Browse our latest Genetics and Genomics articles

Page 7 of 153
    1. Developmental Biology
    2. Genetics and Genomics

    Ripply1 and Gsc collectively suppress anterior endoderm differentiation from prechordal plate progenitors

    Tao Cheng, Xiang Liu ... Peng-Fei Xu
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Cell type-specific network analysis in Diversity Outbred mice identifies genes potentially responsible for human bone mineral density GWAS associations

    Luke J Dillard, Gina Calabrese ... Charles Farber
    Single-cell transcriptomics data from mouse bone-relevant cells was used to inform human bone mineral density genome-wide association studies and prioritize genetic targets with potential causal roles in the development of osteoporosis.
    1. Developmental Biology
    2. Genetics and Genomics

    A genome-wide MAGIC kit for recombinase-independent mosaic analysis in Drosophila

    Yifan Shen, Ann T Yeung ... Chun Han
    A comprehensive toolkit enables genome-wide, recombinase-independent mosaic analysis in Drosophila, permitting clonal analysis of pericentromeric genes, deficiency chromosomes, and interspecific hybrids previously inaccessible to standard methods.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    EPB41L4A-AS1 long noncoding RNA acts in both cis- and trans-acting transcriptional regulation and controls nucleolar biology

    Alan Monziani, Juan Pablo Unfried ... Igor Ulitsky
    EPB41L4A-AS1, a highly expressed snoRNA host long noncoding RNA, has multiple functions, positive regulation in cis of the EPB41L4A gene and a trans-acting role in supporting proper nucleolar biology.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Defining the chromatin-associated protein landscapes on Trypanosoma brucei repetitive elements using synthetic TALE proteins

    Roberta Carloni, Tadhg Devlin ... Robin C Allshire
    Synthetic proteins designed to bind specific repetitive DNA sequences in the Trypanosoma brucei genome allow the identification of proteins enriched over different DNA elements.
    1. Developmental Biology
    2. Genetics and Genomics

    Nup107 is a crucial regulator of torso-mediated metamorphic transition in Drosophila melanogaster

    Jyotsna Kawadkar, Pradyumna Ajit Joshi, Ram Kumar Mishra
    Y-complex nucleoporin, Nup107, can regulate ecdysone production by affecting the transcription of Halloween genes and levels of RTK receptor, torso, for the metamorphic transition from larva to pupa.
    1. Developmental Biology
    2. Genetics and Genomics

    Drosophila melanogaster model of RVCL-S demonstrates age dependent disease progression

    Elena Gracheva, Abigail Matt ... Chao Zhou
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Computational and Systems Biology
    2. Genetics and Genomics

    JAX Animal Behavior System (JABS), a genetics-informed, end-to-end advanced behavioral phenotyping platform for the laboratory mouse

    Anshul Choudhary, Brian Q Geuther ... Vivek Kumar
    The JAX Animal Behavior System integrates standardized hardware, machine learning methods, and annotated datasets to enable reproducible behavioral phenotyping and genetic analysis across diverse mouse strains.
    1. Cell Biology
    2. Genetics and Genomics

    Non-visual light modulates behavioral memory and gene expression in Caenorhabditis elegans

    Zhijian Ji, Bingying Wang ... Dengke K Ma
    Visible light engages a non-visual, bZIP-dependent transcriptional pathway in peripheral tissues that communicates with the nervous system to shape behavioral plasticity and memory, enabling optogenetic-like gene control without photoreceptors.
    Version of Record
    Short Report
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Virus Evolution: Scaling up efforts to target evolving viruses

    Lin Wang, Henrik Salje
    High-throughput neutralisation tests could lead to a better understanding of the evolution of human influenza.
    Version of Record
    Insight