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Bacterial therapy can be impeded by nutrition deprivation in the tumor microenvironment, and enhancing bacteria resistance to iron sequestration enhances its antitumoral activity for therapeutic purposes.

A comprehensive allosteric model describes how inhibitors can activate rather than inhibit a target kinase by selectively driving formation of kinase dimers with one inhibited and one activated subunit.

Disruption of the Clock gene in the cnidarian Nematostella vectensis revealed its essential role in circadian rhythm maintenance and uncovered a compensatory light-response pathway, advancing our comprehension of circadian regulation in non-bilaterian animals.

In reporter mice, subtypes of peripheral neurons show different regenerative capabilities after nerve injury and activate common pathways but also specific ones, indicating a different intrinsic growth response among them.

Drosophila model reveals that NTE/SWS-associated neurodegeneration is a lysosomal storage disorder accompanied by a leaky brain permeability barrier, abnormal fatty acid metabolism, and inflammation.

In a stress-specific manner, Mycobacterium tuberculosis PhoP regulates Rv0805 phosphodiesterase expression to control cAMP level and contributes to intracellular survival of the bacilli.

A virtual balancing task with parallel experiments on human and non-human primates revealed a spectrum of behaviors (classified by a computational model into position, velocity, or mixed control strategy) that can serve as basis for analyzing neural population dynamics.

Overexpression of inhibitor of Bruton's tyrosine kinase contributes to the process of tumorigenesis by amplifying translation, represents a promising target for anti-cancer therapies.

Equivalence testing and Bayes factors are informative statistical methods for analyzing replication studies of original studies with null results, and can address the limitations of the commonly used non-significance criterion.