Highlights

  • Drug-resistant sleeping sickness

    Mutations in a water channel called TbAQP2 make the parasite that causes sleeping sickness resistant to drugs. Image: Jessica Eggers (CC BY 4.0).

    Modestas Matusevicius, Robin A Corey ... Simone N Weyand
    Reviewed Preprint Updated

  • Modelling archaeal membranes

    Archaea use single-headed and double-headed lipids to construct cell membranes that are both flexible and capable of withstanding extreme environments.

    Miguel Amaral, Felix Frey ... Anđela Šarić
    Research Article

  • ITP signaling and homeostasis

    The ion transport peptide (ITP) signaling system relies on a guanylate cyclase receptor to maintain homeostasis in Drosophila.

    Jayati Gera, Marishia Agard ... Meet Zandawala
    Research Article

  • How we understand each other

    eLife author Joe Barnby answers questions about a study that explored how humans navigate social interactions.

    Inside eLife

  • Focus Issue: Trained Immunity

    The articles in this focus issue discuss progress towards a better understanding of memory in the innate immune system, and efforts to develop new vaccines and therapeutics based on “trained immunity”.

    Collection

  • No change for astroctyes

    Genetically removing the RNA-binding protein PTBP1 from astrocytes does not convert them into neurons, contrary to previous claims.

    Min Zhang, Naoto Kubota ... Sika Zheng
    Reviewed Preprint Updated
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Biochemistry and Chemical Biology

    Aggregation-Dependent Epitope Sequence and Modification Fingerprints of Anti-Aβ Antibodies

    Ivan Talucci, Timon Leske ... Hans Michael Maric
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Medicine

    Are peer reviewers influenced by their work being cited?

    Adrian Barnett
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Chromosomes and Gene Expression

    The chromatin remodeller CHD4 regulates transcription factor binding to both prevent activation of silent enhancers and maintain active regulatory elements

    Andria Koulle, Oluwaseun Ogundele ... Brian Hendrich
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Neuroscience
    2. Computational and Systems Biology

    Reconstructing Voice Identity from Noninvasive Auditory Cortex Recordings

    Charly Lamothe, Etienne Thoret ... Pascal Belin
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Microbiology and Infectious Disease

    Functional genomics reveals strain-specific genetic requirements conferring hypoxic growth in Mycobacterium intracellulare

    Yoshitaka Tateishi, Yuriko Ozeki ... Sohkichi Matsumoto
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
    1. Neuroscience

    Synaptic density and relative connectivity conservation maintain circuit stability across development

    Ingo Fritz, Feiyu Wang ... André Ferreira Castro
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cell Biology
    2. Neuroscience

    Endosome-associated Rab GTPases control distinct aspects of neural circuit assembly

    Katherine X Dong, Hui Ji ... Colleen N McLaughlin
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Spatially heterogeneous inhibition projects sequential activity onto unique neural subspaces

    Andrew B Lehr, Arvind Kumar, Christian Tetzlaff
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    From cognition to compensation: Neurocomputational mechanisms of guilt-driven and shame-driven altruistic behavior

    Ruida Zhu, Huanqing Wang ... Chao Liu
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Microbiology and Infectious Disease
    2. Epidemiology and Global Health

    Timely vaccine strain selection and genomic surveillance improves evolutionary forecast accuracy of seasonal influenza A/H3N2

    John Huddleston, Trevor Bedford
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
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Magazine

    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Metabolism: How one nutrient controls cell size

    Angela Montero, Lydia WS Finley
    1. Genetics and Genomics

    Transgenerational Epigenetic Inheritance: Twists and turns in the story of learned avoidance

    Lesley T MacNeil
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease
    3. Medicine

    Focus Issue: Trained Immunity

    Edited by Satyajit Rath et al.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Focus Issue: Evolving our understanding of trained immunity

    Eva Kaufmann, Yahya Sohrabi ... Jos WM van der Meer
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Bacteriology: How Shigella tackles host defences

    Yizhou Huang, Teresa LM Thurston
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Chromosomes: Exploring a crossroads in the aging process

    Kiyan Shabestary, Daniel E Gottschling
    1. Neuroscience

    Neuronal Migration: How hunger guides new brain cells to their destination

    Fang-Shin Nian, Laurent Nguyen
  8. See more Magazine articles

Categories

  1. Biochemistry and Chemical Biology
  2. Cancer Biology
  3. Cell Biology
  4. Chromosomes and Gene Expression
  5. Computational and Systems Biology
  6. Developmental Biology
  7. Ecology
  8. Epidemiology and Global Health
  9. Evolutionary Biology
  10. Genetics and Genomics
  11. Immunology and Inflammation
  12. Medicine
  13. Microbiology and Infectious Disease
  14. Neuroscience
  15. Physics of Living Systems
  16. Plant Biology
  17. Stem Cells and Regenerative Medicine
  18. Structural Biology and Molecular Biophysics
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