Browse our Research Articles

Disease-associated mutations in BICD2 result in loss- and gain-of-function interactions and dynein hyperactivity.

Eed, a core subunit of Polycomb repressive complex 2, is required for craniofacial osteoblast differentiation and mesenchymal proliferation after induction of the neural crest.

Molecular and morphological profiles of developing neurons in vitro uncover the cellular dynamics of human neurodevelopment and related disease.

A pharmacogenetic approach provides a foundational dataset describing the influence of opioids on synaptic processing in a brain microcircuit known to be critical for driving hedonic behaviors.

In vitro reconstitution identifies how lysosome-related vacuoles coordinate the synthesis and turnover of inorganic polyphosphates to create a powerful buffer system stabilising a vital metabolic parameter, the cytosolic concentration of phosphate.

The demonstration of effort discounting-like behavior in a lower invertebrate sets a new phylogenetic boundary on discounting behavior.

By providing new ways to map cortico-subcortical connectivity patterns, the proposed cross-species tractography approaches directly allow novel comparative studies between the human and macaque brain and enable subsequent explorations of brain-behaviour/disease symptom associations across individuals.

Calcium levels and structural diversity among synaptic ribbons in bipolar neurons likely enable differential encoding of visual information, revealing a potential mechanism for fine-tuning sensory signal processing.

Purkinje cell subpopulations have varying vulnerability to age-related neurodegeneration, creating a striped pattern of cell loss that reflects the developmental, anatomical, and functional organization of the cerebellum.

A normative computational model of individual differences in mouse exploration driven by reward and threat uncertainty as well as risk sensitivity when faced with a novel object in an open field.