Browse our Research Articles

Page 2 of 1,483
    1. Neuroscience

    Bilateral equalization of synaptic output in olfactory glomeruli of Xenopus tadpoles

    Marta Casas, Beatrice Terni, Artur Llobet
    A novel bilateral compensatory mechanism important for the activity of olfactory glomeruli in Xenopus tropicalis tadpoles was uncovered.
    1. Biochemistry and Chemical Biology

    The role of ATP synthase subunit e (ATP5I) in mediating the metabolic and antiproliferative effects of metformin in cancer cells

    Guillaume Lefrançois, Emilie Lavallée ... Gerardo Ferbeyre
    Biochemical and genetic evidence identifies ATP5I as a biguanide target, redefining biguanide action through ATP synthase regulation and assembly, mitochondrial architecture, and mitochondrial protein turnover.
    1. Neuroscience

    Drug-induced changes in connectivity to midbrain dopamine cells revealed by rabies monosynaptic tracing

    Katrina Bartas, Pieter Derdeyn ... Kevin T Beier
    Addictive drugs, as well as ketamine/xylazine, change the connectivity to ventral tegmental area dopamine cells, which may be related to cellular activity.
    1. Neuroscience

    Effort produces after-effects costly for others but valued for self

    Ya Zheng, Rumeng Tang
    Neural reward signals following effort are amplified for self-benefiting outcomes but attenuated for other-benefiting outcomes, contingent upon reward magnitude and individual effort sensitivity.
    1. Chromosomes and Gene Expression

    Identification of the regulatory elements and protein substrates of lysine acetoacetylation

    Qianyun Fu, Terry Nguyen ... Y George Zheng
    A newly developed chemo-immunological strategy enabled detection of acetoacetate-mediated lysine acetoacetylation, identified the associated regulatory enzymes, and revealed its distinct biological functions and physiological significance.
    1. Neuroscience

    A meta-analysis suggests that TMS targeting the hippocampal network selectively improves episodic memory

    Elena Badillo Goicoechea, Phillip F Agres ... Joel L Voss
    Meta-analysis indicates that network-targeted non-invasive brain stimulation consistently enhances memory function supported by the hippocampal network, thus providing robust evidence that specific memory abilities rely on specific modifiable brain networks.
    1. Neuroscience

    Subregional activity in the dentate gyrus is amplified during elevated cognitive demands

    Charlotte Castillon, Shintaro Otsuka ... Anis Contractor
    Selective engagement of suprapyramidal dentate gyrus neurons during a high-demand pattern separation task reveals blade-specific circuit engagement for enhancing mnemonic discrimination.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    The long non-coding RNA Dreg1 is required for optimal ILC2 development

    Sara Quon, Adelynn Tang ... Rhys Allan
    A Gata3 enhancer-embedded long non-coding RNA, Dreg1, was identified as being specifically required for optimal group 2 innate lymphoid cell development.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Physiological febrile heat stress increases cytoadhesion through increased protein trafficking of Plasmodium falciparum surface proteins into the red blood cell

    David Jones, Hugo Belda ... Moritz Treeck
    Fever, often seen as protective, accelerates protein export to surfaces of malaria-infected RBCs, increasing adhesion linked to disease severity.
    Version of Record
    Research Article
    • Important
    • Compelling
    • Convincing
    1. Developmental Biology

    Drosophila ryanodine receptor gene triggers functional and developmental muscle properties and could be used to assess the impact of human RYR1 mutations

    Monika Zmojdzian, Teresa Jagla ... Catherine Sarret
    The Drosophila ryanodine receptor plays a conserved role in setting functional and structural muscle properties, regulates embryonic muscle development and could be used to assess the impact of human RYR1 mutations.