Browse our Research Articles

Page 2 of 1,440
    1. Neuroscience

    Complex opioid-driven modulation of glutamatergic and cholinergic neurotransmission in a GABAergic brain nucleus associated with emotion, reward, and addiction

    Ramesh Chittajallu, Anna Vlachos ... Chris J McBain
    A pharmacogenetic approach provides a foundational dataset describing the influence of opioids on synaptic processing in a brain microcircuit known to be critical for driving hedonic behaviors.
    1. Neuroscience

    Cross-species standardised cortico-subcortical tractography

    Stephania Assimopoulos, Shaun Warrington ... Stamatios N Sotiropoulos
    By providing new ways to map cortico-subcortical connectivity patterns, the proposed cross-species tractography approaches directly allow novel comparative studies between the human and macaque brain and enable subsequent explorations of brain-behaviour/disease symptom associations across individuals.
    1. Neuroscience

    Individual differences in tail risk sensitive exploration using Bayes-adaptive Markov decision processes

    Tingke Shen, Peter Dayan
    A normative computational model of individual differences in mouse exploration driven by reward and threat uncertainty as well as risk sensitivity when faced with a novel object in an open field.
    1. Neuroscience

    Center-surround inhibition in expectation and its underlying computational and artificial neural network models

    Ling Huang, Shiqi Shen ... Xilin Zhang
    Expectation optimizes perception through center-surround inhibition, enhancing expected representations while suppressing similar, irrelevant ones.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    The Shigella flexneri effector IpaH1.4 facilitates RNF213 degradation and protects cytosolic bacteria against interferon-induced ubiquitylation

    Luz Saavedra-Sanchez, Mary S Dickinson ... Jorn Coers
    The enteric bacterial Shigella secretes a virulence factor that degrades the pivotal human defense protein RNF213, thereby protecting cytosolic bacteria from interferon-driven ubiquitylation and associated innate immunity.
    1. Cancer Biology
    2. Cell Biology

    Human RAP2A homolog of the Drosophila asymmetric cell division regulator Rap2l targets the stemness of glioblastoma stem cells

    Maribel Franco, Ricardo Gargini ... Ana Carmena
    Restitution of RAP2A, human homolog of Drosophila asymmetric cell division regulator Rap2l, in glioblastoma neurosphere cultures targets the stemness of glioblastoma stem cells and could contribute to reduce glioblastoma expansion.
    1. Neuroscience

    Prosapip1 (encoded by the Lzts3 gene) in the dorsal hippocampus mediates synaptic protein composition, long-term potentiation, and spatial memory

    Zachary W Hoisington, Himanshu Gangal ... Dorit Ron
    Novel function of Prosapip1, a scaffolding protein highly expressed in the hippocampus, in maintaining postsynaptic density integrity and plays a vital role in synaptic plasticity, learning, and memory.
    1. Cell Biology

    The RAB27A effector SYTL5 regulates mitophagy and mitochondrial metabolism

    Ana Lapão, Lauren Sophie Johnson ... Anne Simonsen
    RAB27A-dependent mitochondrial recruitment of SYTL5 promotes mitophagy and mitochondrial bioenergetics upon hypoxia.
    1. Cell Biology

    Specific proteolysis mediated by a p97-directed proteolysis-targeting chimera (PROTAC)

    Constanza Salinas-Rebolledo, Javier Blesa ... Alejandro Rojas-Fernandez
    1. Genetics and Genomics
    2. Neuroscience

    Avoidance of hydrogen sulfide is modulated by external and internal states in Caenorhabditis elegans

    Longjun Pu, Lina Zhao ... Changchun Chen
    Mitochondrial remodeling, ROS-dependent signaling, and diverse environmental and physiological cues underlie the initiation and persistence of locomotory activity of C. elegans in toxic H2S.