Kim Bich Nguyen, Malte Roerden ... Stefani Spranger
In vivo modeling of neoantigen-restricted heterogeneity shows that clonal expression of neoantigens enhances anti-tumor T cell responses by increasing the stimulatory capacity of dendritic cells in the lymph node.
Preventing activity of the kinase tumor progression locus 2 modulates microglial activation, reduces T-cell brain infiltration, and is neuroprotective in disease models.
Generation and validation of a new mouse strain as a tool to demonstrate the implication of p38γ/p38δ in inflammation through the regulation of the transcription factor MEF2D’s activity.
