Highlights

  • Morphogenesis in fungi

    Glycolysis orchestrates morphogenesis and virulence in fungi by regulating the de novo biosynthesis of sulfur-containing amino acids.

    Dhrumi Shah, Nikita Rewatkar ... Sriram Varahan
    Research Article
  • Metal transport breakthrough

    Researchers have identified the transport protein used by the parasite Toxoplasma gondii to import iron and zinc.

    Dana Aghabi, Cecilia Gallego Rubio ... Clare R Harding
    Research Article
  • Social tolerance in macaques

    Species of macaques with high social tolerance have larger amygdalae than species with low social tolerance. Image credit: Sarah Silvère.

    Sarah Silvere, Julien Lamy ... Sebastien Ballesta
    Research Article
  • Research culture

    The Researcher Development Concordat has led to improvements in research culture in the UK, but there is still more to do.

    Robert AR Drake, Laura A Gray ... Joan Chang
    Feature Article
  • Written out of history

    Four women whose pioneering contributions to science have been largely overlooked.

    Lisa M Thomann, Julie Batut
    Feature Article
  • What is a Reviewed Preprint?

    Reviewed Preprints provide benefits to authors and to the wider scientific community.

    Inside eLife

Latest research

    1. Neuroscience

    Noradrenergic infraslow rhythm during sleep is the critical link between heart-rate dynamics and memory consolidation

    Sofie S Jacobsen, Allison B Morehouse ... Celia Kjaerby
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Boosting Hyperalignment Performance with Age-specific Templates

    Yuqi Zhang, Maria Ida Gobbini ... Ma Feilong
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Evolutionary Biology

    Heterozygote advantage cannot explain MHC diversity, but MHC diversity can explain heterozygote advantage

    Joshua L Cherry
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Neural Mechanisms of Willed Attention Control

    Changhao Xiong, Qiang Yang ... Mingzhou Ding
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Neuroscience

    The effect of physical activity on brain structure and cognitive function in the population-based cohort of LIFE-Adult-Study

    Polona Kalc, Rober Dahnke ... Christian Gaser
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Epidemiology and Global Health

    Repurposed small molecule toxin inhibitors neutralise a diversity of venoms from the Neotropical viperid snake genus Bothrops

    Rachel H Clare, Adam Westhorpe ... Nicholas R Casewell
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Microbiology and Infectious Disease

    Mycobacterium tuberculosis suppresses protective Th17 responses during infection

    Alex Zilinskas, Amir Balakhmet ... Sarah A Stanley
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Neuroscience

    Peripheral anatomy and central connectivity of proprioceptive sensory neurons in the Drosophila wing

    Ellen Lesser, Anthony J Moussa, John C Tuthill
    Comprehensive mapping of wing sensory neurons in Drosophila reveals that some proprioceptors make direct connections onto flight steering motor neurons, enabling rapid feedback control during flight.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    EPB41L4A-AS1 long noncoding RNA acts in both cis- and trans-acting transcriptional regulation and controls nucleolar biology

    Alan Monziani, Juan Pablo Unfried ... Igor Ulitsky
    EPB41L4A-AS1, a highly expressed snoRNA host long noncoding RNA, has multiple functions, positive regulation in cis of the EPB41L4A gene and a trans-acting role in supporting proper nucleolar biology.
    1. Cell Biology

    Large-scale identification of plasma membrane repair proteins revealed spatiotemporal cellular responses to plasma membrane damage

    Yuta Yamazaki, Keiko Kono
    Proteome-scale visual screening in budding yeast provides a functional catalog of plasma membrane repair proteins and reveals the coordinated cellular responses at the bud tip and the damage site.