Browse our latest Genetics and Genomics articles

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    1. Genetics and Genomics

    ZC3H11A mutations cause high myopia by triggering PI3K-AKT and NF-κB-mediated signaling pathway in humans and mice

    Chong Chen, Qian Liu ... Xinting Liu
    The unbiased genetic screening and animal model experiments have characterized a new candidate pathogenic gene associated with high myopia, providing a potential therapeutic intervention target for controlling the disease.
    1. Genetics and Genomics
    2. Neuroscience

    The hypoxic response extends lifespan through a bioaminergic and peptidergic neural circuit

    Elizabeth S Kitto, Shijiao Huang ... Scott F Leiser
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    1. Genetics and Genomics
    2. Neuroscience

    Transcriptional responses to chronic oxidative stress require cholinergic activation of G-protein-coupled receptor signaling

    Kasturi Biswas, Caroline Moore ... Michael M Francis
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Genetics and Genomics
    2. Evolutionary Biology

    Faroese Whole Genomes Provide Insight into Ancestry and Recent Selection

    Iman Hamid, Ólavur Mortensen ... Noomi O Gregersen
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Genetics and Genomics
    2. Epidemiology and Global Health

    Heterogenous associations of polygenic indices of 35 traits with mortality

    Hannu Lahtinen, Jaakko Kaprio ... Pekka Martikainen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Benchmarking and optimization of methods for the detection of identity-by-descent in high-recombining Plasmodium falciparum genomes

    Bing Guo, Shannon Takala-Harrison, Timothy D O'Connor
    hmmIBD outperforms alternative tools in detecting genome segments that are identical-by-descent and uncovering signals of positive selection and demographic history in malaria parasite genomes, underscoring the importance of tool prioritization and optimization for reliable malaria genomic surveillance.
    1. Genetics and Genomics

    Optimised genome editing for precise DNA insertion and substitution using Prime Editors in zebrafish

    Yosuke Ono, Martin Peterka ... Steffen Scholpp
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Developmental Biology
    2. Genetics and Genomics

    Computer prediction and genetic analysis identifies retinoic acid modulation as a driver of conserved longevity pathways in genetically-diverse Caenorhabditis nematodes

    Stephen A Banse, Christine A Sedore ... Patrick C Phillips
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Genetics and Genomics

    Chromosome-scale genome assembly of the European common cuttlefish Sepia officinalis

    Simone Rencken, Georgi Tushev ... Gilles Laurent
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Genetics and Genomics
    2. Neuroscience

    The C. elegans gustatory receptor homolog LITE-1 is a chemoreceptor required for diacetyl avoidance

    Alan Koh, Eduard Bokman ... André EX Brown
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
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