Highlights

  • Seeing movement

    Inhibitory feedback from GABAergic interneurons C2 and C3 is tied to neural computation of moving visual stimuli in Drosophila.

    Miriam Henning, Madhura D Ketkar ... Marion Silies
    Research Article
  • Testing the blood-brain barrier

    pdgfrb knockout zebrafish, which lack mural cells in their neurovasculature, retain restrictive permeability of the blood-brain barrier during developmental stages.

    Oguzhan F Baltaci, Andrea Usseglio Gaudi ... Benjamin M Hogan
    Research Article
  • Making of the microenvironment

    Single-cell sequencing and multi-omics approaches reveal the influence of BRCA1/2 mutations on the tumor microenvironment in lung adenocarcinoma.

    Gaoming Liao, Xinbin Yang ... Gang Xu
    Research Article
  • Publish-review-curate at eLife

    eLife is rethinking how research is reviewed and published.

    Timothy E Behrens, Yamini Dalal, Diane M Harper
    Editorial
  • Science under threat

    How should the scientific community respond to ideological attacks on science?

    Humberto J Debat
    Feature Article
  • How to respond to peer reviewers

    Responding to peer reviews is a crucial part of publishing, but early-career researchers are rarely taught about it.

    Eric Kalkhoven, Manon Kluijtmans
    Feature Article

Latest research

    1. Neuroscience

    Head before heart: cognitive empathy emerges before affective empathy in the developing brain

    Chiara Bulgarelli, Paola Pinti ... Emily J Jones
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Microbiology and Infectious Disease

    Virus specific impacts on honey bee flight performance are mediated by the octopamine pathway

    Naomi G Kaku, Michelle L Flenniken
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Genetics and Genomics

    The cistrome response to hypoxia in human umbilical vein endothelial cells

    Ayush Singh, Viktor Pastukh ... Hank W Bass
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Synaptotagmin isoforms differentially regulate glutamate and GABA release in the lateral habenula

    Dustin N White, J Keenan Kushner ... Michael HB Stowell
    Not revised
    Reviewed Preprint v1
    • Useful
    • Inadequate
    1. Evolutionary Biology

    Species biology and demographic history determine species vulnerability to climate change in tropical island endemic birds

    Ratnesh Karjee, Vikram Iyer ... Balaji Chattopadhyay
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Inadequate
    1. Medicine
    2. Neuroscience

    Functional Muscle Networks as Biomarkers of Post-Stroke Motor Impairment and Therapeutic Responsiveness

    David O’Reilly, Giorgia Pregnolato ... Giacomo Severini
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Solid
    1. Neuroscience

    Visual Working Memory Guides Attention Rhythmically

    Jiachen Lu, Yaochun Cai, Xilin Zhang
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Fragile polyQ assemblies cause Golgipathy in Huntington’s disease

    Lixiang Ma, Xinyu Chen ... Hexige Saiyin
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Immunology and Inflammation

    Simplifying principles that underlie the highly complex peptide motif of the promiscuous chicken class I molecule, BF2*21:01

    Michael Harrison, Paul E Chappell ... Jim Kaufman
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Immunology and Inflammation
    2. Neuroscience

    Cribriform Plate Microenvironment Assembles a Suppressive Myeloid Network during EAE-induced Neuroinflammation

    Collin Laaker, Martin Hsu ... Zsuzsanna Fabry
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing