Browse our Research Articles

Page 2 of 1,521
    1. Genetics and Genomics
    2. Physiology

    RiboTRAP-seq identifies spatially distinct functions for the anterior and posterior intestine in immune and metabolic regulation in Caenorhabditis elegans

    Chung-Chih Liu, Nicolas Seban, Supriya Srinivasan
    Specialized anterior intestinal cells in Caenorhabditis elegans act as sentinels, regulating pathogen responses and linking food availability to gut peptide secretion through pyruvate metabolism.
    1. Neuroscience

    Individual dopaminergic neurons induce unique, yet overlapping combinations of behavioural modulations, including safety learning, memory retrieval, and acute locomotion

    Naoko Toshima, Arman Behrad ... Michael Schleyer
    Carrying 'teaching' signals and modulating movement, two highly conserved functions of the dopaminergic system across all animals, are brought about by the same individual dopaminergic neurons in an insect larva.
    1. Neuroscience

    Foveated metamers of the early visual system

    William Broderick, Gizem Rufo ... Eero Simoncelli
    Perceptual metamers reveal that the visual system averages luminance over a spatial extent four times smaller than spectral energy, but such estimates depend critically on experimental design choices.
    1. Plant Biology

    The petal identity gene PhDEF has a major binding and regulatory action in the epidermis

    Emma Désert, Quentin Cavallini-Speisser ... Marie Monniaux
    A petal identity factor mostly acts in the epidermis to regulate its target genes.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Intracellular growth of Chlamydia trachomatis leads to global histone hypermethylation by impairing demethylation

    Chloé I Charendoff, Félix V Louchez ... Agathe Subtil
    The metabolic pressure exerted by a pathogen with an intracellular lifestyle drives epigenetic modifications, which modulate the transcriptional response of the host to infection.
    1. Physics of Living Systems

    Salmonids elicit an acute behavioral response to heterothermal environments

    Robert Naudascher, Stefano Brizzolara ... Roman Stocker
    Juvenile brown trout rapidly respond to fine-scale temperature disturbances, demonstrating behavioral mechanisms that support resilience to sudden thermal disruptions in freshwater ecosystems.
    1. Neuroscience

    Reduced dorsal CA1 activity limits retention of the temporal component of declarative memory in the Cntnap2 knockout mouse model of autism

    Elise Caitlin Rawlinson, Michael Hugh McCullough ... Nathalie Dehorter
    Restoring hippocampal CA1 activation during temporal gaps is sufficient to rescue long-term memory in a mouse model of autism.
    1. Biochemistry and Chemical Biology

    Gluconeogenic compensation renders glycogen phosphorylase non-essential as an insecticidal target in Plutella xylostella

    Yifei Zhou, Yanqi Kang ... Jiyuan Liu
    Gluconeogenesis rescues insects from glycogen phosphorylase suppression, establishing metabolic redundancy as a key consideration for insecticide target selection.
    1. Cell Biology
    2. Immunology and Inflammation

    Allosteric disulfide control of ligand binding and endocytosis of KIR2DL4, the natural killer cell receptor for HLA-G

    Sumati Rajagopalan, Joyce Chiu ... Eric O Long
    Allosteric transition between two disulfide configurations of NK cell receptor KIR2DL4 is a functional switch that controls receptor residence at the cell surface for binding and internalization of soluble HLA-G.
    1. Cancer Biology

    JAK-STAT pathway heterogeneity governs immunotherapy response in breast cancer

    Jianbo Zhou, Heng Zhang ... Fu Peng
    Multi-omics investigation identifies cell-type JAK-STAT heterogeneity as a predictive biomarker for PD-1 blockade in breast cancer.