Browse our Research Articles

Clinically relevant Ω-loop mutations in PDC-3 reshape active-site dynamics to enhance β-lactamase activity, providing mechanistic insights that can guide the rational design of inhibitors.

ATAD2 orchestrates histone turnover during spermatogenesis, regulating H3.3 deposition, chromatin condensation, and genome packaging to ensure proper sperm genome organization and transcriptional control.

CD47^Hi synovial mesenchymal stem cells are identified as a functionally distinct sub-population that regenerates articular cartilage and reduces osteoarthritis severity in a preclinical joint injury model.

Single-cell transcriptomics identifies three discrete mouse trabecular meshwork subtypes and demonstrates that an Lmx1b glaucoma mutation drives mitochondrial dysfunction and elevated intraocular pressure, which is lessened by vitamin B3 supplementation.

Encoding individual behavioral traits into a low-dimensional latent representation enables the accurate prediction of decision-making patterns across distinct task conditions.

GMCL1-dependent degradation of 53BP1 suppresses mitotic surveillance, tuning p53 activation thresholds that govern cell fate decisions and cellular responses after mitosis.

Formation and stability of endocytic receptor-arrestin complexes during clathrin-mediated endocytosis are governed by phosphorylation-dependent arrestin-AP2 interactions.

Targeted computational redesign of an IL-7 superkine with enhanced folding efficiency and receptor affinity demonstrates superior immune-stimulatory and antitumor activity over wild-type IL-7.

The glial-specific role of betaPix during cerebral blood vessel development has been revealed by establishing a new betaPix conditional trap allele in zebrafish.

Distinct patterns of SARS-CoV-2 viral dynamics in saliva reveal heterogeneity that cannot be sufficiently explained by conventional clinical characteristics or microRNA profiles alone.