Highlights

  • No change for astroctyes

    Genetically removing the RNA-binding protein PTBP1 from astrocytes does not convert them into neurons, contrary to previous claims.

    Min Zhang, Naoto Kubota ... Sika Zheng
    Research Article

  • Eed and craniofacial development

    Eed, a subunit of the enzyme PRC2, controls important processes in craniofacial development after induction of the neural crest.

    Tim Casey-Clyde, S John Liu ... David R Raleigh
    Research Article

  • Phosphate buffering

    Lysosome-related vacuoles control the metabolism of inorganic polyphosphates to stabilize the concentration of phosphate in the cytosol.

    Samuel Bru, Lydie Michaillat Mayer ... Andreas Mayer
    Research Article

  • How we understand each other

    eLife author Joe Barnby answers questions about a study that explored how humans navigate social interactions.

    Inside eLife

  • Focus Issue: Trained Immunity

    The articles in this focus issue discuss progress towards a better understanding of memory in the innate immune system, and efforts to develop new vaccines and therapeutics based on “trained immunity”.

    Collection

  • Equity, diversity and inclusion

    eLife has published its 10th report on its work to address inequities in research and publishing.

    Inside eLife
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Neuroscience

    Virtual Brain Inference (VBI), a flexible and integrative toolkit for efficient probabilistic inference on whole-brain models

    Abolfazl Ziaeemehr, Marmaduke Woodman ... Meysam Hashemi
    The Virtual Brain Inference (VBI) toolkit enables efficient, accurate, and scalable Bayesian inference over whole-brain network models, improving parameter estimation, uncertainty quantification, and predictive modeling across neuroimaging modalities toward precision medicine.
    1. Ecology

    Range geography and temperature variability explain cross-continental convergence in range and phenology shifts in a model insect taxon

    Catherine Sirois-Delisle, Susan CC Gordon, Jeremy Kerr
    Across continents, half of odonate species shifted both ranges and phenologies in response to climate warming, with southern species and those experiencing less temperature variability shifting ranges more strongly.
    1. Cancer Biology

    Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics

    Inbal Avraham-Davidi, Simon Mages ... Aviv Regev
    An integrative analysis of scRNA-seq and spatial transcriptomics provides complementary views into the biology of pre-clinical colorectal cancer models in mice with possible applications to the human system.
    1. Cell Biology

    THE FAM53C/DYRK1A axis regulates the G1/S transition of the cell cycle

    Taylar Hammond, Jong Bin Choi ... Julien Sage
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Microbiology and Infectious Disease

    Loss of the s2U tRNA modification induces antibiotic tolerance and is linked to changes in ribosomal protein expression

    Katherine L Cotten, Abigail McShane ... Kimberly M Davis
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    1. Neuroscience

    Information, certainty, and learning

    Justin A Harris, Charles R Gallistel
    Revised
    Reviewed Preprint v3
    Updated
    • Fundamental
    • Compelling
    1. Genetics and Genomics
    2. Cancer Biology

    Early Diagnosis and Prognostic Prediction of Colorectal Cancer through Plasma Methylation Regions

    Lingqin Zhu, Lang Yang ... Jianqiu Sheng
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Defining the chromatin-associated protein landscapes on Trypanosoma brucei repetitive elements using synthetic TALE proteins

    Roberta Carloni, Tadhg Devlin ... Robin C Allshire
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the bicarbonate receptor GPR30

    Shota Kaneda, Airi Jo-Watanabe ... Osamu Nureki
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Genetics and Genomics
    2. Neuroscience

    Impaired excitability of fast-spiking neurons in a novel mouse model of KCNC1 epileptic encephalopathy

    Eric R Wengert, Sophie R Liebergall ... Ethan M Goldberg
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
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Magazine

    1. Neuroscience

    Experience-Dependent Plasticity: The little brain supervises learning in the big brain

    Martha Garcia, Mark Wagner
    1. Microbiology and Infectious Disease

    Tuberculosis: A surprising new hiding place for a dangerous pathogen

    Sheetal Gandotra, Yogendra Singh
  3. Blurry photo of a flag, fish and a bird in the water

    Episode 101: December 2025

    1. Neuroscience

    Neuronal Activity: Keeping track of moving targets

    Renata Batista-Brito, Geoffrey Terral

  5. Research Culture: The SAFE Labs Handbook as a tool for improving lab culture

    Erika Donà, James M Gahan ... Philip Coen
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Metabolism: How one nutrient controls cell size

    Angela Montero, Lydia WS Finley
    1. Genetics and Genomics

    Transgenerational Epigenetic Inheritance: Twists and turns in the story of learned avoidance

    Lesley T MacNeil
  8. See more Magazine articles

Categories

  1. Biochemistry and Chemical Biology
  2. Cancer Biology
  3. Cell Biology
  4. Chromosomes and Gene Expression
  5. Computational and Systems Biology
  6. Developmental Biology
  7. Ecology
  8. Epidemiology and Global Health
  9. Evolutionary Biology
  10. Genetics and Genomics
  11. Immunology and Inflammation
  12. Medicine
  13. Microbiology and Infectious Disease
  14. Neuroscience
  15. Physics of Living Systems
  16. Plant Biology
  17. Stem Cells and Regenerative Medicine
  18. Structural Biology and Molecular Biophysics
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