Browse our Research Articles

Page 2 of 1,523
    1. Cell Biology

    Small brown planthopper infestation enhances it reproduction and insecticide tolerance by manipulating glucose distribution and levels in rice

    Hainan Zhang, Qi Zhang ... Jianjun Wang
    Small brown planthopper infestation drives rice glucose redistribution to boost its own reproduction and insecticide tolerance.
    1. Neuroscience

    The transcription factor BCL11A restores differentiation potential to aged oligodendrocyte progenitor cells

    Tanay Ghosh, Roey Baror ... Robin JM Franklin
    gSWITCH identifies dynamic lineage switch genes and reveals BCL11A as an evolutionarily conserved regulator whose restoration rescues age-impaired oligodendrocyte progenitor cell differentiation.
    1. Biochemistry and Chemical Biology

    SARS-CoV-2 main protease inhibition through dimerization promotion by peptidomimetic inhibitors and disruption by ebselen

    Chengxi Liu, Qinyu Jia ... Zhong-Ping Yao
    Distinct effects of peptidomimetic inhibitors and ebselen on SARS-CoV-2 main protease dimerization reveal new strategies for antiviral drug design.
    1. Structural Biology and Molecular Biophysics

    Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching

    Kexin Zhang, Timothy Grant, Nikolaus Grigorieff
    High-resolution structural information can be recovered from proteins well below the conventional cryo-electron microscopy size range, substantially extending the range of complexes accessible to structural analysis.
    1. Developmental Biology
    2. Neuroscience

    Heterogeneous responses to embryonic critical period perturbations within the Drosophila larval locomotor circuit

    Niklas Krick, Jacob J Davies ... Matthias Landgraf
    Within the locomotor network of the Drosophila embryo, connected elements, from premotor interneuron to muscle, respond differentially to a critical period perturbation, suggesting a sequence of adjustment.
    1. Medicine

    Mid-zone hepatocytes trade proliferation for survival via Atf4-Chop axis in early acute liver injury

    Yaying Zhu, Chengxiang Deng ... Zhao Shan
    Mid-zone hepatocytes transiently pause proliferation through the Atf4-Chop-Btg2 axis to prioritize survival over regeneration during early acute liver injury.
    1. Neuroscience

    Modulation of human dorsal root ganglion neuron excitability by Nav1.7 inhibition

    Akie Fujita, Sooyeon Jo ... Bruce P Bean
    Inhibition of Nav1.7 sodium channels in human dorsal root ganglion neurons had larger effects to reduce threshold and upstroke velocity of action potentials compared to Nav1.8 inhibition but smaller effects to reduce repetitive firing of action potentials.
    1. Microbiology and Infectious Disease

    Mycobacterium tuberculosis suppresses protective Th17 responses during infection

    Alex Zilinskas, Amir Balakhmet ... Sarah A Stanley
    Mycobacterium tuberculosis uses its type VII secretion system and surface lipid phthiocerol dimycocerosate to suppress protective host Th17 cell responses.
    1. Immunology and Inflammation

    An IL-21R STAT hypomorph circumvents functional redundancy in germinal centre responses

    Christoph Jandl, Joanna Warren ... Cecile King
    An IL-21 receptor mutation that differentially regulates STAT1 and STAT3 activation influenced the differentiation of T follicular cells.
    1. Neuroscience

    Large language models poorly capture how word order shapes representations of sentence meaning in the human brain

    James Fodor, Carsten Murawski, Shinsuke Suzuki
    Representations from models that explicitly encode semantic roles (who did what to whom) align better with activity in language regions of the brain than representations from transformers do.