Highlights

  • Symbionts shape pest traits

    Novel endosymbiotic bacteria have contrasting effects on the performance and dispersal of Russian wheat aphids and on the severity of damage caused to cereal host plants.

    Xinyue Gu, Alex Gill ... Ary A Hoffmann
    Reviewed Preprint Updated

  • Neurosecretory connections

    Connectomic and transcriptomic analyses reveal the anatomical and functional organisation of neurosecretion in the Drosophila brain.

    Theresa H McKim, Jayati Gera ... Meet Zandawala
    Research Article

  • Replication in Drosophila studies

    An analysis of 400 articles on the immune response in Drosophila highlights a need for caution regarding the replicability of certain claims.

    Hannah Westlake, Fabrice David ... Bruno Lemaitre
    Reviewed Preprint Updated

  • Hypoxia to healthspan

    Genetic tools highlight potential signalling components underlying hypoxia-induced longevity in C. elegans.

    Elizabeth S Kitto, Shijiao Huang ... Scott F Leiser
    Reviewed Preprint Updated

  • AI in research communication

    eLife has partnered on a number of projects harnessing AI for improving human and machine reader engagement with research.

    Inside eLife

  • Explore our new collection

    Delve into leading research on Lifestyle, Environment and Epigenetic Inheritance.

    Collection
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Biochemistry and Chemical Biology

    NUDT2 loss defines quantitative limits for dinucleoside polyphosphate action on the cGAS–STING–TBK1 axis

    Paul Weiland, Renuka Dharani Shivakumar ... Gert Bange
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Physics of Living Systems

    Mechanics and fate stochasticity shape stem cell distribution in tissues

    Johannes C Krämer, Edouard Hannezo, Jens Elgeti
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Immunology and Inflammation

    Macrophages drive inguinal fat pad and lymph node remodelling in response to peripheral inflammation

    Robin Bartolini, Deepika Sharma ... Gerard J Graham
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A proteome-wide biochemical screen defines binding determinants of the core autophagy protein LC3B

    Jennifer Kosmatka, Cong Liu ... Amy E Keating
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience
    2. Physiology

    Fitness Level, but not Sex, affects Exercise-Induced Pain Modulation

    Janne I Nold, Tahmine Fadai ... Christian Büchel
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Neuroscience

    Reduced dorsal CA1 activity limits retention of the temporal component of declarative memory in the Cntnap2 knockout mouse model of autism

    Elise Caitlin Rawlinson, Michael Hugh McCullough ... Nathalie Dehorter
    Restoring hippocampal CA1 activation during temporal gaps is sufficient to rescue long-term memory in a mouse model of autism.
    1. Biochemistry and Chemical Biology

    Gluconeogenic compensation renders glycogen phosphorylase non-essential as an insecticidal target in Plutella xylostella

    Yifei Zhou, Yanqi Kang ... Jiyuan Liu
    Gluconeogenesis rescues insects from glycogen phosphorylase suppression, establishing metabolic redundancy as a key consideration for insecticide target selection.
    1. Cell Biology
    2. Immunology and Inflammation

    Allosteric disulfide control of ligand binding and endocytosis of KIR2DL4, the natural killer cell receptor for HLA-G

    Sumati Rajagopalan, Joyce Chiu ... Eric O Long
    Allosteric transition between two disulfide configurations of NK cell receptor KIR2DL4 is a functional switch that controls receptor residence at the cell surface for binding and internalization of soluble HLA-G.
    1. Cancer Biology

    JAK-STAT pathway heterogeneity governs immunotherapy response in breast cancer

    Jianbo Zhou, Heng Zhang ... Fu Peng
    Multi-omics investigation identifies cell-type JAK-STAT heterogeneity as a predictive biomarker for PD-1 blockade in breast cancer.
    1. Physics of Living Systems

    Anatomy and mechanics of tsetse fly blood feeding

    Stephan Löwe, Laura Hauf ... Markus Engstler
    A saw-like proboscis, forceful pulling movements, and precise targeting of softer skin sites allow tsetse flies to draw blood from remarkably diverse vertebrate hosts.
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    Lifestyle, Environment and Epigenetic Inheritance: A Collection of Articles

    Edited by Wei Yan

  2. Research Culture: From East to West – an early-career researcher’s voyage across continents

    Samuel C Eziuzor
  3. Close-up of an iris

    Episode 105: September 2026

    1. Cell Biology
    2. Computational and Systems Biology

    Philosophy of Biology: The power of theory in the life sciences

    Jacob L Fine, Finn Creeggan ... Adam MR Groh
    1. Genetics and Genomics

    Environmental Learning: How experience shapes individuality

    Bassem A Hassan

  6. Point of View: Scientific writing is not a murder mystery

    Charlotte A Dodson
    1. Neuroscience

    Visual Categorization: How monkeys carve up the visual world

    Binxu Wang
  8. See more Magazine articles

Categories

  1. Biochemistry and Chemical Biology
  2. Cancer Biology
  3. Cell Biology
  4. Chromosomes and Gene Expression
  5. Computational and Systems Biology
  6. Developmental Biology
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  11. Immunology and Inflammation
  12. Medicine
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