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    1. Computational and Systems Biology
    2. Genetics and Genomics

    Wnt Signaling: Exploring the origins of a signaling pathway

    Balaji Santhanam
    The 19 Wnt proteins found in humans are part of a larger superfamily of proteins that are also found in Archaea and Bacteria.
    Version of Record
    Insight
    1. Cell Biology
    2. Genetics and Genomics

    Impact of maximal overexpression of a non-toxic protein on yeast cell physiology

    Yuri Fujita, Shotaro Namba ... Hisao Moriya
    A neutrality index identifies mox-YG as a minimally cytotoxic protein, enabling ultra-high expression and uncovering key physiological consequences of protein burden.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Fast evolutionary turnover and overlapping variances of sex-biased gene expression patterns defy a simple binary sex classification of somatic tissues

    Chen Xie, Sven Künzel, Diethard Tautz
    Sex-biased gene expression in the body organs evolves rapidly, supporting a mosaic model of maleness and femaleness across tissues and thus challenging binary views of sex characteristics in mammals.
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Massively Parallel Polyribosome Profiling Reveals Translation Defects of Human Disease-Relevant UTR Mutations

    Wei-Ping Li, Jia-Ying Su ... Chien-Ling Lin
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Evolutionary Biology
    2. Genetics and Genomics

    Ancient trans-species polymorphism at the Major Histocompatibility Complex in primates

    Alyssa Lyn Fortier, Jonathan K Pritchard
    Trans-species polymorphism at primate Major Histocompatibility Complex genes is old, especially in the 'classical' genes, while rapidly-evolving regions of each gene correspond with proteins' functional domains.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Modeling metabolic disease susceptibility and resilience in genetically diverse mice

    Candice N Baker, Jeffrey M Harder ... Gary A Churchill
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Compelling
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Genome reorganization and its functional impact during breast cancer progression

    Kathleen S Metz Reed, Andrew Fritz ... Tom Misteli
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    1. Developmental Biology
    2. Genetics and Genomics

    A genome-wide MAGIC kit for recombinase-independent mosaic analysis in Drosophila

    Yifan Shen, Ann T Yeung ... Chun Han
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Inhibition of the UFD-1-NPL-4 complex triggers an aberrant immune response in Caenorhabditis elegans

    Rajneesh Rao, Alejandro Aballay, Jogender Singh
    Inhibition of the UFD-1-NPL-4 complex activates immune responses in Caenorhabditis elegans that reduce gut pathogen load but simultaneously compromise host survival.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Regulatory networks of KRAB zinc finger genes and transposable elements changed during human brain evolution and disease

    Yao-Chung Chen, Arnaud Maupas, Katja Nowick
    Primate cross-species analysis of interactions between transposable elements and KRAB-ZNF genes with the new TEKRABber tool highlights human-specific interactions with potential relevance to Alzheimer’s disease.
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