Browse our Research Articles

Page 2 of 1,400
    1. Microbiology and Infectious Disease

    Unraveling CRP/cAMP-mediated metabolic regulation in Escherichia coli persister cells

    Han G Ngo, Sayed Golam Mohiuddin ... Mehmet Orman
    CRP/cAMP plays a crucial role in the metabolic shift of Escherichia coli persisters from an anabolic state to oxidative phosphorylation, which is essential for their survival during antibiotic treatment.
    1. Cell Biology

    Quantitative intra-Golgi transport and organization data suggest the stable compartment nature of the Golgi

    Hieng Chiong Tie, Haiyun Wang ... Lei Lu
    Quantitative measurements of intra-Golgi transport kinetics of diverse secretory cargos challenge the classic cisternal progression model and support the stable compartment model of the Golgi.
    1. Cell Biology

    Forward genetics in C. elegans reveals genetic adaptations to polyunsaturated fatty acid deficiency

    Delaney Kaper, Uroš Radović ... Marc Pilon
    Polyunsaturated fatty acids are not genetically replaceable in the nematode C. elegans and only mutations that help free ferrous ions can boost the activity of a poorly functioning desaturase enzyme.
    1. Immunology and Inflammation

    β-Glucan reprograms alveolar macrophages via neutrophil/IFNγ axis in a murine model of lung injury

    Renaud Prevel, Erwan Pernet ... Maziar Divangahi
    β-Glucan-mediated trained immunity activates alveolar macrophages which exacerbates acute lung injury induced by LPS.
    1. Microbiology and Infectious Disease

    Function and firing of the Streptomyces coelicolor contractile injection system requires the membrane protein CisA

    Bastien Casu, Joseph W Sallmen ... Susan Schlimpert
    CryoEM, genetic, and cell biological analyses reveal that the conserved membrane protein CisA mediates membrane recruitment of contractile injection systems Streptomyces coelicolor, enabling their activation under stress.
    1. Computational and Systems Biology
    2. Neuroscience

    Homophilic wiring principles underpin neuronal network topology in vitro

    Danyal Akarca, Alexander WE Dunn ... Manuel Schröter
    1. Evolutionary Biology

    Diverse prey capture strategies in teleost larvae

    Duncan S Mearns, Sydney A Hunt ... Herwig Baier
    The evolution of hunting behavior in fish larvae has arrived at different, species-specific solutions, recombining a shared repertoire of locomotor and eye movement motifs.
    1. Structural Biology and Molecular Biophysics

    The C-terminus of the multi-drug efflux pump EmrE prevents proton leak by gating transport

    Merissa Brousseau, Da Teng ... Katherine A Henzler-Wildman
    The C-terminal tail acts as a secondary gate to regulate substrate access into the primary binding site for transport across the membrane.
    1. Cell Biology
    2. Medicine

    The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence

    Fan Zhang, Yuan Wang ... Xianpeng Ge
    CHMP5 is crucial in preventing skeletal progenitor cell senescence and abnormal bone formation, and senolytic drugs represent potential therapeutic medicine for musculoskeletal abnormalities associated with a dysfunctional endolysosomal pathway.