Disrupting oligodendrocytes during a narrow early-life window leaves cerebellar circuits permanently mistimed, but adult re-synchronization restores social and motor behavior.
Katrina M Zinn, Mathew W McLaren ... Matthew J Elrick
Enterovirus D68, a cause of acute flaccid myelitis, disrupts the composition and function of the nuclear pore complex primarily through its 2A protease, which is also toxic to motor neurons.
A multi-step ribosome assembly method involving changes in ion concentration and temperature can now be carried out in a single step using the two GTPase factors, EngA and ObgE.
Tom Louis Ducrocq, Damien Laporte, Bertrand Daignan-Fornier
A genetic analysis in yeast establishes that multicellularity can arise as a side-effect (passenger phenotype) of a completely independent fitness advantage unrelated to the benefits of group formation itself.
Terminal tracheal cells in Drosophila evade innate immune activation, revealing a fundamental trade-off in which suppression of canonical immune signaling preserves Foxo-dependent plasticity and sustains respiratory function.
Javier Emperador-Melero, Steven J Del Signore ... Avital A Rodal
Presynaptic endocytic machinery is constitutively deployed to periactive zones, indicating independent assembly pathways for the exo- and endocytic machineries of nerve terminals.
Kathleen S Metz Reed, Andrew Fritz ... Tom Misteli
Genome-wide maps of chromatin structure in a cell-based model of breast cancer reveal chromatin reorganization accompanied by changes in transcription and epigenetic marks.
Analyses of two independent phylogenomic datasets suggest an explosive radiation at the origin of Spiralia, with implications for understanding the group's evolutionary history.
