Squidly enables efficient identification of enzyme catalytic residues by integrating functional hierarchies into a contrastive learning framework, requiring only protein sequences to produce scalable predictions across the known enzyme landscape.
Jenny A Hurcombe, Lusyan Dayalan ... Richard JM Coward
Simultaneously knocking down both the insulin and IGF1 receptor in the kidney podocyte is highly detrimental, affecting spliceosome function and gene transcription.
Computational modeling and human pilot study present a mechanistic framework explaining the capacity for transcutaneous tibial nerve stimulation to induce excitatory or inhibitory effects based on electrical stimulation frequency alone.
Zahra Seraj, Ximena Zottig ... Andrei A Korostelev
Cryogenic electron microscopy of cellular extracts can visualize atomic details and discover new interactions between biological molecules, such as the interactions of the ribosome, the protein-making machinery, with essential proteins to regulate cellular functions.
Vocalizations of nonhuman primates, especially when acoustic and phylogenetic proximity is the highest, enhance human brain activity in the anterior temporal lobe.
Tommy Clausner, José P Marques ... Mathilde Bonnefond
Combined human laminar EEG–fMRI reveals feature-specific gamma band activity, and dissociates general (lower frequency) from feature-specific (higher frequency) alpha band activity related to superficial and deep cortical layers.
The tuft dendrites of neurons in the premotor cortex are uniquely selective for corrective actions, suggesting a specialized role in motor control and motor learning.
