Highlights

  • Context-dependent behavior

    A region of the brain called the retrosplenial cortex has an important role in integrating contextual information and sensory stimuli in mice.

    Pol Bech, Robin F Dard ... Carl CH Petersen
    Reviewed Preprint Updated
  • Seeing movement

    Inhibitory feedback from GABAergic interneurons C2 and C3 is tied to neural computation of moving visual stimuli in Drosophila.

    Miriam Henning, Madhura D Ketkar ... Marion Silies
    Research Article
  • Testing the blood-brain barrier

    pdgfrb knockout zebrafish, which lack mural cells in their neurovasculature, retain restrictive permeability of the blood-brain barrier during developmental stages.

    Oguzhan F Baltaci, Andrea Usseglio Gaudi ... Benjamin M Hogan
    Research Article
  • Publish-review-curate at eLife

    eLife is rethinking how research is reviewed and published.

    Timothy E Behrens, Yamini Dalal, Diane M Harper
    Editorial
  • Science under threat

    How should the scientific community respond to ideological attacks on science?

    Humberto J Debat
    Feature Article
  • How to respond to peer reviewers

    Responding to peer reviews is a crucial part of publishing, but early-career researchers are rarely taught about it.

    Eric Kalkhoven, Manon Kluijtmans
    Feature Article

Latest research

    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Cell size modulates ferroptosis susceptibility

    Evgeny Zatulovskiy, Magdalena B Murray ... Jan M Skotheim
    Cellular sensitivity to cell death stimuli depends on cell-size-dependent proteome changes - specifically, cell size can modulate ferroptosis susceptibility through changes in glutathione biosynthetic enzymes, ferritin, and cathepsin B concentrations.
    1. Neuroscience

    Altered cognitive processes shape tactile perception in autism

    Ourania Semelidou, Mathilde Tortochot-Megne Fotso ... Andreas A Frick
    Altered tactile decision-making in autism reflects context-dependent weighting of sensory inputs and diminished integration of sensory history, enhancing low-salience discrimination while reducing category-based perceptual facilitation.
    1. Developmental Biology
    2. Genetics and Genomics

    PIK3CA-related overgrowth spectrum (PROS) zebrafish models reveal pan-lineage developmental dysregulation

    Hannah Brunsdon, Nuoya Wang ... E Elizabeth Patton
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    • Convincing
    1. Microbiology and Infectious Disease

    Niche exclusion of a lung pathogen in mice with designed probiotic communities

    Kelsey E Hern, Ashlee M Phillips ... Adam P Arkin
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Pupil size reveals the perceptual quality and effortless nature of synesthesia

    Christoph Strauch, Casper Leenaars, Romke Rouw
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
    1. Cancer Biology

    JAK-STAT Pathway Heterogeneity Governs Immunotherapy Response in Breast Cancer

    Jianbo Zhou, Heng Zhang ... Fu Peng
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Epidemiology and Global Health

    Understanding Pain in Polycystic Ovary Syndrome: Health Risks and Treatment Effectiveness

    Tess Cherlin, Stephanie Mohammed ... Shefali S Verma
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Compelling
    1. Ecology

    Beyond Acoustic Cues: Olfactory-Mediated Avoidance of Bats by Crickets

    Yannan Li, Wenhao Zhang ... Aiqing Lin
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Biochemistry and Chemical Biology

    Cytoplasmic circular dsDNA is a key constituent of stress granules

    Natalia A Demeshkina, Adrian R Ferré-D’Amaré
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Microbiology and Infectious Disease

    A dual role for PGLYRP1 in host defense and immune regulation during B. pertussis infection

    David M Rickert, Sasha Cardozo ... Ciaran Skerry
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid