Browse our latest Immunology and Inflammation articles

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    1. Immunology and Inflammation

    The interferon-rich skin environment regulates Langerhans cell ADAM17 to promote photosensitivity in lupus

    Thomas Morgan Li, Victoria Zyulina ... Theresa T Lu
    Interferon contributes to photosensitivity at least in part by causing Langerhans cell ADAM17 dysfunction, raising the possibility that anifrolumab ameliorates lupus skin disease in part by restoring Langerhans cell function.
    1. Immunology and Inflammation

    Self-inhibiting percolation and viral spreading in epithelial tissue

    Xiaochan Xu, Bjarke Frost Nielsen, Kim Sneppen
    A gene expression data-informed model reveals that a small fraction of interferon-producing cells can effectively constrain early virus spread in epithelial tissue, elucidating connections between critical dynamics and infection heterogeneity.
    1. Immunology and Inflammation

    Elevated glycolytic metabolism of monocytes limits the generation of HIF1A-driven migratory dendritic cells in tuberculosis

    Mariano Maio, Joaquina Barros ... Luciana Balboa
    A newly identified immunometabolic mechanism clarifies the aberrant trafficking of dendritic cells to lymph nodes in tuberculosis.
    1. Immunology and Inflammation

    T follicular helper cell profiles differ by malaria antigen and for children compared to adults

    Catherine S. Forconi, Christina Nixon ... Ann M. Moormann
    1. Immunology and Inflammation
    2. Neuroscience

    Spontaneous human CD8 T cell and autoimmune encephalomyelitis-induced CD4/CD8 T cell lesions in the brain and spinal cord of HLA-DRB1*15-positive multiple sclerosis humanized immune system mice

    Irini Papazian, Maria Kourouvani ... Lesley Probert
    Severely immunodeficient B2m-NOG mice transplanted with human peripheral blood mononuclear cells from multiple sclerosis patients partially reproduce disease immunopathology and represent novel experimental models for studying human immune responses to the central nervous system in a rapid and personalized manner.