Browse our Research Articles

Page 2 of 1,477
    1. Developmental Biology
    2. Genetics and Genomics

    Single-cell co-mapping reveals relationship between chromatin state and gene expression in early zebrafish development

    Vivek Bhardwaj, Alberto Griffa ... Alexander van Oudenaarden
    A robust and quantitative map links chromatin modification and gene expression of cells during zebrafish embryogenesis.
    1. Neuroscience

    Modeling the hallucinatory effects of classical psychedelics in terms of replay-dependent plasticity mechanisms

    Colin Bredenberg, Fabrice Normandin ... Guillaume Lajoie
    Computational simulations indicate that classical psychedelics could induce hallucinations by co-opting neural circuitry dedicated to sleep-dependent replay and consolidation, providing a theoretical link between seemingly disparate fields of inquiry.
    1. Cell Biology

    Prior cocaine use disrupts identification of hidden states by single units and neural ensembles in orbitofrontal cortex

    Wenhui Zong, Lauren Mueller ... Geoffrey Schoenbaum
    Rats with a history of cocaine use exhibited prolonged encoding of idiosyncratic task features in orbitofrontal cortex and a reduced ability to compress such features to identify underlying hidden states.
    1. Microbiology and Infectious Disease

    Antibiotic potentiation and inhibition of cross-resistance in pathogens associated with cystic fibrosis

    Nikol Kadeřábková, R Christopher D Furniss ... Despoina AI Mavridou
    Targeting disulfide bond formation disables multiple antibiotic resistance mechanisms and prevents cross-protection between pathogens associated with cystic fibrosis lung infections, restoring antibiotic efficacy in polymicrobial settings.
    1. Neuroscience

    Alpha-band phase modulates perceptual sensitivity by changing internal noise and sensory tuning

    April Pilipenko, Alexandra McGowan, Jason Samaha
    Alpha-band, 8–13 Hz, neural oscillations phasically modulate the sensitivity of visual detection by changing internal sensory noise.
    1. Structural Biology and Molecular Biophysics

    Structural mechanisms of pump assembly and drug transport in the AcrAB–TolC efflux system

    Xiaofei Ge, Zhiwei Gu, Jiawei Wang
    High‑resolution cryo‑EM structures uncover YbjP as a novel lipoprotein that positions TolC and supports conformational changes in E. coli drug efflux pumps mediating antibiotic resistance.
    1. Neuroscience

    Dimorphic neural network architecture prioritizes sexual-related behaviors in male Caenorhabditis elegans

    Xuebin Wang, Hanzhang Liu ... He Liu
    Graph theory and computational modeling reveal that neural network architecture biases the male Caenorhabditis elegans brain toward prioritized sexual behaviors.
    1. Neuroscience

    How individual vigor shapes human–human physical interaction

    Dorian Verdel, Bastien Berret, Etienne Burdet
    Interactions between pairs of humans lead to the emergence of a dyadic vigor with similar characteristics as individual vigor, where both partners adapt, with the slower having a critical role.
    1. Developmental Biology

    Cdhr1a and pcdh15b may link photoreceptor outer segments with calyceal processes revealing a potential mechanism for cone-rod dystrophy

    Meet K Patel, Warlen Pereira Piedade, Jakub K Famulski
    Zebrafish cone photoreceptor outer segment integrity may be regulated by the interactions between the outer segments and calyceal processes mediated by retinal cadherins cdhr1a and pcdh15b.
    1. Cell Biology
    2. Medicine

    Uncovering shared and tissue-specific molecular adaptations to intermittent fasting in liver, brain, and muscle

    Yibo Fan, Senuri De Silva ... Thiruma V Arumugam
    A multi-tissue proteomic atlas uncovers the shared and distinct molecular signatures of metabolic flexibility induced by intermittent fasting.