Highlights

  • Drug-resistant sleeping sickness

    Mutations in a water channel called TbAQP2 make the parasite that causes sleeping sickness resistant to drugs. Image: Jessica Eggers (CC BY 4.0).

    Modestas Matusevicius, Robin A Corey ... Simone N Weyand
    Reviewed Preprint Updated

  • Modelling archaeal membranes

    Archaea use single-headed and double-headed lipids to construct cell membranes that are both flexible and capable of withstanding extreme environments.

    Miguel Amaral, Felix Frey ... Anđela Šarić
    Research Article

  • ITP signaling and homeostasis

    The ion transport peptide (ITP) signaling system relies on a guanylate cyclase receptor to maintain homeostasis in Drosophila.

    Jayati Gera, Marishia Agard ... Meet Zandawala
    Research Article

  • How we understand each other

    eLife author Joe Barnby answers questions about a study that explored how humans navigate social interactions.

    Inside eLife

  • Focus Issue: Trained Immunity

    The articles in this focus issue discuss progress towards a better understanding of memory in the innate immune system, and efforts to develop new vaccines and therapeutics based on “trained immunity”.

    Collection

  • No change for astroctyes

    Genetically removing the RNA-binding protein PTBP1 from astrocytes does not convert them into neurons, contrary to previous claims.

    Min Zhang, Naoto Kubota ... Sika Zheng
    Reviewed Preprint Updated
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Computational and Systems Biology
    2. Physics of Living Systems

    Atypical collective oscillatory activity in cardiac tissue uncovered by optogenetics

    Alexander S Teplenin, Nina N Kudryashova ... Tim De Coster
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics

    A high-resolution analysis of arrestin2 interactions responsible for CCR5 endocytosis

    Ivana Petrovic, Samit Desai ... Stephan Grzesiek
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Structural Biology and Molecular Biophysics

    Multi-barrier unfolding of the double-knotted protein, TrmD–Tm1570, revealed by single-molecule force spectroscopy and molecular dynamics

    Fernando Bruno da Silva, Szymon Niewieczerzal ... Joanna I Sulkowska
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Developmental Biology

    HSD17B7 is required for Auditory Function by Regulating Cholesterol Synthesis in Sensory Hair Cells

    Yuqian Shen, Ziyang Wang ... Dong Liu
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Microbiology and Infectious Disease

    HIV-specific CD8+ T-cell proliferative response 24 weeks after early antiretroviral therapy initiation predicts the subsequent reduction of the viral reservoir

    Pien M van Paassen, Alexander O Pasternak ... the Netherlands Cohort Study on Acute HIV Infection (NOVA) study team
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Cell Biology

    Roles of G-protein coupled receptors and mechanosensitive ion channels in pressure-induced chronotropy of lymphatic vessels

    Michael J Davis, Hae Jin Kim ... Scott D Zawieja
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    • Incomplete
    1. Neuroscience

    A deep learning approach for the analysis of birdsong

    Therese MI Koch, Ethan S Marks, Todd F Roberts
    An open-source deep learning toolkit performs accurate annotation and similarity scoring of zebra finch song, along with comprehensive feature extraction, enabling consistent, interpretable comparisons of vocal phenotypes across research groups.
    1. Neuroscience

    Mother-child dyadic interactions shape the developing social brain and Theory of Mind in young children

    Lei Li, Jinming Xiao ... Xujun Duan
    Children’s social cognitive development emerges from the dynamic interplay of neural maturation, parental caregiving, and dyadic brain-to-brain synchrony.
    1. Cell Biology
    2. Computational and Systems Biology

    Extrusion-modulated DnaA activity oscillations coordinate DNA replication with biomass growth

    Dengjin Li, Hai Zheng ... Chenli Liu
    Chromosome-driven DnaA activity oscillations, modulated by DNA-binding proteins, enable bacteria to coordinate DNA replication with biomass growth independently of transcriptional regulation.
    1. Plant Biology

    Fifteenth century CE Bolivian maize reveals genetic affinities with ancient Peruvian maize

    Huan Chen, Amy Baetsen-Young ... Gabriel Wrobel
    Genomic evidence from 15th-century Bolivian maize reveals similarity to Central Andean maize from Peru, and pre-Inca and Inca-era breeding that enhanced maize development through selection within Andean agricultural networks.
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Magazine

    1. Genetics and Genomics

    Transgenerational Epigenetic Inheritance: Twists and turns in the story of learned avoidance

    Lesley T MacNeil
    1. Medicine
    2. Immunology and Inflammation
    3. Microbiology and Infectious Disease

    Focus Issue: Trained Immunity

    Edited by Satyajit Rath et al.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Focus Issue: Evolving our understanding of trained immunity

    Eva Kaufmann, Yahya Sohrabi ... Jos WM van der Meer
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Bacteriology: How Shigella tackles host defences

    Yizhou Huang, Teresa LM Thurston
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Chromosomes: Exploring a crossroads in the aging process

    Kiyan Shabestary, Daniel E Gottschling
    1. Neuroscience

    Neuronal Migration: How hunger guides new brain cells to their destination

    Fang-Shin Nian, Laurent Nguyen
    1. Neuroscience

    Primate Research: Probing the staying power of chemogenetics

    Maria Puchik, Igor Kagan
  8. See more Magazine articles

Categories

  1. Biochemistry and Chemical Biology
  2. Cancer Biology
  3. Cell Biology
  4. Chromosomes and Gene Expression
  5. Computational and Systems Biology
  6. Developmental Biology
  7. Ecology
  8. Epidemiology and Global Health
  9. Evolutionary Biology
  10. Genetics and Genomics
  11. Immunology and Inflammation
  12. Medicine
  13. Microbiology and Infectious Disease
  14. Neuroscience
  15. Physics of Living Systems
  16. Plant Biology
  17. Stem Cells and Regenerative Medicine
  18. Structural Biology and Molecular Biophysics
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