Highlights

  • Eed and craniofacial development

    Eed, a subunit of the enzyme PRC2, controls important processes in craniofacial development after induction of the neural crest.

    Tim Casey-Clyde, S John Liu ... David R Raleigh
    Research Article

  • The power of pyruvate

    The metabolic fate of a nutrient called pyruvate determines how big cells become.

    Ashish G Toshniwal, Geanette Lam ... Jared Rutter
    Research Article

  • Microglia on the move

    Microglia adopt fundamentally different strategies for surveilling the health of neurons during chronic neurodegeneration.

    Sunitha Subhramanian, Olga Bocharova ... Ilia V Baskakov
    Reviewed Preprint Updated

  • Phosphate buffering

    Lysosome-related vacuoles control the metabolism of inorganic polyphosphates to stabilize the concentration of phosphate in the cytosol.

    Samuel Bru, Lydie Michaillat Mayer ... Andreas Mayer
    Research Article

  • Equity, diversity and inclusion

    eLife has published its 10th report on its work to address inequities in research and publishing.

    Inside eLife

  • The SAFE Labs Handbook

    New handbook could help group leaders to improve research culture in their labs.

    Erika Donà, James M Gahan ... Philip Coen
    Feature Article
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Developmental Biology

    Single-Cell Characterization of Anterior Segment Development: Cell Types, Pathways, and Signals Driving Formation of the Trabecular Meshwork and Schlemm’s Canal

    Revathi Balasubramanian, Nicholas Tolman ... Simon WM John
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Chromosomes and Gene Expression

    ATAD2 mediates chromatin-bound histone chaperone turnover

    Ariadni Liakopoulou, Fayçal Boussouar ... Saadi Khochbin
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Developmental Biology

    The Drosophila EGF domain protein Uninflatable sets the switch between wrapping glia growth and axon wrapping instructed by Notch

    Marie Baldenius, Steffen Kautzmann ... Christian Klämbt
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Immunology and Inflammation
    2. Evolutionary Biology

    Separating selection from mutation in antibody language models

    Frederick A Matsen, Will Dumm ... Hugh K Haddox
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Developmental Biology

    Rtf1-dependent transcriptional pausing regulates cardiogenesis

    Adam D Langenbacher, Fei Lu ... Jau-Nian Chen
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Structural Biology and Molecular Biophysics
    2. Medicine

    Direct MRI of Collagen

    Jason Daniel van Schoor, Markus Weiger ... Klaas Paul Pruessmann
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Chromosomes and Gene Expression

    Fragile nucleosomes are essential for RNA Polymerase II to transcribe in eukaryotes

    Lingbo Li, Samuel Hunter ... Gongyi Zhang
    Not revised
    Reviewed Preprint v1
    • Important
    • Inadequate
    1. Neuroscience

    PKD2L1 channels segregated to the apical compartment are the exclusive dual-mode pH sensor in cerebrospinal fluid-contacting neurons

    Magdalena Vitar, Daniel Prieto ... Federico F Trigo
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Heterochronic transcription factor expression drives cone-dominant retina development in 13-lined ground squirrels

    Kurt Weir, Pin Lyu ... Seth Blackshaw
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Neuroscience

    Integrating bulk and single cell RNA-seq refines transcriptomic profiles of individual C. elegans neurons

    Alec Barrett, Erdem Varol ... Marc Hammarlund
    Revised
    Reviewed Preprint v2
    Updated
    • Important
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Magazine

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    1. Cancer Biology

    Breast Cancer: Slowing the growth of drug-resistant tumors

    Yingyi Zhang, Qianying Lu
    1. Neuroscience

    Experience-Dependent Plasticity: The little brain supervises learning in the big brain

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    1. Microbiology and Infectious Disease

    Tuberculosis: A surprising new hiding place for a dangerous pathogen

    Sheetal Gandotra, Yogendra Singh
  5. Blurry photo of a flag, fish and a bird in the water

    Episode 101: December 2025

    1. Neuroscience

    Neuronal Activity: Keeping track of moving targets

    Renata Batista-Brito, Geoffrey Terral

  7. Research Culture: The SAFE Labs Handbook as a tool for improving lab culture

    Erika Donà, James M Gahan ... Philip Coen
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Categories

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