Highlights

  • Hypoxia to healthspan

    Genetic tools highlight potential signalling components underlying hypoxia-induced longevity in C. elegans.

    Elizabeth S Kitto, Shijiao Huang ... Scott F Leiser
    Reviewed Preprint Updated

  • Symbionts shape pest traits

    Novel endosymbiotic bacteria have contrasting effects on the performance and dispersal of Russian wheat aphids and on the severity of damage caused to cereal host plants.

    Xinyue Gu, Alex Gill ... Ary A Hoffmann
    Reviewed Preprint Updated

  • Neurosecretory connections

    Connectomic and transcriptomic analyses reveal the anatomical and functional organisation of neurosecretion in the Drosophila brain.

    Theresa H McKim, Jayati Gera ... Meet Zandawala
    Reviewed Preprint Updated

  • Mapping regulatory DNA

    Cis-regulatory elements in the large genome of Parhyale hawaiensis can be identified by integrating chromatin accessibility and sequence conservation data.

    Gillian Forbes, Emilia Skafida ... Mathilde Paris
    Research Article

  • AI in research communication

    eLife has partnered on a number of projects harnessing AI for improving human and machine reader engagement with research.

    Inside eLife

  • Explore our new collection

    Delve into leading research on Lifestyle, Environment and Epigenetic Inheritance.

    Collection
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Computational and Systems Biology

    Role of desolvation on biomolecular liquid–liquid phase separation

    Kai Zhang, Zhiyu Peng ... Wei Wang
    A desolvation-aware coarse-grained framework enables efficient and physically realistic modeling of biomolecular phase separation by capturing water-mediated effects on phase behavior, dense-phase packing, conformational reorganization, and dynamics.
    1. Microbiology and Infectious Disease

    The structural context of mutations in proteins predicts their effect on antibiotic resistance

    Anna G Green, Mahbuba Tasmin ... Maha Reda Farhat
    Spatial clustering of mutations in Mycobacterium tuberculosis proteins finds proteins that are involved in antibiotic resistance, and predicts which mutations cause resistance.
    1. Genetics and Genomics
    2. Neuroscience

    Starvation transforms signal encoding in C. elegans thermoresponsive neurons and suppresses heat avoidance via bidirectional glutamatergic and peptidergic signaling

    Saurabh Thapliyal, Parvathi Sushama Gopinath, Dominique A Glauser
    Nutritional state dynamically reshapes sensory processing to prioritize behavioral responses, revealing the plastic coupling of sensation, internal state, and behavior.
    1. Neuroscience

    Effects of nicotine compared to placebo gum on sensitivity to pain and mediating effects of peak alpha frequency

    Samantha K Millard, Alan KI Chiang ... David A Seminowicz
    Revised
    Reviewed Preprint v3
    Updated
    • Useful
    • Solid
    • Incomplete
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    RelB proximity proteomics and CRISPR screening define chromatin regulators of noncanonical NF-κB control of HIV latency and reactivation

    Cameron R Bussey-Sutton, Carley N Gray ... Brian D Strahl
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Neuroscience

    Deep anatomical and ultrastructural classification of neurons in the zebrafish olfactory bulb

    Nila R Mönig, Michał Januszewski ... Rainer W Friedrich
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    Evidence for flexible regulation of movement and decision vigor in a reward-oriented task

    Adrien Conessa, Arnaud Boutin, Bastien Berret
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Neuroscience

    Small circuit principles for learning in large worlds

    Dhruva V Raman, Christopher R Dunne ... Timothy O’Leary
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Biochemistry and Chemical Biology

    Cell cycle-coupled CK1δ turnover, autoinhibition, and activity

    Fidel E Serrano, Bianca Ruppert ... Michael Brunner
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Neuroscience

    Two Interacting Neural Processes Support Speech Planning during Naturalistic Conversation

    Hiroyoshi Yamasaki, Philippe Blache, Daniele Schön
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
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Magazine

    1. Genetics and Genomics
    2. Developmental Biology
    grid of multicoloured bar graphs with vertical shaded areas in red and green highlighting specific columns

    Lifestyle, Environment and Epigenetic Inheritance: A Collection of Articles

    Edited by Wei Yan

  2. Research Culture: From East to West – an early-career researcher’s voyage across continents

    Samuel C Eziuzor
  3. Close-up of an iris

    Episode 105: September 2026

    1. Cell Biology
    2. Computational and Systems Biology

    Philosophy of Biology: The power of theory in the life sciences

    Jacob L Fine, Finn Creeggan ... Adam MR Groh
    1. Genetics and Genomics

    Environmental Learning: How experience shapes individuality

    Bassem A Hassan

  6. Point of View: Scientific writing is not a murder mystery

    Charlotte A Dodson
    1. Neuroscience

    Visual Categorization: How monkeys carve up the visual world

    Binxu Wang
  8. See more Magazine articles

Categories

  1. Biochemistry and Chemical Biology
  2. Cancer Biology
  3. Cell Biology
  4. Chromosomes and Gene Expression
  5. Computational and Systems Biology
  6. Developmental Biology
  7. Ecology
  8. Epidemiology and Global Health
  9. Evolutionary Biology
  10. Genetics and Genomics
  11. Immunology and Inflammation
  12. Medicine
  13. Microbiology and Infectious Disease
  14. Neuroscience
  15. Physics of Living Systems
  16. Physiology
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  18. Stem Cells and Regenerative Medicine
  19. Structural Biology and Molecular Biophysics
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