Highlights

  • No change for astroctyes

    Genetically removing the RNA-binding protein PTBP1 from astrocytes does not convert them into neurons, contrary to previous claims.

    Min Zhang, Naoto Kubota ... Sika Zheng
    Research Article

  • Eed and craniofacial development

    Eed, a subunit of the enzyme PRC2, controls important processes in craniofacial development after induction of the neural crest.

    Tim Casey-Clyde, S John Liu ... David R Raleigh
    Research Article

  • Phosphate buffering

    Lysosome-related vacuoles control the metabolism of inorganic polyphosphates to stabilize the concentration of phosphate in the cytosol.

    Samuel Bru, Lydie Michaillat Mayer ... Andreas Mayer
    Research Article

  • How we understand each other

    eLife author Joe Barnby answers questions about a study that explored how humans navigate social interactions.

    Inside eLife

  • Focus Issue: Trained Immunity

    The articles in this focus issue discuss progress towards a better understanding of memory in the innate immune system, and efforts to develop new vaccines and therapeutics based on “trained immunity”.

    Collection

  • Equity, diversity and inclusion

    eLife has published its 10th report on its work to address inequities in research and publishing.

    Inside eLife
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Evolutionary Biology

    Integration of multi-level dental diversity links macro-evolutionary patterns to ecological strategies across sharks

    Roland Zimm, Vitória Tobias Santos, Nicolas Goudemand
    Shark dentition is a complex and hyper-diverse trait integrating multiple spatial levels, with mid-scale features being most crucial for functional adaptation, revealing evolutionary patterns that offer insights into distinct ecological strategies.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Role of ADMA-histones in dual-strand piRNA source loci recognition by Rhino

    Raku Saito, Hirotsugu Ishizu ... Mikiko C Siomi
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Cancer Biology

    Mitochondrial Protein Carboxyl-Terminal Alanine-Threonine Tailing Promotes Glioblastoma Tumor Growth by Regulating Mitochondrial Function

    Bei Zhang, Ting Cai ... Zhihao Wu
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
    1. Neuroscience

    Causal evidence for a domain-specific role of left superior frontal sulcus in human perceptual decision making

    Miguel Barretto García, Marcus Grueschow ... Christian C Ruff
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Cell Biology

    Adaptation of endothelial cells to microenvironment topographical cues through lysyl oxidase like-2-mediated basement membrane scaffolding

    Marion F Marchand, Noémie Brassard-Jollive ... Laurent Muller
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology

    Extracellular vesicle-mediated release of bis(monoacylglycerol)phosphate is regulated by LRRK2 and Glucocerebrosidase activity

    Elsa Meneses-Salas, Moisés Castellá ... Albert Lu
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Evolution of a fuzzy ribonucleoprotein complex in viral assembly

    Huaying Zhao, Tiansheng Li ... Peter Schuck
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Multiscale dynamical characterization of cortical brain states: from synchrony to asynchrony

    Maria V Sanchez-Vives, Arnau Manasanch ... Alain Destexhe
    Not revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Noncanonical amino acid incorporation enables minimally disruptive labeling of stress granule and TDP-43 proteinopathy

    Hao Chen, Haocheng Wang ... Jiou Wang
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience

    State-dependent brain responsiveness, from local circuits to the whole brain

    Alain Destexhe, Jennifer S Goldman ... Maria V Sanchez-Vives
    Not revised
    Reviewed Preprint v1
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Magazine

    1. Microbiology and Infectious Disease

    Tuberculosis: A surprising new hiding place for a dangerous pathogen

    Sheetal Gandotra, Yogendra Singh
  2. Blurry photo of a flag, fish and a bird in the water

    Episode 101: December 2025

    1. Neuroscience

    Neuronal Activity: Keeping track of moving targets

    Renata Batista-Brito, Geoffrey Terral

  4. Research Culture: The SAFE Labs Handbook as a tool for improving lab culture

    Erika Donà, James M Gahan ... Philip Coen
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Metabolism: How one nutrient controls cell size

    Angela Montero, Lydia WS Finley
    1. Genetics and Genomics

    Transgenerational Epigenetic Inheritance: Twists and turns in the story of learned avoidance

    Lesley T MacNeil
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease
    3. Medicine

    Focus Issue: Trained Immunity

    Edited by Satyajit Rath et al.
  8. See more Magazine articles

Categories

  1. Biochemistry and Chemical Biology
  2. Cancer Biology
  3. Cell Biology
  4. Chromosomes and Gene Expression
  5. Computational and Systems Biology
  6. Developmental Biology
  7. Ecology
  8. Epidemiology and Global Health
  9. Evolutionary Biology
  10. Genetics and Genomics
  11. Immunology and Inflammation
  12. Medicine
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  15. Physics of Living Systems
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  17. Stem Cells and Regenerative Medicine
  18. Structural Biology and Molecular Biophysics
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