Jonathan CY Tang, Eugene Drokhlyansky ... Constance L Cepko
A straightforward, rapid and generalizable strategy uses modified nanobodies to convert intracellular protein detection into desired biological activities in cells and animals.
Benjamin Roland, Rebecca Jordan ... Alexander Fleischmann
Inhibitory circuits in the olfactory bulb can amplify or suppress sensory inputs over a wide range of intensities to generate robust mitral cell output.
Activation of the integrated stress response by stalled translation elongation complexes attenuates neurodegeneration, and demonstrates a protective link between a decrease in the rate of translation initiation and defects in translation elongation.
A learning-induced, motor-related, projection-specific signal from S1 to S2 accompanies reward-based-learning of a goal-directed sensorimotor transformation of whisker sensation into licking motor output.
Amyloid precursor protein expression and accumulation of its intracellular fragment are required for exuberant neurite outgrowth associated with pathological presenilin 1 loss-of-function mutations before the emergence of amyloid burden in mice.
Daniel L Felch, Arseny S Khakhalin, Carlos D Aizenman
During development, the Xenopus brain improves its ability to discern specific time intervals between sensory inputs of different modalities via the maturation of inhibitory circuits.
