OCRL deficiency is associated with mitochondrial dysfunction, altered ciliary signaling, and disrupted neural cell-state regulation across multiple experimental models of Lowe syndrome.
Inhibiting the mitochondrial bc1-complex disrupts energy production in mature Toxoplasma gondii bradyzoites, suggesting a metabolic vulnerability in the parasite's chronic, drug-resistant stage.
A comprehensive two-hybrid map of the Set1C interactome broadens understanding of Set1C subunit functions and identifies a novel link between Set1C and arginine methylation.
The perceived value of task outcomes, rather than task aversiveness, predicts reduced everyday procrastination following transcranial direct current stimulation, and offers a potential target for behavioral intervention.
Daniel Haertter, Lara Hauke ... Christoph F Schmidt
A non-monotonic force–velocity relationship in cardiac sarcomeres causes dynamic instability, leading to stochastic heterogeneity in contracting cardiomyocytes, which can have a protective function.