Browse our Research Articles

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    1. Neuroscience

    Peripheral glia and neurons jointly regulate activity-induced synaptic remodeling at the Drosophila neuromuscular junction

    Yen-Ching Chang, Yi-Jheng Peng ... Karen T Chang
    Peripheral glia regulate synaptic remodeling at the Drosophila neuromuscular junction by balancing neuron-derived signals and controlling ambient glutamate levels, thereby revealing distinct glial mechanisms in activity-dependent synaptic plasticity.
    1. Neuroscience

    Functional characterization of neuropeptides that act as ligands for both calcitonin-type and pigment-dispersing factor-type receptors in a deuterostome

    Xiao Cong, Huachen Liu ... Muyan Chen
    Cell-line experiments and in vivo functional experiments provide the evidence that CT-type peptides can act as ligands for both CTR/CLR-type and PDF-type receptors in a deuterostome.
    1. Neuroscience

    Cholecystokinin modulates age-dependent thalamocortical neuroplasticity

    Xiao Li, Jingyu Feng ... Jufang He
    Cholecystokinin gates age-dependent auditory thalamocortical plasticity and, upon supplementation, reverses age-related plasticity decline and improves frequency discrimination.
    1. Neuroscience

    A stochastic RNA editing process targets a select number of sites in individual Drosophila glutamatergic motoneurons

    Andrés B Crane, Michiko O Inouye ... J Troy Littleton
    Patch-seq RNA profiling defines the overall RNA editing landscape and single neuron editing rules for individual genetically defined Drosophila larval motoneurons.
    1. Physics of Living Systems

    Emergent periodicity in the collective synchronous flashing of fireflies

    Raphael Sarfati, Kunaal Joshi ... Orit Peleg
    Fireflies that gather in swarms synchronize their flashing with rhythmic periodicity and provide insights into a new mechanism for the emergence of synchrony and periodicity.
    1. Structural Biology and Molecular Biophysics

    Conduction pathway for potassium through the Escherichia coli pump KdpFABC

    Adel Hussein, Xihui Zhang ... David L Stokes
    The path of potassium through an ATP-dependent membrane pump is elucidated with a high-resolution structure within a lipid bilayer together with mutational analysis at key points along this pathway.
    1. Microbiology and Infectious Disease

    The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2

    Rahul K Suryawanshi, Priyadarshini Jaishankar ... James S Fraser
    The development of new small molecules demonstrates how pharmacologic inhibition of the coronavirus macrodomain restores innate immunity, leading to reduced viral replication and improved outcomes in severe infection.
    1. Developmental Biology

    Comprehensive profiling of migratory primordial germ cells reveals niche-specific differences in non-canonical Wnt and Nodal-Lefty signaling in anterior vs posterior migrants

    Rebecca Garrett Jaszczak, Jay W Zussman ... Diana J Laird
    A temporal and positional atlas of mouse primordial germ cell (PGC) migration reveals dynamic gene expression and somatic cell interactions that suggest how changing migratory niches regulate PGC development.
    1. Biochemistry and Chemical Biology

    MCAK recognizes the nucleotide-dependent feature at growing microtubule ends

    Wei Chen, Yin-Long Song ... Xin Liang
    A key finding is that MCAK binds to the proximal region of GTP cap where GDP‧Pi-tubulins accumulate, in addition to curved protofilaments at the distalmost tip.
    1. Plant Biology

    Life-cycle-related gene expression patterns in the brown algae

    Pélagie Ratchinski, Olivier Godfroy ... J Mark Cock
    Life-cycle- and development-related patterns of gene expression are conserved in diverse brown algae.