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Stable allele-specific epigenetic regulation creates cellular mosaicism of numerous autosomal dosage-sensitive genes involved in human neurological and developmental disorders.

A comprehensive investigation of extracellular asparagine utilization highlights its role as a critical regulator of murine CD4+ T cell activation, differentiation, and function.

Working memory alternates between remembered items in a rhythmic theta cycle.

Deficiency in any of the interdependent C2a proteins (CCDC108, MYCBPAP, and CFAP70) collapses this central pair microtubule-associated projection, disrupting vertebrate ciliary movement, and causing primary ciliary dyskinesia phenotypes in mice.

Lenacapavir disrupts HIV-1 capsid elasticity, inducing mechanical rupture at the nuclear pore, highlighting that altering viral material properties can be a viable antiviral drug design strategy.

Two families of ubiquitin ligases secreted by the intracellular pathogen Legionella pneumophila utilize distinct chemistries to form a stable, ubiquitin-rich structure around the vacuole, which is subsequently disassembled as infection progresses.

Regulatory immune cells accumulate at the nose-to-brain interface during neuroinflammation, potentially dampening damaging immune responses.

Nickase and nuclease Prime Editors offer complementary routes for precise zebrafish genome editing, balancing accuracy for substitutions with efficiency for short insertions.

The brain uses separate prediction error and prediction uncertainty signals to trigger event boundaries.

Genes associated with male reproductive biology appear to be under relaxed selective constraint in a primate species with low sperm competition.