Immunology and Inflammation

Immunology and Inflammation

eLife publishes research spanning allergy, immunity and immunoregulation, inflammation and T-cell receptor signalling. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Immunology and Inflammation

    Memory persistence and differentiation into antibody-secreting cells accompanied by positive selection in longitudinal BCR repertoires

    Artem Mikelov, Evgeniia I Alekseeva ... Ivan V Zvyagin
    High degree of clonal persistence and excess of inter-individual convergence are observed in human memory B cell repertoires, along with signatures of both negative and positive selection in most abundant clonal lineages.
    1. Immunology and Inflammation

    A neutrophil–B-cell axis impacts tissue damage control in a mouse model of intraabdominal bacterial infection via Cxcr4

    Riem Gawish, Barbara Maier ... Sylvia Knapp
    LPS pre-exposure is tissue protective during a subsequent lethal E. coli peritonitis by long-term modulation the bone marrow B-cell and neutrophil pool which affects neutrophil tissue damaging properties and therapeutic activation of Cxcr4 promotes tissue damage control during sepsis.
    1. Immunology and Inflammation
    2. Medicine

    Neutrophil-mediated fibroblast-tumor cell il-6/stat-3 signaling underlies the association between neutrophil-to-lymphocyte ratio dynamics and chemotherapy response in localized pancreatic cancer: A hybrid clinical-preclinical study

    Iago de Castro Silva, Anna Bianchi ... Jashodeep Datta
    A neutrophil-CAF-tumor cell IL-1β/IL-6/STAT-3 signaling axis in the pancreatic tumor microenvironment underlies the association between neutrophil-to-lymphocyte ratio dynamics and pathologic response in patients with pancreatic ductal adenocarcinoma undergoing neoadjuvant therapy.
    Short Report Updated
    Formats available:
    • HTML
    • PDF
    1. Immunology and Inflammation
    2. Medicine

    Bone marrow adipocytes drive the development of tissue invasive Ly6Chigh monocytes during obesity

    Parastoo Boroumand, David C Prescott ... Amira Klip
    Diet-induced obesity in mice led to a duration of diet-dependent bone marrow adipocyte whitening, which drove monocyte expansion and skewing towards a tissue-invasive phenotype, likely contributing to ensuing tissue infiltration that accompanies obesity and diabetes.
    1. Cell Biology
    2. Immunology and Inflammation

    A crosstalk between hepcidin and IRE/IRP pathways controls ferroportin expression and determines serum iron levels in mice

    Edouard Charlebois, Carine Fillebeen ... Kostas Pantopoulos
    Under systemic iron overload, translational derepression of ferroportin mRNA via the IRE/IRP system antagonizes hepcidin-mediated ferroportin degradation to coordinately control serum iron.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    Mechanism of bisphosphonate-related osteonecrosis of the jaw (BRONJ) revealed by targeted removal of legacy bisphosphonate from jawbone using competing inert hydroxymethylene diphosphonate

    Hiroko Okawa, Takeru Kondo ... Ichiro Nishimura
    The targeted removal of legacy bisphosphonate from the jawbone by competitive equilibrium therapy not only elucidated the pathological mechanism of bisphosphonate-related osteonecrosis of the jaw (BRONJ) but also established a highly translatable therapeutic option for BRONJ.
    1. Cancer Biology
    2. Immunology and Inflammation

    Transient cell-in-cell formation underlies tumor relapse and resistance to immunotherapy

    Amit Gutwillig, Nadine Santana-Magal ... Yaron Carmi
    Tumors escape killing by the immune system through generating transient spatial cell-in-cell structures that are impenetrable to cytotoxic compounds including lytic granules and chemotherapy.

Senior editors

  1. Arturo Casadevall
    Johns Hopkins Bloomberg School of Public Health, United States
  2. Betty Diamond
    The Feinstein Institute for Medical Research, United States
  3. Tadatsugu Taniguchi
    Tadatsugu Taniguchi
    Research Center for Advanced Science and Technology, The University of Tokyo, Japan
  4. See more editors