Highlights

  • From disorder to stability

    An intrinsically disordered region in a scaffolding protein called Zasp52 is required to stabilize Z-discs in the indirect flight muscle in Drosophila.

    Nikolai Ho, Frieder Schöck
    Reviewed Preprint
  • Context-dependent behavior

    A region of the brain called the retrosplenial cortex has an important role in integrating contextual information and sensory stimuli in mice.

    Pol Bech, Robin F Dard ... Carl CH Petersen
    Reviewed Preprint Updated
  • Seeing movement

    Inhibitory feedback from GABAergic interneurons C2 and C3 is tied to neural computation of moving visual stimuli in Drosophila.

    Miriam Henning, Madhura D Ketkar ... Marion Silies
    Research Article
  • Publish-review-curate at eLife

    eLife is rethinking how research is reviewed and published.

    Timothy E Behrens, Yamini Dalal, Diane M Harper
    Editorial
  • Science under threat

    How should the scientific community respond to ideological attacks on science?

    Humberto J Debat
    Feature Article
  • How to respond to peer reviewers

    Responding to peer reviews is a crucial part of publishing, but early-career researchers are rarely taught about it.

    Eric Kalkhoven, Manon Kluijtmans
    Feature Article

Latest research

    1. Genetics and Genomics

    Autosomal Allelic Inactivation: Variable Replication and Dosage Sensitivity

    Michael B Heskett, Athanasios E Vouzas ... Mathew J Thayer
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Solid
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Enteropathogenic E. coli-mediated Fast and Coordinated Ca2+ responses regulate NF-κB activation

    Fangrui Guo, Roberto Ornelas Guevara ... Guy Tran Van Nhieu
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Ribosomal RNA methylation by GidB modulates discrimination of mischarged tRNA

    Zhuo Bi, Yu-Xiang Chen ... Babak Javid
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Cell Biology
    2. Chromosomes and Gene Expression

    A genetic toolkit for stable episomal transgenesis in the anaerobic gut parasite Blastocystis ST7-B

    M Rey Toleco, Kevin SW Tan, Mark van der Giezen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Compelling
    1. Neuroscience

    Boosting Hyperalignment Performance with Age-specific Templates

    Yuqi Zhang, Maria Ida Gobbini ... Ma Feilong
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Microbiology and Infectious Disease

    Quantitative RNA pseudouridine landscape reveals dynamic modification patterns and evolutionary conservation across bacterial species

    Letong Xu, Shenghai Shen ... Xin Deng
    Transcriptome-wide profiling of bacterial RNA pseudouridylation maps modification landscapes and nominates candidate regulatory sites, offering a resource and foundation for future mechanistic studies of Ψ function in bacteria.
    1. Medicine
    2. Structural Biology and Molecular Biophysics

    Direct MRI of collagen

    Jason Daniel Van Schoor, Markus Weiger ... Klaas P Pruessmann
    The direct observation of collagen using magnetic resonance imaging is possible, presenting a new method to study the protein in vivo.
    1. Neuroscience

    Orco regulates the circadian activity of pheromone-sensitive olfactory receptor neurons in hawkmoths

    Aditi Vijayan, Mauro Forlino ... Monika Stengl
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Compelling
    • Incomplete
    1. Genetics and Genomics
    2. Neuroscience

    Learning is a fundamental source of individuality

    Riddha Manna, Johanni Brea ... Ana Marija Jakšić
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling