Browse our Research Articles

Structural and biochemical analyses identify a bacterial lipoprotein that associates with the outer membrane component of tripartite multi-drug efflux pumps, and its potential functional roles are explored by complementary bioinformatics, proteomcid and genetic approaches.

Single-cell analysis fails to find a functional link between the organization of chromatin domain organization and gene activity.

Comparing signaling response profiles and fate outcomes in single cells reveals logic and limits of signal interpretation.

Placenta-binding parasites show that chromatin-based mechanisms regulate placental malaria virulence gene, var2csa, and requires loss of H3K9me3-mediated heterochromatic silencing and 3D nuclear repositioning away from telomeric-repressive clusters.

Stress-recruited neurons can cause anxiety-like avoidance and increase peripheral corticosterone concentration.

Geometric confinement paradoxically enhances bacterial chemotaxis through chiral surface swimming and sidewall alignment, with optimal performance when lane width matches the circular swimming radius.

Olfactory fear conditioning biases olfactory stem cell receptor fate, increasing the frequency by which maturing neurons express the receptor of the paired odor and changing the representation of the olfactory sensory neuron landscape in the next generation.

Cargo-adaptor binding to the KLC-TPR domains binding triggers structural rearrangements that relieve kinesin-1 autoinhibition, enabling MAP7 recruitment, through an allosteric mechanism that connects cargo recognition to motor activation.

Synaptotagmin 1 and Synaptotagmin 7 promote MAIT cell activation during Mycobacterium tuberculosis infection by facilitating MR1 trafficking and antigen presentation.

Membrane composition modulates EGFR conformational dynamics and signaling, revealing that the bilayer properties can override ligand control to influence receptor activation in health and disease.