Highlights

  • Closing the neural tube

    High-throughput arrayed CRISPR interference screening of organoid models gives insight into genetic regulators of neural tube closure in humans.

    Roya E Huang, Giridhar M Anand ... Sharad Ramanathan
    Research Article

  • Hippocampal memory

    Genetic evidence highlights the roles of atypical protein kinase C isoforms in hippocampal late-phase long-term potentiation and long-term memory.

    Panayiotis Tsokas, Changchi Hsieh ... Todd Charlton Sacktor
    Research Advance

  • Signals for retinal development

    Synchronous waves of activity in the developing retina of postnatal mice potentially involve purinergic signalling triggered by apoptotic retinal ganglia.

    Michael A Savage, Cori Bertram ... Evelyne Sernagor
    Reviewed Preprint Updated

  • Publish-review-curate at eLife

    eLife is rethinking how research is reviewed and published.

    Timothy E Behrens, Yamini Dalal, Diane M Harper
    Editorial

  • Insights into synaptic dysfunction

    LRRK2, a protein linked to Parkinson’s disease, interacts with an actin-binding protein, drebrin, to regulate synaptic function and has a role in BDNF-dependent synaptic modulation.

    Giulia Tombesi, Shiva Kompella ... Elisa Greggio
    Research Article

  • Science under threat

    How should the scientific community respond to ideological attacks on science?

    Humberto J Debat
    Feature Article
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Structural Biology and Molecular Biophysics

    Characterization of an early-diverging KCNE potassium-channel auxiliary subunit in the jawless vertebrate lamprey

    Go Kasuya, Kaei Ryu ... Koichi Nakajo
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cell Biology
    2. Developmental Biology

    Bruce suppresses autophagy-regulated caspase activity and wing tissue growth in Drosophila

    Natsuki Shinoda, Yutaro Hama ... Masayuki Miura
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Structural Biology and Molecular Biophysics

    Molecular basis of mitogen-activated protein kinase ERK2 activation by its upstream kinase MEK1

    Jill von Velsen, Pauline Juyoux ... Matthew W Bowler
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Adaptive behavior is guided by integrated representations of controlled and non-controlled information

    Bingfang Huang, Harrison Ritz, Jiefeng Jiang
    Revised
    Reviewed Preprint v3
    Updated
    • Useful
    • Incomplete
    1. Neuroscience

    Characterising semantic prioritisation in visual working memory

    Casper Kerrén, Carlos González-García, Juan Linde-Domingo
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience

    Accumulation of neural state transitions in dorsomedial striatum predicts patch foraging decisions

    Elissa Sutlief, Shichen Zhang ... Marshall G Hussain Shuler
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Explainable machine learning-assisted exploration of chromatin dynamics reveals chromosome-specific response to serum starvation

    Taras Redchuk, Antti P Pennanen ... Maria K Vartiainen
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Medicine

    Evaluating the applicability of replication success metrics in animal-to-human translation: A simulation study

    Carolyne Jie Huang, Samuel Pawel ... Rachel Heyard
    A simulation study shows that metrics suggested to assess replication studies are useful in the translation context, but researchers need to clarify their translation goals a priori.
    1. Neuroscience

    Functional specialization of mPFC-BLA and mPFC-NAc pathways in affective state representation

    Chien-Hsien Lai, Gyeongah Park ... Jianyang Du
    Separate prefrontal output channels preferentially track anxiety, exploration, and social preference, revealing how emotional context is organized into adaptive behavior.
    1. Neuroscience

    Mood computational mechanisms underlying increased risk behavior in adolescent suicidal patients

    Zhihao Wang, Tian Nan ... Bastien Blain
    Adolescent suicidality is linked to riskier choices through stronger attraction to high-reward gambles and blunted mood responses to safe rewards.
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Magazine

    1. Epidemiology and Global Health

    Malaria Prevention: Using mathematical models to optimise mosquito net distribution

    Carlos A Prete Jr
    1. Plant Biology

    Mixotrophy: An updated view of glucose pathways in cyanobacteria

    José Manuel García-Fernández
  3. Mountain gorilla

    Episode 104: July 2026

    1. Cell Biology
    2. Developmental Biology

    Organ Development: Following your heart as it takes shape

    Alexandra Trouilloud, Nicole C Dubois
    1. Cancer Biology

    Tumor Biology: The two faces of JAK-STAT

    Qianying Lu, Yingyi Zhang
    1. Neuroscience

    Brain Mapping: Understanding the cellular architecture of Huntington’s disease

    Dorian Pustina
    1. Physics of Living Systems

    Vector Biology: The exquisite mechanics of a tsetse bite

    Katelyn Fealy, Álvaro Acosta-Serrano
  8. See more Magazine articles

Categories

  1. Biochemistry and Chemical Biology
  2. Cancer Biology
  3. Cell Biology
  4. Chromosomes and Gene Expression
  5. Computational and Systems Biology
  6. Developmental Biology
  7. Ecology
  8. Epidemiology and Global Health
  9. Evolutionary Biology
  10. Genetics and Genomics
  11. Immunology and Inflammation
  12. Medicine
  13. Microbiology and Infectious Disease
  14. Neuroscience
  15. Physics of Living Systems
  16. Physiology
  17. Plant Biology
  18. Stem Cells and Regenerative Medicine
  19. Structural Biology and Molecular Biophysics
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