Browse our latest Immunology and Inflammation articles

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    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Tissue-resident memory CD4+ T cells are sustained by site-specific levels of self-renewal and continuous replacement

    Jodie Chandler, M Elise Bullock ... Andrew J Yates
    Memory CD4 T cells within tissues are highly dynamic, and their continuous replacement may erode immunity to previous infections.
    1. Immunology and Inflammation

    Hypothermia protects against ventilator-induced lung injury by limiting IL-1β release and NETs formation

    Nobuyuki Nosaka, Vanessa Borges ... Kenichi Shimada
    Therapeutic hypothermia mitigates ventilator-induced lung injury by suppressing macrophage-derived IL-1β release, thereby reducing neutrophil extracellular trap formation, vascular leakage, and hypoxemia in a two-hit acute lung injury model.
    1. Immunology and Inflammation

    Trained immunity: A new player in cancer immunotherapy

    Shu Li, Yi Zou ... Jun Yan
    Trained immunity is a form of innate immune cell memory that is being developed as a novel immunotherapeutic approach for cancer treatment.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    CARD8 inflammasome activation during HIV-1 cell-to-cell transmission

    Jessie Kulsuptrakul, Michael Emerman, Patrick S Mitchell
    During cell-to-cell spread, HIV-1 protease activity triggers CARD8 inflammasome activation and IL-1β release from macrophages, which may contribute to inflammation and chronic immune activation.
    1. Immunology and Inflammation

    Susceptibility of Kit-mutant mice to sepsis caused by enteral dysbiosis, not mast cell deficiency

    Thorsten B Feyerabend, Fabienne Schochter ... Hans-Reimer Rodewald
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Immunology and Inflammation

    Layers of immunity: Deconstructing the Drosophila effector response

    Faustine Ryckebusch, Yao Tian ... Bruno Lemaitre
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Immunology and Inflammation

    Class A Scavenger Receptor MARCO negatively regulates Ace expression and aldosterone production

    Conan JO O’Brien, Giorgio Ratti ... Ana I Domingos
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Incomplete
    1. Immunology and Inflammation

    Interferon Signaling: Immobilizing bacteria to prevent infections

    Patricia Reist Iscar, Petr Broz
    The interferon-induced GTPase GVIN1 prevents bacteria from spreading among cells by coating them and rendering them immobile.
    Version of Record
    Insight
    1. Immunology and Inflammation

    Temperature-based MHC class-I multimer peptide exchange for human HLA-A, B and C

    Cilia R Pothast, Ian Derksen ... Ferenc A Scheeren
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Evolutionary Biology
    2. Immunology and Inflammation

    Evolutionary and functional analyses reveal a role for the RHIM in tuning RIPK3 activity across vertebrates

    Elizabeth J Fay, Kolya Isterabadi ... Matthew D Daugherty
    Combining phylogenetic analyses and functional assays to study the receptor interacting protein kinase family reveals conserved and non-conserved functions in immune signaling across vertebrates.
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