The viral type 2 internal ribosome entry site uses a unique mechanism to hijack the host ribosomal machinery by interacting with initiator tRNA and 40S head.
Whole-cell recordings paired with a network model show that post-inhibitory rebound excitation in premotor neurons couples intrinsic excitability to the temporal structure of learned birdsong.
A robust workflow for the identification of proline hydroxylation sites in proteins was established, using hydrophilic interaction chromatography enrichment and LC-MS/MS together with refining and filtering parameters during data analysis.
Proline hydroxylation of RepoMan (CDCA2) at P604 by PHD1 is shown to be important for mitotic progression and regulating interaction with PP2A regulatory subunit B56 gamma.
Rather than exerting a uniform influence, arousal modulates the connectome through a structured, low-dimensional community architecture characterized by discrete topological patterns and intrinsic hemispheric asymmetries.
Nevin K Zacharia, Stefanie Kuhns ... Esben Lorentzen
The IFT172 C-terminus bridges IFT-A and IFT-B complexes through mutually exclusive interactions with IFT140 and IFT144, and harbors a U-box-like domain linking intraflagellar transport to ubiquitin-dependent ciliary signaling.
Queuing theory links multiplicity of infection (MOI) to force of infection (FOI), enabling the estimation of transmission intensity for falciparum malaria (and other infectious diseases) from sparsely sampled surveys.