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  4. Chromosomes and Gene Expression
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  10. Genetics and Genomics
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  14. Neuroscience
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  18. Structural Biology and Molecular Biophysics
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Highlights

  • Deep mutational scanning

    High-resolution approach has been used to assess the effect of more than 6000 protein-coding variants in a G protein-coupled receptor associated with obesity.

    Conor J Howard, Nathan S Abell ... Nathan B Lubock
    Reviewed Preprint Updated

  • eLife wins award for UX

    eLife wins user experience (UX) award from OpenAthens for its user-driven approach to the design of Reviewed Preprints.

    Press Pack

  • eLife Community Ambassadors

    Over 100 early-career researchers from around the world have joined scheme to create change across the global research community.

    Inside eLife

Latest research

    1. Neuroscience

    Minimal background noise enhances neural speech tracking: Evidence of stochastic resonance

    Björn Herrmann
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Evolutionary Biology

    Social and environmental predictors of gut microbiome age in wild baboons

    Mauna R Dasari, Kimberly E Roche ... Elizabeth A Archie
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Microbiology and Infectious Disease
    2. Ecology

    Effects of parental care on skin microbial community composition in poison frogs

    Marie-Therese Fischer, Katherine S Xue ... Lauren A O’Connell
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete
    1. Neuroscience

    MLCK/MLCP regulates mammalian axon regeneration and redistributes the growth cone F-actin

    Saijilafu, Wei-Hua Wang ... Yan-Xia Ma
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    1. Microbiology and Infectious Disease

    Amidase and lysozyme dual functions in TseP reveal a new family of chimeric effectors in the type VI secretion system

    Zeng-Hang Wang, Ying An ... Tao Dong
    Structural and functional analyses identify a new family of bifunctional cell-wall-targeting type VI secretion system (T6SS) effectors and a surface-charge-engineering strategy that expands T6SS activity against Gram-positive cells.
    1. Developmental Biology

    Single-nucleus multiomics reveals the gene regulatory networks underlying sex determination of murine primordial germ cells

    Adriana K Alexander, Karina F Rodriguez ... Humphrey HC Yao
    Single-cell multiomic analyses reveal known and new genes and pathways involved in the development of germ cells and provide a discovery platform for the scientific community.
    1. Neuroscience

    Dopamine increases protein synthesis in hippocampal neurons enabling dopamine-dependent LTP

    Tanja Fuchsberger, Imogen Stockwell ... Ole Paulsen
    The reward signal dopamine modulates synaptic plasticity by increasing protein synthesis, revealing a potential molecular mechanism for long-term memory storage.
    1. Developmental Biology

    The asymmetric expression of HSPA2 in blastomeres governs the first embryonic cell-fate decision

    Jiayin Gao, Jiawei Wang ... Keliang Wu
    HSPA2 as a critical early regulator of the first cell-fate decision in mammalian embryos.
    1. Neuroscience

    Aminergic and peptidergic modulation of insulin-producing cells in Drosophila

    Martina Held, Rituja S Bisen ... Jan M Ache
    The combination of receptor expression analysis, optogenetics, physiological approaches, and connectomics reveals how a heterogeneous population of insulin-producing cells in Drosophila integrates diverse modulatory inputs to adjust insulin release.
    1. Cell Biology
    2. Genetics and Genomics

    DNA replication in primary hepatocytes without the six-subunit ORC

    Róża K Przanowska, Yuechuan Chen ... Anindya Dutta
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
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Magazine

    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Cellular Energy Production: Mycofactocin and the mycobacterial electron transport chain

    Stephanie M Stuteley, Ghader Bashiri
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Transcription: The plusses and minuses of DNA torsion

    Steven Henikoff, David L Levens

  3. Episode 97: February 2025

    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Neurodegeneration: A role for RNA knots in Alzheimer’s disease

    Silvia Galli, Marco Di Antonio
    1. Developmental Biology

    Morphogenesis: Fluid transport comes to the fore

    Yufei Wu, Sean X Sun
    1. Developmental Biology
    2. Neuroscience

    Axon Guidance: Watching axons on the move

    Maria I Lazaro-Pena, Carlos A Diaz-Balzac
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Drug Discovery: How to exploit the recycling system of a cell

    Sasha L Evans, Bethany A Haynes ... Rivka L Isaacson
  8. See more Magazine articles