Christopher D Adam, Ehsan Mirzakhalili ... John A Wolf
Experimental TBI results in distinct patterns of network-level pathophysiology in the hippocampus that may contribute to TBI-associated cognitive deficits.
Nooshin Sheidaei, John K Eykelenboom ... Tomoyuki U Tanaka
An actomyosin network (PANEM) forms around the nucleus in prophase, and its contraction repositions peripheral and polar chromosomes to facilitate their interaction with the mitotic spindle, ensuring their correct segregation.
Katie H Long, Emily E Fitzgerald ... Charles M Greenspon
The breast, despite its importance in sexual and affective touch, exhibits poor tactile localization and demonstrates a relationship between size and innervation density.
Sophie Hall, Iara Aime Cardoso ... Christiane Schaffitzel
A generic strategy for producing functional snake venom metalloproteinases opens the field to reproducible mechanistic studies and inhibitor discovery.
Ourania Semelidou, Mathilde Tortochot-Megne Fotso ... Andreas A Frick
Altered tactile decision-making in autism reflects context-dependent weighting of sensory inputs and diminished integration of sensory history, enhancing low-salience discrimination while reducing category-based perceptual facilitation.
Evgeny Zatulovskiy, Magdalena B Murray ... Jan M Skotheim
Cellular sensitivity to cell death stimuli depends on cell-size-dependent proteome changes - specifically, cell size can modulate ferroptosis susceptibility through changes in glutathione biosynthetic enzymes, ferritin, and cathepsin B concentrations.
A comprehensive mutational scan of TYK2 identifies novel allosteric sites, elucidates functional drug-protein interactions, and links autoimmune disease protection to reduced TYK2 protein abundance.
Helge Feddersen, Charlotte Dyckmans, Marc Bramkamp
Dynamic relocalization of MinD in Bacillus subtilis arises from membrane binding of monomers and dimers with membrane-triggered ATP hydrolysis, suggesting MinE-like activators are unnecessary for Min system dynamics.
Arousal signals are present in the superior colliculus but appear to be organized in a way that they avoid directly triggering motor plans that lead to saccades.
