Browse our latest Genetics and Genomics articles

The genomic response of endothelial cells to hypoxia via MOA-seq transcription factor occupancy profiling identified known and novel HIF1A-associated and independent cis-regulatory elements, which defined ten distinct hypoxic kinetic clusters.

DNA-methylation-based predictors of biological age often fail to generalize across human populations, limiting their utility as biomarkers of aging and disease.

A time-dependent genetic interaction between the µ opioid receptor and genes drives early morphine responses in mice, highlighting pathways linked to human substance use disorder.

A single-cell multiomic technique measuring both transcription and chromatin accessibility in the same cell.

Stable allele-specific epigenetic regulation creates cellular mosaicism of numerous autosomal dosage-sensitive genes involved in human neurological and developmental disorders.

Genes associated with male reproductive biology appear to be under relaxed selective constraint in a primate species with low sperm competition.

Nickase and nuclease Prime Editors offer complementary routes for precise zebrafish genome editing, balancing accuracy for substitutions with efficiency for short insertions.