Browse our latest Immunology and Inflammation articles

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    1. Cancer Biology
    2. Immunology and Inflammation

    Decoupled neoantigen cross-presentation by dendritic cells limits anti-tumor immunity against tumors with heterogeneous neoantigen expression

    Kim Bich Nguyen, Malte Roerden ... Stefani Spranger
    In vivo modeling of neoantigen-restricted heterogeneity shows that clonal expression of neoantigens enhances anti-tumor T cell responses by increasing the stimulatory capacity of dendritic cells in the lymph node.
    1. Cell Biology
    2. Immunology and Inflammation

    Paradox Found: Global Accounting of Lymphocyte Protein Synthesis

    Mina O. Seedhom, Devin Dersh ... Jonathan W. Yewdell
    1. Immunology and Inflammation
    2. Neuroscience

    TPL2 kinase activity regulates microglial inflammatory responses and promotes neurodegeneration in tauopathy mice

    Yuanyuan Wang, Tiffany Wu ... Jesse E Hanson
    Preventing activity of the kinase tumor progression locus 2 modulates microglial activation, reduces T-cell brain infiltration, and is neuroprotective in disease models.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    p38γ and p38δ modulate innate immune response by regulating MEF2D activation

    Alejandra Escós, Ester Diaz-Mora ... Ana Cuenda
    Generation and validation of a new mouse strain as a tool to demonstrate the implication of p38γ/p38δ in inflammation through the regulation of the transcription factor MEF2D’s activity.