Browse our Research Articles

Page 2 of 1,497
    1. Neuroscience

    How attention simplifies mental representations for planning

    Jason da Silva Castanheira, Christina Chang He ... Stephen M Fleming
    Spatial attention controls the information people become aware of and, in turn, incorporate into simplified perceptual representations for use in multi-step planning.
    1. Neuroscience

    Kinematic signatures in reaching movements during spaceflight provide evidence that humans underestimate body mass in microgravity

    Zhaoran Zhang, Yu Tian ... Kunlin Wei
    Model-based kinematic analyses link the movement slowing in spaceflight to body mass underestimation.
    1. Microbiology and Infectious Disease

    The targeted cytosolic degradation of class I histone deacetylases is essential for efficient alphaherpesvirus replication

    Sheng-Li Ming, Meng-Hua Du ... Bei-Bei Chu
    Alphaherpesviruses hijack host epigenetic regulation by promoting HDAC1/2 nuclear export and degradation to activate the DNA damage response, revealing new antiviral therapeutic targets.
    1. Computational and Systems Biology
    2. Neuroscience

    Comparing the outputs of intramural and extramural grants funded by National Institutes of Health

    Xiang Zheng, Qiyao Yang ... B Ian Hutchins
    Funding mechanisms impact the cost effectiveness of the science conducted, as extramural NIH grants to universities excel at producing papers and citations, while intramural NIH hiring more effectively translates to clinical impact.
    1. Developmental Biology
    2. Neuroscience

    The microtubule-binding protein EML3 is required for mammalian embryonic growth and cerebral cortical development, and Eml3 null mice are a model of cobblestone brain malformation

    Isabelle Carrier, Eduardo Diez ... Roderick McInnes
    Absence of EML3 in mice leads to delayed embryonic development, small size, perinatal lethality, and the over-migration of neuroblasts due to a defective pial basement membrane.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Canonical and phosphoribosyl ubiquitination coordinate to stabilize a proteinaceous structure surrounding the Legionella-containing vacuole

    Adriana Steinbach, Chetan Mokkapati ... Shaeri Mukherjee
    Two families of ubiquitin ligases secreted by the intracellular pathogen Legionella pneumophila utilize distinct chemistries to form a stable, ubiquitin-rich structure around the vacuole, which is subsequently disassembled as infection progresses.
    1. Structural Biology and Molecular Biophysics

    Lenacapavir-induced lattice hyperstabilization is central to HIV-1 capsid failure at the nuclear pore complex and in the cytoplasm

    Arpa Hudait, Ryan C Burdick ... Gregory A Voth
    Lenacapavir disrupts HIV-1 capsid elasticity, inducing mechanical rupture at the nuclear pore, highlighting that altering viral material properties can be a viable antiviral drug design strategy.
    1. Neuroscience

    Visual working memory guides attention rhythmically in humans

    Jiachen Lu, Yaochun Cai, Xilin Zhang
    Working memory alternates between remembered items in a rhythmic theta cycle.
    1. Neuroscience

    Medial prefrontal cortex encodes but is not required to generate goal-directed actions under threat

    Muhammad S Sajid, Ji Zhou, Manuel A Castro-Alamancos
    Medial prefrontal cortex activity is not required for learning or execution of adaptive avoidance behavior, despite encoding select task features.
    1. Cell Biology

    Proteomic composition and mutual assembly of the C2a projection in vertebrate motile cilia

    Qian Lyu, Qingchao Li ... Huijie Zhao
    Deficiency in any of the interdependent C2a proteins (CCDC108, MYCBPAP, and CFAP70) collapses this central pair microtubule-associated projection, disrupting vertebrate ciliary movement, and causing primary ciliary dyskinesia phenotypes in mice.