Highlights

  • Hypoxia to healthspan

    Genetic tools highlight potential signalling components underlying hypoxia-induced longevity in C. elegans.

    Elizabeth S Kitto, Shijiao Huang ... Scott F Leiser
    Reviewed Preprint Updated

  • Symbionts shape pest traits

    Novel endosymbiotic bacteria have contrasting effects on the performance and dispersal of Russian wheat aphids and on the severity of damage caused to cereal host plants.

    Xinyue Gu, Alex Gill ... Ary A Hoffmann
    Reviewed Preprint Updated

  • Neurosecretory connections

    Connectomic and transcriptomic analyses reveal the anatomical and functional organisation of neurosecretion in the Drosophila brain.

    Theresa H McKim, Jayati Gera ... Meet Zandawala
    Research Article

  • Mapping regulatory DNA

    Cis-regulatory elements in the large genome of Parhyale hawaiensis can be identified by integrating chromatin accessibility and sequence conservation data.

    Gillian Forbes, Emilia Skafida ... Mathilde Paris
    Research Article

  • AI in research communication

    eLife has partnered on a number of projects harnessing AI for improving human and machine reader engagement with research.

    Inside eLife

  • Explore our new collection

    Delve into leading research on Lifestyle, Environment and Epigenetic Inheritance.

    Collection
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Neuroscience
    2. Computational and Systems Biology

    A theory-guided model maps four recurrent modes of fear-goal arbitration across learning and relapse in rats

    Bin Yin, Jiaojiao Rao, XT (XiaoTian) Wang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Spatiotemporal Dissociation of Human Amygdala Response to Negative Affect

    Ke Bo, Martin A Lindquist ... Tor D Wager
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Phosphorylation and pocket-binding ligands rewire the coupled networks in multidomain protein condensate

    Yu Cao, Jinyu Chen, Xiakun Chu
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Developmental Biology

    Wnt/beta-catenin signaling regulates Vascular Endothelial Growth Factor (VEGF) receptors in central nervous system endothelial cells

    Yanshu Wang, Ningyu Zhu ... Jeremy Nathans
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Cell Biology

    Whole human organ clearing and multimodal mapping

    Héloïse Policet-Bétend, Tomàs Jordà-Siquier ... Christophe M Lamy
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Computational and Systems Biology

    Penumbria: Advanced 3D cell segmentation for biomedical imaging

    Laurids Stockert, Joseph Donovan, Herwig Baier
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Microbiology and Infectious Disease

    SIRT2 protects against Japanese encephalitis virus infection in mice

    Perumal Arumugam Desingu, Lavanya Dindi ... Nagalingam R Sundaresan
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Chromosomes and Gene Expression

    Genome-wide mapping of Cas9-induced sister chromatid exchange across single and over 200 genomic sites in human cells

    Peter Chovanec, Shiyang He, Yi Yin
    Sci-L3-Strand-seq uncovers sister chromatid exchange as a frequent hidden outcome of Cas9-induced breaks, revealing genome-editing consequences that are invisible to conventional sequencing, and can be associated with structural variations.
    1. Structural Biology and Molecular Biophysics

    Large-scale prospective evaluation of co-folding across hundreds of Mac1–ligand complexes and three virtual screens

    Jongbin Kim, Galen J Correy ... James S Fraser
    Co-folding methods accurately place and rank ligands within an optimization series, yet fail to separate true binders from docking false positives, suggesting complementary roles in drug discovery.
    1. Neuroscience

    Synaptic vesicle undocking induces low-frequency depression

    Melissa Silva, Federico F Trigo ... Alain Marty
    Low-frequency depression, an understudied form of synaptic plasticity, is proposed to reflect a reorganization of synaptic vesicles inside the readily releasable pool.
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    Lifestyle, Environment and Epigenetic Inheritance: A Collection of Articles

    Edited by Wei Yan

  2. Research Culture: From East to West – an early-career researcher’s voyage across continents

    Samuel C Eziuzor
  3. Close-up of an iris

    Episode 105: September 2026

    1. Cell Biology
    2. Computational and Systems Biology

    Philosophy of Biology: The power of theory in the life sciences

    Jacob L Fine, Finn Creeggan ... Adam MR Groh
    1. Genetics and Genomics

    Environmental Learning: How experience shapes individuality

    Bassem A Hassan

  6. Point of View: Scientific writing is not a murder mystery

    Charlotte A Dodson
    1. Neuroscience

    Visual Categorization: How monkeys carve up the visual world

    Binxu Wang
  8. See more Magazine articles

Categories

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