Highlights

  • Eed and craniofacial development

    Eed, a subunit of the enzyme PRC2, controls important processes in craniofacial development after induction of the neural crest.

    Tim Casey-Clyde, S John Liu ... David R Raleigh
    Research Article

  • The power of pyruvate

    The metabolic fate of a nutrient called pyruvate determines how big cells become.

    Ashish G Toshniwal, Geanette Lam ... Jared Rutter
    Research Article

  • Microglia on the move

    Microglia adopt fundamentally different strategies for surveilling the health of neurons during chronic neurodegeneration.

    Sunitha Subhramanian, Olga Bocharova ... Ilia V Baskakov
    Reviewed Preprint Updated

  • Phosphate buffering

    Lysosome-related vacuoles control the metabolism of inorganic polyphosphates to stabilize the concentration of phosphate in the cytosol.

    Samuel Bru, Lydie Michaillat Mayer ... Andreas Mayer
    Research Article

  • Equity, diversity and inclusion

    eLife has published its 10th report on its work to address inequities in research and publishing.

    Inside eLife

  • The SAFE Labs Handbook

    New handbook could help group leaders to improve research culture in their labs.

    Erika Donà, James M Gahan ... Philip Coen
    Feature Article
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Neuroscience

    Maximized field-of-view deep-brain calcium imaging through gradient-index lenses

    Chenmao Wang, Zongyue Cheng ... Meng Cui
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Immunology and Inflammation

    Thymic self-recognition-mediated TCR signal strength modulates antigen- specific CD8+ T cell pathogenicity in non-obese diabetic mice

    Chia-Lo Ho, Li-Tzu Yeh ... Huey-Kang Sytwu
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Developmental Biology
    2. Neuroscience

    Voltage imaging reveals the emergence of population activity in the spinal cord

    Asuka Shiraishi, Ayane Hayashi ... Sachiko Tsuda
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Ecology

    Exogenous myristate fuels the growth of symbiotic arbuscular mycorrhizal fungi but disrupts their carbon-phosphorus exchange with host plants

    Hanwen Chen, Tian Xiong ... Yutao Wang
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Non-decision time-informed collapsing threshold diffusion model: A joint modeling framework with identifiable time-dependent parameters

    Amir Hosein Hadian Rasanan, Lukas Schumacher ... Jörg Rieskamp
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    Brain Perfusion Imaging of a Large Population: Arterial Spin Labelling MRI in UK Biobank

    Thomas W Okell, Xinyi Xu ... Michael A Chappell
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Microbiology and Infectious Disease

    Applying 3D correlative structured illumination microscopy and X-ray tomography to characterise herpes simplex virus-1 morphogenesis

    Kamal L Nahas, Viv Connor ... Colin M Crump
    Deletion of specific herpes simplex virus proteins prevents the progression of virus assembly at discrete stages, allowing detailed 3D imaging of rare events in the morphogenesis of virus particles.
    1. Biochemistry and Chemical Biology

    A green lifetime biosensor for calcium that remains bright over its full dynamic range

    Franka H van der Linden, Stephen C Thornquist ... Joachim Goedhart
    Directed evolution was used to engineer a green fluorescent biosensor for quantitative calcium imaging that remains fluorescent, yet shows a large change in lifetime in cells.
    1. Evolutionary Biology
    2. Genetics and Genomics

    G-protein-coupled receptor diversity and evolution in the closest living relatives of metazoa

    Alain Garcia De Las Bayonas, Nicole King
    Up-to-date computational pipeline characterizes G-protein-coupled receptor (GPCR) repertoires in the closest relatives of metazoans, providing a framework to investigate the evolutionary origins and ancestral functions of key metazoan signaling pathways.
    1. Immunology and Inflammation

    A co-evolutionary perspective on humans and Mycobacterium tuberculosis in the era of systems biology

    Michaela Reichmann, Liku B Tezera ... Paul Elkington
    Revised
    Reviewed Preprint v2
    Updated
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Magazine

    1. Cancer Biology

    Breast Cancer: Slowing the growth of drug-resistant tumors

    Yingyi Zhang, Qianying Lu
    1. Neuroscience

    Experience-Dependent Plasticity: The little brain supervises learning in the big brain

    Martha Garcia, Mark Wagner
    1. Microbiology and Infectious Disease

    Tuberculosis: A surprising new hiding place for a dangerous pathogen

    Sheetal Gandotra, Yogendra Singh
  4. Blurry photo of a flag, fish and a bird in the water

    Episode 101: December 2025

    1. Neuroscience

    Neuronal Activity: Keeping track of moving targets

    Renata Batista-Brito, Geoffrey Terral

  6. Research Culture: The SAFE Labs Handbook as a tool for improving lab culture

    Erika Donà, James M Gahan ... Philip Coen
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Metabolism: How one nutrient controls cell size

    Angela Montero, Lydia WS Finley
  8. See more Magazine articles

Categories

  1. Biochemistry and Chemical Biology
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  3. Cell Biology
  4. Chromosomes and Gene Expression
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  9. Evolutionary Biology
  10. Genetics and Genomics
  11. Immunology and Inflammation
  12. Medicine
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