Browse our latest Developmental Biology articles

Page 80 of 210
    1. Developmental Biology

    An adhesion G protein-coupled receptor is required in cartilaginous and dense connective tissues to maintain spine alignment

    Zhaoyang Liu, Amro A Hussien ... Ryan S Gray
    The regulation of the biomechanical properties of tendons/ligaments is essential for the maintenance of spine alignment in the mouse.
    1. Developmental Biology
    2. Genetics and Genomics

    Epi-mutations for spermatogenic defects by maternal exposure to di(2-ethylhexyl) phthalate

    Yukiko Tando, Hitoshi Hiura ... Yasuhisa Matsui
    Gene analyses reveal the abnormal DNA methylation and expression of the genes essential for spermatogenesis as a cause of spermatogenic defects in offspring induced by maternal exposure of a chemical.
    1. Developmental Biology
    2. Immunology and Inflammation

    Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β−selection

    Xia Liu, Jingjing Yu ... Xi Chen
    Endoplasmic reticulum-associated degradation (ERAD) is a critical protein quality control checkpoint for thymocyte β-slection.
    1. Cell Biology
    2. Developmental Biology

    The GNU subunit of PNG kinase, the developmental regulator of mRNA translation, binds BIC-C to localize to RNP granules

    Emir E Avilés-Pagán, Masatoshi Hara, Terry L Orr-Weaver
    The Drosophila PNG kinase controls mRNA translation at the oocyte-to-embryo transition, and its GNU activating subunit is shown here to bind translational repressors and be a component of RNP granules.
    1. Developmental Biology

    Chondrocytes in the resting zone of the growth plate are maintained in a Wnt-inhibitory environment

    Shawn A Hallett, Yuki Matsushita ... Noriaki Ono
    Slow-cycling chondrocytes are maintained in a Wnt-inhibitory environment within the resting zone, unraveling a novel mechanism regulating maintenance and differentiation of parathyroid hormone-related protein (PTHrP)-expressing skeletal stem cells of the postnatal growth plate.
    1. Cancer Biology
    2. Developmental Biology

    E2F/Dp inactivation in fat body cells triggers systemic metabolic changes

    Maria Paula Zappia, Ana Guarner ... Maxim V Frolov
    The E2F/Dp transcription factors, which are key cell cycle regulators, can also mediate the regulation of carbohydrate metabolism in larva by controlling both systemic trehalose homeostasis and fat storage.
    1. Developmental Biology
    2. Genetics and Genomics

    Somatic aging pathways regulate reproductive plasticity in Caenorhabditis elegans

    Maria C Ow, Alexandra M Nichitean, Sarah E Hall
    Somatic aging and germline RNAi pathways promote inheritance of ancestral starvation memory through reallocation of fat storage in Caenorhabditis elegans.
    1. Cell Biology
    2. Developmental Biology

    Reduced synchroneity of intra-islet Ca2+ oscillations in vivo in Robo-deficient β cells

    Melissa T Adams, JaeAnn M Dwulet ... Barak Blum
    Synchronized β cell response to glucose is lost concomitant with loss of islet architecture in Robo-deficient islets of Langerhans in vivo.
    1. Developmental Biology
    2. Evolutionary Biology

    Cortex cis-regulatory switches establish scale colour identity and pattern diversity in Heliconius

    Luca Livraghi, Joseph J Hanly ... Chris D Jiggins
    The evolution of a butterfly mimetic phenotype is driven by modular cis-regulstory switches controlling a ‘hotspot’ gene.
    1. Developmental Biology

    Pak1 and PP2A antagonize aPKC function to support cortical tension induced by the Crumbs-Yurt complex

    Cornelia Biehler, Katheryn E Rothenberg ... Patrick Laprise
    Cell biology analyses in Drosophila epithelial tissues reveal novel mechanisms connecting epithelial polarity proteins with Myosin-dependent cell contractility.