Highlights

  • Closing the neural tube

    High-throughput arrayed CRISPR interference screening of organoid models gives insight into genetic regulators of neural tube closure in humans.

    Roya E Huang, Giridhar M Anand ... Sharad Ramanathan
    Research Article

  • Hippocampal memory

    Genetic evidence highlights the roles of atypical protein kinase C isoforms in hippocampal late-phase long-term potentiation and long-term memory.

    Panayiotis Tsokas, Changchi Hsieh ... Todd Charlton Sacktor
    Research Advance

  • Insights into synaptic dysfunction

    LRRK2, a protein linked to Parkinson’s disease, interacts with an actin-binding protein, drebrin, to regulate synaptic function and has a role in BDNF-dependent synaptic modulation.

    Giulia Tombesi, Shiva Kompella ... Elisa Greggio
    Reviewed Preprint Updated

  • Publish-review-curate at eLife

    eLife is rethinking how research is reviewed and published.

    Timothy E Behrens, Yamini Dalal, Diane M Harper
    Editorial

  • Modulating hyperexcitability

    PRRT2, a transmembrane protein, helps to limit neuronal hyperexcitability by modulating slow inactivation of voltage-gated sodium channels.

    Bin Lu, Qi-Wu Xu ... Zhi-Qi Xiong
    Reviewed Preprint Updated

  • Science under threat

    How should the scientific community respond to ideological attacks on science?

    Humberto J Debat
    Feature Article
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Neuroscience

    Split-trial analysis reveals the information capacity of neural population codes

    Dylan Le, Xue-Xin Wei
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Rapid cortical reorganization tracks goal-directed sensorimotor learning in real time

    Anthony Renard, Georgios Foustoukos ... Carl CH Petersen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Neuroscience
    2. Computational and Systems Biology

    Structured stabilization in recurrent neural circuits through inhibitory synaptic plasticity

    Dylan Festa, Claudia Cusseddu, Julijana Gjorgjieva
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    Flexible brain state engagement predicts cognitive control transdiagnostically

    Jean Ye, Saloni Mehta ... Dustin Scheinost
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Demonstrating the ability of GABAergic cells in the zona incerta to modulate motivation

    Laura Korobkova, Brian G Dias
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Chromosomes and Gene Expression
    2. Physiology

    Gene dosage imbalance disrupts systemic metabolism in the Dp16 Down syndrome mouse model

    Fangluo Chen, Muzna Saqib ... G William Wong
    Gene dosage imbalance due to the triplication of human chromosome 21 gene orthologs impairs whole-body glucose and lipid metabolism by disrupting homeostatic processes across major metabolic tissues.
    1. Neuroscience

    Toothy: an interactive platform for dentate spike curation

    Kathleen N Esfahany, Amanda L Schott ... Jordan S Farrell
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Developmental Biology
    2. Neuroscience

    foxQ2 marks fast-acting brain interneurons including a subset of dopaminergic neurons innervating mushroom bodies and central complex in the beetle Tribolium castaneum

    Ying Pang, Bastian Klußmann-Fricke ... Gregor Bucher
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Epidemiology and Global Health

    Repurposed small molecule toxin inhibitors neutralise a diversity of venoms from the Neotropical viperid snake genus Bothrops

    Rachel H Clare, Adam Westhorpe ... Nicholas R Casewell
    Despite the variation in venom across the Bothrops snake genus, repurposed drugs demonstrated pan-species neutralisation in enzymatic, coagulation, and haemorrhage assays, highlighting their value as novel therapies for Neotropical snakebites.
    1. Cell Biology

    Decoupling AMPK from fatty acid synthesis allows maintenance of fitness late in life

    Hanane Hadj-Moussa, Megan Ulusan ... Jonathan Houseley
    Re-engineering a highly conserved metabolic pathway in yeast prevents age-related functional decline and proves that ageing is not inevitably linked to loss of fitness.
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Magazine

  1. Mountain gorilla

    Episode 104: July 2026

    1. Cell Biology
    2. Developmental Biology

    Organ Development: Following your heart as it takes shape

    Alexandra Trouilloud, Nicole C Dubois
    1. Cancer Biology

    Tumor Biology: The two faces of JAK-STAT

    Qianying Lu, Yingyi Zhang
    1. Neuroscience

    Brain Mapping: Understanding the cellular architecture of Huntington’s disease

    Dorian Pustina
    1. Physics of Living Systems

    Vector Biology: The exquisite mechanics of a tsetse bite

    Katelyn Fealy, Álvaro Acosta-Serrano
    1. Physics of Living Systems

    Actin Filaments: Building bundles by the numbers

    Christian Vanhille-Campos, Anđela Šarić
    1. Neuroscience

    Hippocampal Network: Stronger memories through smarter stimulation

    Justin Riddle
  8. See more Magazine articles

Categories

  1. Biochemistry and Chemical Biology
  2. Cancer Biology
  3. Cell Biology
  4. Chromosomes and Gene Expression
  5. Computational and Systems Biology
  6. Developmental Biology
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  8. Epidemiology and Global Health
  9. Evolutionary Biology
  10. Genetics and Genomics
  11. Immunology and Inflammation
  12. Medicine
  13. Microbiology and Infectious Disease
  14. Neuroscience
  15. Physics of Living Systems
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  19. Structural Biology and Molecular Biophysics
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