Highlights

  • Eed and craniofacial development

    Eed, a subunit of the enzyme PRC2, controls important processes in craniofacial development after induction of the neural crest.

    Tim Casey-Clyde, S John Liu ... David R Raleigh
    Research Article

  • The power of pyruvate

    The metabolic fate of a nutrient called pyruvate determines how big cells become.

    Ashish G Toshniwal, Geanette Lam ... Jared Rutter
    Research Article

  • Microglia on the move

    Microglia adopt fundamentally different strategies for surveilling the health of neurons during chronic neurodegeneration.

    Sunitha Subhramanian, Olga Bocharova ... Ilia V Baskakov
    Reviewed Preprint Updated

  • Phosphate buffering

    Lysosome-related vacuoles control the metabolism of inorganic polyphosphates to stabilize the concentration of phosphate in the cytosol.

    Samuel Bru, Lydie Michaillat Mayer ... Andreas Mayer
    Research Article

  • Equity, diversity and inclusion

    eLife has published its 10th report on its work to address inequities in research and publishing.

    Inside eLife

  • The SAFE Labs Handbook

    New handbook could help group leaders to improve research culture in their labs.

    Erika Donà, James M Gahan ... Philip Coen
    Feature Article
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Cell Biology

    Altair-LSFM: A High-Resolution, Easy-to-Build Light-Sheet Microscope for Sub-Cellular Imaging

    John Haug, Seweryn Gałecki ... Kevin M Dean
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Neuroscience

    Functional Connectivity-based Attractor Dynamics in Rest, Task, and Disease

    Robert Englert, Balint Kincses ... Tamas Spisak
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Neuroscience

    Projection-specific integration of convergent thalamic and retrosplenial signals in the presubicular head direction cortex

    Louis Richevaux, Dongkyun Lim ... Desdemona Fricker
    Nonlinear dendritic integration in single presubicular neurons provides a mechanism for combining vestibular-based head-direction signals and visual landmark signals to anchor the brain’s internal compass.
    1. Structural Biology and Molecular Biophysics

    Nucleosome wrapping energy in CpG islands and the role of epigenetic base modifications

    Rasa Giniūnaitė, Rahul Sharma ... Daiva Petkevičiūtė-Gerlach
    CpG density and epigenetic modification state modulate DNA mechanics, altering its intrinsic compatibility with nucleosome formation.
    1. Immunology and Inflammation

    Class A scavenger receptor MARCO negatively regulates Ace expression and aldosterone production

    Conan JO O'Brien, Giorgio Ratti ... Ana I Domingos
    Loss of class A scavenger receptor MARCO results in elevated lung Ace expression and elevated plasma aldosterone concentrations in male mice, demonstrating an endocrine function of this immune scavenger receptor.
    1. Chromosomes and Gene Expression

    Structural characterisation of chromatin remodelling intermediates supports linker DNA dependent product inhibition as a mechanism for nucleosome spacing

    Amanda L Hughes, Ramasubramanian Sundaramoorthy, Tom Owen-Hughes
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Phospholipid scramblase 1 (PLSCR1) regulates interferon-lambda receptor 1 (IFN-λR1) and IFN-λ signaling in influenza A virus (IAV) infection

    Alina Xiaoyu Yang, Lisa Ramos-Rodriguez ... Yang Zhou
    PLSCR1 is an IFN-λ-stimulated gene that enhances IFN-λR1 expression at both transcriptional and protein level, highlighting the potential for targeting PLSCR1 pathways in anti-influenza therapy.
    1. Developmental Biology

    Genetic and physical interactions reveal overlapping and distinct contributions to meiotic double-strand break formation in C. elegans

    Marilina Raices, Fabiola Balmir ... Judith L Yanowitz
    Revised
    Reviewed Preprint v3
    Updated
    • Useful
    • Solid
    1. Neuroscience

    Daily life fluctuations in affect predict within-person changes in a real-world measure of cognitive processing speed

    Sol Fittipaldi, Vanessa Teckentrup ... Claire M Gillan
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Developmental Biology

    Dorsoventral-mediated Shh induction is required for axolotl limb regeneration

    Sakiya Yamamoto, Saya Furukawa ... Akira Satoh
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
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Magazine

    1. Cancer Biology

    Breast Cancer: Slowing the growth of drug-resistant tumors

    Yingyi Zhang, Qianying Lu
    1. Neuroscience

    Experience-Dependent Plasticity: The little brain supervises learning in the big brain

    Martha Garcia, Mark Wagner
    1. Microbiology and Infectious Disease

    Tuberculosis: A surprising new hiding place for a dangerous pathogen

    Sheetal Gandotra, Yogendra Singh
  4. Blurry photo of a flag, fish and a bird in the water

    Episode 101: December 2025

    1. Neuroscience

    Neuronal Activity: Keeping track of moving targets

    Renata Batista-Brito, Geoffrey Terral

  6. Research Culture: The SAFE Labs Handbook as a tool for improving lab culture

    Erika Donà, James M Gahan ... Philip Coen
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Metabolism: How one nutrient controls cell size

    Angela Montero, Lydia WS Finley
  8. See more Magazine articles

Categories

  1. Biochemistry and Chemical Biology
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  4. Chromosomes and Gene Expression
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  12. Medicine
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