Gaining genetic control over neural modules that drive the grooming of each Drosophila body part reveals how mechanisms for selecting among competing behavioral choices are used to generate sequences of actions.
3-10 weeks old adult-born granule cells provide two temporally overlapping but functionally distinct neuronal cell populations by being sensitive to distinct aspects of their inputs.
Neuroimaging provides novel insights into how the motor system represents sequences of actions by automatically separating their spatial and temporal features for flexible skill production.
Shawn McClelland, Gary P Brennan ... Tallie Z Baram
Uncovering the mechanisms by which the transcription factor NRSF contributes to the development of epilepsy reveals that the regulation of gene expression by transcription factors in the brain is more finely-tuned than previously thought.
Xueying Wang, John A Hayes ... Christopher A Del Negro
Laser-ablating neurons of a single genetic class reveals that Dbx1-derived interneurons comprise core respiratory rhythmogenic and premotor circuits and provides quantitative cellular parameters that govern network functionality
Diasynou Fioravante, YunXiang Chu ... Wade G Regehr
Genetic and electrophysiology experiments provide the first direct evidence that protein kinase C is a calcium-sensing protein in post-tetanic potentiation, a form of synaptic plasticity that supports short-term memory.
Conditional knockout of the small GTPase Cdc42 in excitatory neurons of the mouse forebrain leads to impaired long-term synaptic plasticity and impaired retrieval of remote memory.
