Sofia Lövestam, Jane L Wagstaff ... Sjors HW Scheres
Phosphomimetic mutations allow the assembly of full-length recombinant tau into Alzheimer's paired helical filaments by disrupting intramolecular contacts between its ordered core and fuzzy coat.
EXOC6A cooperates with myosin-Va to regulate vesicle trafficking and membrane remodeling during ciliogenesis, enabling ciliary vesicle maturation, transition zone assembly, and proper delivery of ciliary membrane proteins.
Ophélie J Gosselin, Michael Taschner ... Stephan Gruber
A screen using in vitro-selected synthetic nanobodies identified inhibitors of SMC protein function in bacterial cells, revealing a coiled coil region as a vital component of the chromosome-folding machinery.
Sourav Banerjee, Nicola Minshall ... Mark Carrington
The glycosylphosphatidylinositol (GPI)-anchored receptors in Trypanosoma brucei are not confined to the flagellar pocket but instead localise across the whole cell surface, reshaping our understanding of host immune evasion and nutrient uptake.
William Salvidge, Chris Brimson ... Chris Thompson
Experiments and mathematical modelling show cell fate in Dictyostelium discoideum partly depends on cell-cycle phase, but also on stochastic gene-expression variability which enhances robustness of developmental responses to cell-cycle perturbation.
Functional and mechanistic analyses reveal that intranasal decoys engage phagocytic clearance beyond viral neutralization to provide effective protection, establishing immune redirection for developing broad-spectrum countermeasures against airborne viral threats.