Immunology and Inflammation

Immunology and Inflammation

eLife reviews research spanning allergy, immunity and immunoregulation, inflammation and T-cell receptor signalling. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Immunology and Inflammation

    Selective loss of CD107a TIGIT+ memory HIV-1-specific CD8+ T cells in PLWH over a decade of ART

    Oscar Blanch-Lombarte, Dan Ouchi ... Julia G Prado
    PLWH over a decade of ART showed a significant reshaping of the function and expression of inhibitory receptors across the CD8+ T cell landscape, ultimately leading to a decrease of CD107a TIGIT HIV-1-specific CD8+ T cells recovered by TIGIT blockade.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Epigenetic signature of human immune aging in the GESTALT study

    Roshni Roy, Pei-Lun Kuo ... Luigi Ferrucci
    Identification of human DNA sites differentially methylated with aging across six different primary immune cells suggests that the sensing of hypoxia drives the epigenetic clock.
    1. Immunology and Inflammation
    2. Neuroscience

    Molecular consequences of peripheral Influenza A infection on cell populations in the murine hypothalamus

    René Lemcke, Christine Egebjerg ... Birgitte R Kornum
    Identification of transcriptional changes in the hypothalamus during Influenza A virus infection enhances our understanding of mechanisms underlying long-lasting neurological disturbances, potentially informing future therapeutic interventions and improving patient outcomes.
    1. Immunology and Inflammation

    SPOP targets the immune transcription factor IRF1 for proteasomal degradation

    Irene Schwartz, Milica Vunjak ... Gijs A Versteeg
    SPOP-dependent degradation of interferon regulatory factor 1 curtails cell-intrinsic innate immunity, thereby contributing to immune resolution.
    1. Immunology and Inflammation

    Differences in the inflammatory proteome of East African and Western European adults and associations with environmental and dietary factors

    Godfrey S Temba, Nadira Vadaq ... Quirijn de Mast
    Comparing the inflammatory proteome of healthy Tanzanian and Dutch adults highlights a pro-inflammatory phenotype and metabolic differences in Tanzanians, with the potential role of food-derived metabolites in driving inflammation.

Senior editors

  1. Miles P Davenport
    University of New South Wales, Australia
  2. Betty Diamond
    The Feinstein Institute for Medical Research, United States
  3. Wendy S Garrett
    Wendy S Garrett
    Harvard T.H. Chan School of Public Health, United States
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