Highlights

  • Microglia on the move

    Microglia adopt fundamentally different strategies for surveilling the health of neurons during chronic neurodegeneration.

    Sunitha Subhramanian, Olga Bocharova ... Ilia V Baskakov
    Research Article

  • Shaping male behaviours in fish

    Estrogens produced in the brain increase neural sensitivity to testicular androgens, and thus elicit male-typical behaviors, in the Japanese rice fish.

    Yuji Nishiike, Shizuku Maki ... Kataaki Okubo
    Research Article

  • X-rays impact gene expression

    Exposing the wing discs of Drosophila to X-rays leads to heterogenous changes in gene expression that are related to cell-cycle status and cell location.

    Joyner Cruz, Willam Y Sun ... Iswar K Hariharan
    Reviewed Preprint Updated

  • Research culture

    The Researcher Development Concordat has led to improvements in research culture in the UK, but there is still more to do.

    Robert AR Drake, Laura A Gray ... Joan Chang
    Feature Article

  • Where theory meets biology

    eLife author Veronika Koren, a computational neuroscientist, answers questions about her work on efficient coding.

    Inside eLife

  • What is a Reviewed Preprint?

    Reviewed Preprints provide benefits to authors and to the wider scientific community.

    Inside eLife
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Neuroscience

    Sex-specific exploration accounts for differences in valence learning in male and female mice

    Heike Schuler, Eshaan S Iyer ... Rosemary C Bagot
    Deep behavioral phenotyping reveals that performance readouts from single-valence conditioning are biased by baseline sex differences in exploration, and mixed-valence conditioning provides a clearer assessment of learning in both sexes.
    1. Chromosomes and Gene Expression

    Impacts of DNA Methylation on H2A.Z Deposition and Nucleosome Stability

    Rochelle M Shih, Yasuhiro Arimura ... Hironori Funabiki
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Spontaneous fluctuations in global connectivity reflect transitions between states of high and low prediction error

    Paul C Bogdan, Shenyang Huang ... Roberto Cabeza
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Massively parallel reporter assay for mapping gene-specific regulatory regions at single nucleotide resolution

    Alastair J Tulloch, Ryan N Delgado ... Constance L Cepko
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Multi-talker speech comprehension at different temporal scales in listeners with normal and impaired hearing

    Jixing Li, Qixuan Wang ... Zhiwu Huang
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    1. Developmental Biology
    2. Neuroscience

    The Fd4 transcription factor translates transient spatial cues in progenitors into long-term lineage identity

    Sen-Lin Lai, Chris Q Doe
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Microbiology and Infectious Disease

    Activation of the Spx redox sensor counters cysteine-driven Fe(II) depletion under disulfide stress

    Abigail G Hall, Abdulelah A Alqarzaee ... Vinai C Thomas
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Neuroscience

    Dynamics of mesoscale brain network during visual discrimination learning revealed by chronic, large-scale single-unit recording

    Tian-Yi Wang, Chengcong Feng ... Zhengtuo Zhao
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Doubling dolutegravir dosage reduces the viral reservoir in ART-treated people with HIV

    Céline Fombellida-Lopez, Aurelija Valaitienė ... Gilles Darcis
    In a randomized trial, ART intensification by doubling the dolutegravir dosage in people with HIV stably suppressed on dolutegravir-based ART reduced levels of four HIV reservoir markers in peripheral blood.
    1. Computational and Systems Biology
    2. Neuroscience

    Computational modelling identifies key determinants of subregion-specific dopamine dynamics in the striatum

    Aske Ejdrup, Jakob Kisbye Dreyer ... Ulrik Gether
    A computational model of the striatal dopamine system predicts transporter expression and organisation as key determinants of regional striatal dopamine dynamics and distinct signal decoding by D1 and D2 receptors.
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Magazine

    1. Developmental Biology

    Limb Patterning: The cellular logic of limb regeneration

    Matthew Cherubino, Catherine D McCusker
    1. Neuroscience

    Aging: Linking neuron-glia interactions and longevity

    Michael Pokrass, Nan Hao

  3. Research Culture: Going beyond compliance to build on the Researcher Development Concordat

    Robert AR Drake, Laura A Gray ... Joan Chang
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Chromosomes: Finding a role for non-coding DNA in trypanosomes

    Markus R Schmidt
    1. Cancer Biology
    2. Cell Biology

    Chemotherapy: Lipid balance and chemoresistance in cancer cells

    Kaori Kanemaru, Yoshikazu Nakamura
    1. Genetics and Genomics
    2. Physics of Living Systems

    Raman Spectroscopy: Probing the proteome

    Wei-Hsiang Lin, Chia-Liang Cheng
    1. Genetics and Genomics
    2. Neuroscience

    Opioid Use Disorder: Identifying new targets in the fight against opioids

    Fernanda Laezza
  8. See more Magazine articles

Categories

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