Highlights

  • X-rays impact gene expression

    Exposing the wing discs of Drosophila to X-rays leads to heterogenous changes in gene expression that are related to cell-cycle status and cell location.

    Joyner Cruz, William Y Sun ... Iswar K Hariharan
    Research Article

  • Reprogramming progenitor cells

    Progenitor cells destined to become glial cells can be reprogrammed to become corticospinal-like neurons

    Abdulkadir Ozkan, Hari K Padmanabhan ... Jeffrey D Macklis
    Research Article

  • Nanosprings probe motor proteins

    DNA nanosprings can measure stall forces in kinesin motor proteins, highlighting their potential as a new tool for force spectroscopy in biophysics.

    Nobumichi Takamatsu, Hiroko Furumoto ... Kumiko Hayashi
    Reviewed Preprint Updated

  • Research culture

    The Researcher Development Concordat has led to improvements in research culture in the UK, but there is still more to do.

    Robert AR Drake, Laura A Gray ... Joan Chang
    Feature Article

  • Where theory meets biology

    eLife author Veronika Koren, a computational neuroscientist, answers questions about her work on efficient coding.

    Inside eLife

  • What is a Reviewed Preprint?

    Reviewed Preprints provide benefits to authors and to the wider scientific community.

    Inside eLife
We liked the idea of having an open 'conversation' with the reviewers during the process, and having the chance to polish the manuscript by following the editors and reviewers’ recommendations without the threat of rejection.

Patrick Allard, UCLA and eLife author

Researchers explain why they published in eLife

Latest research

    1. Neuroscience

    E3 Ubiquitin Ligase Highwire/Phr1 Phase Separation Mediates Endocytic Control of JNK Signaling in Drosophila Neurons

    Srikanth Pippadpally, Anjali Bisht ... Vimlesh Kumar
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Microbiology and Infectious Disease

    ZFT is the major iron and zinc transporter in Toxoplasma gondii

    Dana Aghabi, Cecilia Gallego Rubio ... Clare R Harding
    Identification of the mechanism of iron and zinc uptake by Toxoplasma gondii to support parasite replication and metabolism.
    1. Developmental Biology

    Dorsoventral-mediated Shh induction is required for axolotl limb regeneration

    Sakiya Yamamoto, Saya Furukawa ... Akira Satoh
    Dorsoventral contact in axolotl limb blastemas induces Shh, showing how positional identities cooperate to drive the regeneration process.
    1. Immunology and Inflammation

    Ly6G+ granulocytes-derived IL-17 limits protective host responses and promotes tuberculosis pathogenesis

    Priya Sharma, Raman Deep Sharma ... Dhiraj Kumar
    The IL-17–Ly6G⁺ granulocyte axis is a key driver and correlate of tuberculosis pathology and represents a potential target for improving vaccine-induced protection and therapeutic outcomes.
    1. Cell Biology

    A high-resolution, easy-to-build light-sheet microscope for subcellular imaging

    John Haug, Seweryn Gałecki ... Kevin M Dean
    An accessible light-sheet microscope delivers subcellular-resolution, multicolor volumetric, and live-cell imaging, lowering barriers to state-of-the-art performance.
    1. Neuroscience

    Simple Methods to Acutely Measure Multiple Timing Metrics among Sexual Repertoire of Male Drosophila

    Yutong Song, Dongyu Sun ... Woo Jae Kim
    Not revised
    Reviewed Preprint v1
    • Useful
    • Convincing
    1. Neuroscience

    Multiple event segmentation mechanisms in the human brain

    Tan T Nguyen, Joset A Etzel ... Jeffrey M Zacks
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Decoding state specific connectivity during speech production and perception

    Yasamin Esmaeili, Amirhossein Khalilian-Gourtani ... Adeen Flinker
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Microbiology and Infectious Disease

    A Conserved Mycobacterial Nucleomodulin Hijacks the Host COMPASS Complex to Reprogram Pro-Inflammatory Transcription and Promote Intracellular Survival

    Liu Chen, Baojie Duan ... Aizhen Guo
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Neuroscience
    2. Evolutionary Biology

    Complex environmental cycles reveal evolution of circadian activity waveform and thermosensitive timeless splicing

    Pragya Niraj Sharma, Vasu Sheeba
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
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Magazine

    1. Structural Biology and Molecular Biophysics

    Receptor Proteins: Lipids challenge ligands to control receptors

    Adam JM Wollman
    1. Medicine
    2. Structural Biology and Molecular Biophysics

    Medical Imaging: MRI sets its sights on collagen

    Fritz Schick
    1. Developmental Biology

    Limb Patterning: The cellular logic of limb regeneration

    Matthew Cherubino, Catherine D McCusker
    1. Neuroscience

    Aging: Linking neuron-glia interactions and longevity

    Michael Pokrass, Nan Hao

  5. Research Culture: Going beyond compliance to build on the Researcher Development Concordat

    Robert AR Drake, Laura A Gray ... Joan Chang
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Chromosomes: Finding a role for non-coding DNA in trypanosomes

    Markus R Schmidt
    1. Cancer Biology
    2. Cell Biology

    Chemotherapy: Lipid balance and chemoresistance in cancer cells

    Kaori Kanemaru, Yoshikazu Nakamura
  8. See more Magazine articles

Categories

  1. Biochemistry and Chemical Biology
  2. Cancer Biology
  3. Cell Biology
  4. Chromosomes and Gene Expression
  5. Computational and Systems Biology
  6. Developmental Biology
  7. Ecology
  8. Epidemiology and Global Health
  9. Evolutionary Biology
  10. Genetics and Genomics
  11. Immunology and Inflammation
  12. Medicine
  13. Microbiology and Infectious Disease
  14. Neuroscience
  15. Physics of Living Systems
  16. Plant Biology
  17. Stem Cells and Regenerative Medicine
  18. Structural Biology and Molecular Biophysics
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