In a randomized trial, ART intensification by doubling the dolutegravir dosage in people with HIV stably suppressed on dolutegravir-based ART reduced levels of four HIV reservoir markers in peripheral blood.
Trained immunity enhances innate immune responses, yet a Western lifestyle may lead to maladaptive trained immunity and drive non-communicable diseases.
Trained immunity provides a unifying framework linking innate immune memory to both protective and maladaptive inflammation across neurological diseases, offering new insights into disease mechanisms and potential therapeutic strategies.
Michaela T Reichmann, Liku B Tezera ... Paul T Elkington
The deep evolutionary relationship between humans and Mycobacterium tuberculosis suggests latent infection may confer benefit, with important consequences for investigating and interpreting host–pathogen interactions.
Antigen-driven TCR signaling in the epidermis during CD8+ TRM differentiation results in a lower TGFβ requirement for persistence and increased proliferative capacity that together enhance epidermal TRM fitness.
Increased fucosylated IgG and reduced bisecting GlcNAc during HTNV convalescence may promote rapid recovery from hemorrhagic fever with renal syndrome.
Alina Xiaoyu Yang, Lisa Ramos-Rodriguez ... Yang Zhou
PLSCR1 is an IFN-λ-stimulated gene that enhances IFN-λR1 expression at both transcriptional and protein level, highlighting the potential for targeting PLSCR1 pathways in anti-influenza therapy.
