Highlights

We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Cell Biology

    SPEx: Compartment-Resolved Proteomics via Expansion Microscopy–Guided Microdissection

    Curdin A Franziscus, Alexia Ferrand ... Anne Spang
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Computational and Systems Biology

    High-frequency spike inference with particle Gibbs sampling

    Giovanni Diana, B Semihcan Sermet ... David A DiGregorio
    A Bayesian particle Gibbs framework enables unbiased spike time inference with millisecond resolution and jointly estimates uncertainties in both spike timing and model parameters from fast calcium imaging.
    1. Cell Biology

    Hsp70 is phosphorylated in a conserved response to DNA damage and contributes to cell cycle control

    Thomas Moss, Alexandra Wooldredge ... Shaeri Mukherjee
    A phosphorylation site on Hsp70 previously linked to pathogen activity functions endogenously in DNA damage responses and connects chaperone regulation to cell cycle control.
    1. Neuroscience

    Loose coupling between Ca2+ channels and release sensors as a synaptic correlate of higher order brain function

    Max Schwarze, Grit Bornschein ... Hartmut Schmidt
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Structural Biology and Molecular Biophysics

    Two Glu/Asp Residues Cooperatively Mediate an Early Step of ATP Hydrolysis in GHKL ATPases MutL and GyrB

    Kenji Fukui, Ayaka Shibuya ... Takato Yano
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Medicine

    Hyperactivated glycolysis drives spatially patterned Kupffer cell depletion in MASLD

    Jia He, Ran Li ... Zhao Shan
    Glycolytic activation directly drives Kupffer cell loss in early metabolic dysfunction-associated steatotic liver disease, highlighting a targetable metabolic vulnerability.
    1. Cancer Biology

    Molecular architecture of the tumor microenvironment caused by BRCA1 and BRCA2 somatic mutations in human lung adenocarcinoma

    Gaoming Liao, Xinbin Yang ... Gang Xu
    BRCA1/2 mutations rewire the lung adenocarcinoma microenvironment through distinct immune programs, with BRCA1-linked type I interferon signaling and CD8+ T activation contrasting BRCA2-linked MHC-II antigen presentation and CD4+ T differentiation.
    1. Ecology
    2. Physics of Living Systems

    Cognitive simplicity drives collective route improvements in homing pigeons

    Shoubhik Chandan Banerjee, Fritz A Francisco, Albert B Kao
    A navigational model exploring social learning strategies differing in cognitive complexity in homing pigeons shows that simple averaging sufficiently explains collective route improvements, without requiring cumulative cultural evolution.
    1. Neuroscience

    Multi-talker speech comprehension at different temporal scales in listeners with normal and impaired hearing

    Jixing Li, Qixuan Wang ... Zhiwu Huang
    Hearing impairment selectively disrupts neural tracking of speech at both short and long temporal scales during multi-speaker listening, while preserving intermediate linguistic processing.
    1. Neuroscience

    Inhibitory columnar feedback neurons are involved in motion processing in Drosophila

    Miriam Henning, Madhura D Ketkar ... Marion Silies
    Inhibitory GABAergic feedback neurons tune direction-selective motion signals in Drosophila, sharpening behavioral responses to rapidly changing visual stimuli and expanding canonical feedforward models of visual motion computation.
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Magazine

  1. Episode 103: May 2026

    1. Neuroscience

    Visual Perception: Insights into perceptual learning

    Zhong-Lin Lu
    1. Neuroscience

    Neuroendocrinology: Surging towards a better understanding of ovulation

    Lillian Rose, Alexander S Kauffman
    1. Cell Biology
    2. Neuroscience

    Auditory Hair Cells: Examining the role of lipids in hearing

    Yein Christina Park, Angela Ballesteros

  5. Point of View: Science under threat around the world

    Humberto J Debat
    1. Biochemistry and Chemical Biology

    Lipid Transport: How membranes shape up for lipid transfer

    Takashi Hirashima, Toshiya Endo
    1. Neuroscience

    Vestibular Hair Cells: Are kinocilia motile?

    Ruth Anne Eatock, Marina Kabirova
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