biology and Stem Cells

    Poly(A) tail length regulates PABPC1 expression to tune translation in the heart

    Sandip Chorghade et al
    A poly(A) tail-based regulatory mechanism dynamically controls PABPC1 protein synthesis in cardiomyocytes and thereby titrates cellular translation in response to developmental and hypertrophic cues.
    Research Article
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    1. Cell Biology
    2. Developmental Biology and Stem Cells

    Lineage commitment of embryonic cells involves MEK1-dependent clearance of pluripotency regulator Ventx2

    Pierluigi Scerbo et al.
    Degradation and asymmetric inheritance during cell division of a core pluripotency regulator contributes to lineage commitment in the early Xenopus embryo.
    Research Article
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    1. Biochemistry
    2. Developmental Biology and Stem Cells

    Cardiac Hypertrophy: A tail of translational regulation

    Gillian A Gray, Nicola K Gray
    An RNA-binding protein called PABPC1 has an important role in determining protein synthesis rates and hypertrophy in the heart.
    Insight
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    1. Cell Biology
    2. Developmental Biology and Stem Cells

    Organ sculpting by patterned extracellular matrix stiffness

    Justin Crest et al.
    1. Developmental Biology and Stem Cells
    2. Neuroscience

    Signalling through AMPA receptors on oligodendrocyte precursors promotes myelination by enhancing oligodendrocyte survival

    Eleni Kougioumtzidou et al.
    Electrically active axons in white matter stimulate their own myelination by releasing glutamate, which signals through AMPA-type glutamate receptors on nearby oligodendrocyte precursors and newly-differentiating oligodendrocytes, enhancing their survival and hence their ability to myelinate.
    Research Article Updated
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    1. Cell Biology
    2. Developmental Biology and Stem Cells

    Transcription factor TFCP2L1 patterns cells in the mouse kidney collecting ducts

    Max Werth et al.
    A combination of genetic and molecular assays revealed that transcription factor Tfcp2l1 provides the basis for cell patterning and physiologic coordination in kidney collecting ducts.
    Research Article Updated
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    1. Developmental Biology and Stem Cells

    Cutting Edge: Promoting international collaboration and creativity in doctoral students

    Christopher M Groen et al
    Staff from the Mayo Clinic in the US and the Karolinska Institute in Sweden describe a joint transatlantic course intended to broaden the horizons of the next generation of researchers in the field of regenerative medicine.
    Feature Article
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    1. Developmental Biology and Stem Cells
    2. Neuroscience

    Genetic specification of left–right asymmetry in the diaphragm muscles and their motor innervation

    Camille Charoy et al
    Analysis of embryonic mouse diaphragm reveals muscle and nerve left–right asymmetries set by a Nodal-dependent genetic cascade, which imprints different molecular signatures to left and right motoneurons that shape their innervation pattern.
    Research Article
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    1. Developmental Biology and Stem Cells

    A vitamin-B2-sensing mechanism that regulates gut protease activity to impact animal’s food behavior and growth

    Bin Qi et al
    The availability of an essential dietary micronutrient is evaluated by an intestinal signaling system that in turn regulates food-uptake and response behaviors by modulating protease expression.
    Research Article Updated
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