Highlights

  • X-rays impact gene expression

    Exposing the wing discs of Drosophila to X-rays leads to heterogenous changes in gene expression that are related to cell-cycle status and cell location.

    Joyner Cruz, William Y Sun ... Iswar K Hariharan
    Research Article

  • Reprogramming progenitor cells

    Progenitor cells destined to become glial cells can be reprogrammed to become corticospinal-like neurons

    Abdulkadir Ozkan, Hari K Padmanabhan ... Jeffrey D Macklis
    Research Article

  • Nanosprings probe motor proteins

    DNA nanosprings can measure stall forces in kinesin motor proteins, highlighting their potential as a new tool for force spectroscopy in biophysics.

    Nobumichi Takamatsu, Hiroko Furumoto ... Kumiko Hayashi
    Reviewed Preprint Updated

  • Research culture

    The Researcher Development Concordat has led to improvements in research culture in the UK, but there is still more to do.

    Robert AR Drake, Laura A Gray ... Joan Chang
    Feature Article

  • Where theory meets biology

    eLife author Veronika Koren, a computational neuroscientist, answers questions about her work on efficient coding.

    Inside eLife

  • What is a Reviewed Preprint?

    Reviewed Preprints provide benefits to authors and to the wider scientific community.

    Inside eLife
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Neuroscience

    Dynamic updating of spatial working memory across eye movements: a computational investigation of transsaccadic integration

    Sijia Zhao, Thomas Parr ... Masud Husain
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Computational and Systems Biology

    Leveraging Disease Association Degree for High-Accuracy MicroRNA Target Prediction

    Baiming Chen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Developmental Biology

    Probing metazoan polyphosphate biology using Drosophila reveals novel and conserved polyP functions

    Sunayana Sarkar, Harsha Sharma ... Manish Jaiswal
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Multiple modes of cholesterol translocation in the human Smoothened receptor

    Prateek Bansal, Maia Kinnebrew ... Diwakar Shukla
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    • Solid
    1. Cell Biology

    PHD1-dependent hydroxylation of RepoMan (CDCA2) on P604 modulates the control of mitotic progression

    Jimena Druker, Hao Jiang ... Angus I Lamond
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Neuroscience

    High-Fidelity Neural Speech Reconstruction through an Efficient Acoustic-Linguistic Dual-Pathway Framework

    Jiawei Li, Chunxu Guo ... Yuanning Li
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Developmental Biology

    Mouse skeletal muscle satellite cells co-opt the tenogenic gene Scleraxis to instruct regeneration

    Yun Bai, Tyler Harvey ... Chen-Ming Fan
    Muscle stem cells repurpose the tenogenic factor Scx to establish a muscle-specific transcriptional program that sustains stem cell expansion, migration, differentiation, fusion, self-renewal, and survival.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Distinct chromatin regulators downmodulate meiotic axis protein deposition and DNA break induction at chromosome ends

    Adhithi R Raghavan, Kieron May ... Andreas Hochwagen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Deep learning-driven characterization of single cell tuning in primate visual area V4 supports topological organization

    Konstantin F Willeke, Kelli Restivo ... Andreas S Tolias
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Resolving synaptic events using subsynaptically targeted GCaMP8 variants

    Jiawen Chen, Junhao Lin ... Dion Dickman
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
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Magazine

    1. Neuroscience

    Brain Mapping: Redefining borders in the sensorimotor cortex

    Sylvain Crochet
    1. Structural Biology and Molecular Biophysics

    Receptor Proteins: Lipids challenge ligands to control receptors

    Adam JM Wollman
    1. Medicine
    2. Structural Biology and Molecular Biophysics

    Medical Imaging: MRI sets its sights on collagen

    Fritz Schick
    1. Developmental Biology

    Limb Patterning: The cellular logic of limb regeneration

    Matthew Cherubino, Catherine D McCusker
    1. Neuroscience

    Aging: Linking neuron-glia interactions and longevity

    Michael Pokrass, Nan Hao

  6. Research Culture: Going beyond compliance to build on the Researcher Development Concordat

    Robert AR Drake, Laura A Gray ... Joan Chang
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Chromosomes: Finding a role for non-coding DNA in trypanosomes

    Markus R Schmidt
  8. See more Magazine articles

Categories

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