Highlights

  • Closing the neural tube

    High-throughput arrayed CRISPR interference screening of organoid models gives insight into genetic regulators of neural tube closure in humans.

    Roya E Huang, Giridhar M Anand ... Sharad Ramanathan
    Research Article
  • Mechanics of oncogenesis

    Integrative mechanobiological approaches provide insight into the biophysics of tissue-specific tumor growth.

    Amrapali Datta, Phanindra Dewan ... Medhavi Vishwakarma
    Research Article
  • Signals for retinal development

    Synchronous waves of activity in the developing retina of postnatal mice potentially involve purinergic signalling triggered by apoptotic retinal ganglia.

    Michael A Savage, Cori Bertram ... Evelyne Sernagor
    Reviewed Preprint Updated
  • Publish-review-curate at eLife

    eLife is rethinking how research is reviewed and published.

    Timothy E Behrens, Yamini Dalal, Diane M Harper
    Editorial
  • Hippocampal memory

    Genetic evidence highlights the roles of atypical protein kinase C isoforms in hippocampal late-phase long-term potentiation and long-term memory.

    Panayiotis Tsokas, Changchi Hsieh ... Todd Charlton Sacktor
    Research Advance
  • Science under threat

    How should the scientific community respond to ideological attacks on science?

    Humberto J Debat
    Feature Article

Latest research

    1. Neuroscience

    Closed-loop neurofeedback reshapes preparatory brain states to bias subsequent pain processing

    Yinhua Zhang, Shuang Qiu ... Weiwei Peng
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    A shared neural code for gender across faces, bodies, and objects in the human brain

    Wenjie Liu, Xiqian Lu ... Yi Jiang
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Physiology

    Reproductive experience promotes permanent body growth independently of growth hormone

    Gabriel O de Souza, Willian O dos Santos ... Jose Donato
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Essential role for plasma membrane glutamate transporters in stimulus intensity coding in auditory neurons

    Tenzin Ngodup, Laurence O Trussell
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Hierarchical Neural Circuit Theory of Normalization and Inter-areal Communication

    Asit Pal, Shivang Rawat ... Stefano Martiniani
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Neural computations in the foveal and peripheral visual fields during active search

    Jie Zhang, Xiaocang Zhu ... Huihui Zhou
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Neuroscience
    2. Computational and Systems Biology

    Individual differences drive social hierarchies in male mouse societies

    Jonathan R Reinwald, Sarah Ghanayem ... Wolfgang Kelsch
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Neuroscience

    Microsaccades track shifting but not necessarily maintaining covert visual-spatial attention

    Anna M van Harmelen, Freek van Ede
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Microbiology and Infectious Disease

    Bacteria detect neutrophils via a system that responds to hypochlorous acid and flow

    Ilona P Foik, Summer J Kasallis ... Albert Siryaporn
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing