Dysregulated exocytosis of bis(monoacylglycerol)phosphate (BMP)-enriched extracellular vesicles driven by pathogenic LRRK2 activity supports elevated urinary BMP levels and its use as a biomarker for Parkinson's disease.
Air pollution activates macrophage-derived artemin, sensitizing TRPA1 nociceptors to drive neutrophilic asthma, revealing new therapeutic targets for refractory airway inflammation.
Psilocin induces a durable neuroplastic state in human cortical neurons by enhancing BDNF signaling, neurite complexity, synaptogenesis, and synaptic network activity through 5-HT2A receptor-dependent mechanisms.
Independent experimental approaches demonstrate changes in TFAM binding to UVC-irradiated DNA, providing a potential mechanism for DNA damage sensing in the mitochondria.