Immunology and Inflammation

Latest articles

1. 1. Immunology and Inflammation

   Selective loss of CD107a TIGIT+ memory HIV-1-specific CD8+ T cells in PLWH over a decade of ART

   Oscar Blanch-Lombarte, Dan Ouchi ... Julia G Prado

   PLWH over a decade of ART showed a significant reshaping of the function and expression of inhibitory receptors across the CD8+ T cell landscape, ultimately leading to a decrease of CD107a TIGIT HIV-1-specific CD8+ T cells recovered by TIGIT blockade.
2. 1. Genetics and Genomics
   2. Immunology and Inflammation

   Epigenetic signature of human immune aging in the GESTALT study

   Roshni Roy, Pei-Lun Kuo ... Luigi Ferrucci

   Identification of human DNA sites differentially methylated with aging across six different primary immune cells suggests that the sensing of hypoxia drives the epigenetic clock.
3. 1. Immunology and Inflammation

   ER-to-lysosome Ca²⁺ refilling followed by K⁺ efflux-coupled store-operated Ca²⁺ entry in inflammasome activation and metabolic inflammation

   Hyereen Kang, Seong Woo Choi ... Myung-Shik Lee
4. 1. Developmental Biology
   2. Immunology and Inflammation

   Inhibition of Notch activity by phosphorylation of CSL in response to parasitization in Drosophila

   Sebastian Deichsel, Lisa Frankenreiter ... Anja C. Nagel
5. 1. Immunology and Inflammation
   2. Neuroscience

   Molecular consequences of peripheral Influenza A infection on cell populations in the murine hypothalamus

   René Lemcke, Christine Egebjerg ... Birgitte R Kornum

   Identification of transcriptional changes in the hypothalamus during Influenza A virus infection enhances our understanding of mechanisms underlying long-lasting neurological disturbances, potentially informing future therapeutic interventions and improving patient outcomes.
6. 1. Immunology and Inflammation

   SPOP targets the immune transcription factor IRF1 for proteasomal degradation

   Irene Schwartz, Milica Vunjak ... Gijs A Versteeg

   SPOP-dependent degradation of interferon regulatory factor 1 curtails cell-intrinsic innate immunity, thereby contributing to immune resolution.
7. 1. Immunology and Inflammation

   Differences in the inflammatory proteome of East African and Western European adults and associations with environmental and dietary factors

   Godfrey S Temba, Nadira Vadaq ... Quirijn de Mast

   Comparing the inflammatory proteome of healthy Tanzanian and Dutch adults highlights a pro-inflammatory phenotype and metabolic differences in Tanzanians, with the potential role of food-derived metabolites in driving inflammation.
8. 1. Genetics and Genomics
   2. Immunology and Inflammation

   Polymorphisms in Intron 1 of HLA-DRA Differentially Associate with Type 1 Diabetes and Celiac Disease and Implicate Involvement of Complement System Genes C4A and C4B

   Özkan Aydemir, Jeffrey A. Bailey ... TEDDY Study Group
9. 1. Immunology and Inflammation

   Vaccination with mycobacterial lipid loaded nanoparticle leads to lipid antigen persistence and memory differentiation of antigen-specific T cells

   Eva Morgun, Jennifer Zhu ... Chyung-Ru Wang
10. 1. Immunology and Inflammation

    Leucine alleviates cytokine storm syndrome by regulating macrophage polarization via the mTORC1/LXRα signaling pathway

    Hui Yan, Yao Liu ... Daiwen Chen