Browse our Research Articles

Page 2 of 1,445
    1. Neuroscience

    Strikingly different neurotransmitter release strategies in dopaminergic subclasses

    Ana Dorrego-Rivas, Darren J Byrne ... Matthew S Grubb
    Different locations of neurotransmitter release sites in axon-bearing and anaxonic olfactory bulb dopaminergic neurons allow self-inhibition only in anaxonic cells, showing how polarity differences create separate functional roles in sensory processing.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Lifestyles shape genome size and gene content in fungal pathogens

    Anna Fijarczyk, Pauline Hessenauer ... Christian R Landry
    A genomic analysis shows that the evolution of genome size and gene content among fungal pathogens in the class Sordariomycetes varies depending on their interactions with hosts and vectors.
    1. Physics of Living Systems

    Postural adaptations may contribute to the unique locomotor energetics seen in hopping kangaroos

    Lauren Thornton, Taylor Dick ... Christofer J Clemente
    Postural adjustments that reduce ankle leverage in kangaroos enhance tendon stress and elastic energy storage at higher speeds, providing energetic efficiency during hopping but potentially constraining the maximum size achievable by large species.
    1. Immunology and Inflammation

    Immunoglobulin M regulates airway hyperresponsiveness independent of T helper 2 allergic inflammation

    Sabelo Hadebe, Anca Flavia Savulescu ... Frank Brombacher
    Immunoglobulin M has other functions beyond antibody class switching that have implications in asthma treatment.
    1. Neuroscience

    Dissociable memory modulation mechanisms facilitate fear amnesia at different timescales

    Yinmei Ni, Ye Wang ... Jian Li
    The retrieval-extinction paradigm elicits a short-term fear amnesia that differs in cue specificity, timescale, and dependence on thought-control ability from the long-term amnesia believed to be associated with memory reconsolidation.
    1. Immunology and Inflammation
    2. Stem Cells and Regenerative Medicine

    IL-27 limits HSPC differentiation during infection and protects from stem cell exhaustion

    Daniel L Aldridge, Zachary Lanzar ... Christopher A Hunter
    Functional analyses showcase that in the absence of IL-27, hematopoietic stem and progenitor cells are more likely to become monocytes during toxoplasmosis, making them less responsive after infection.
    1. Genetics and Genomics

    Chromatin accessibility variation provides insights into missing regulation underlying immune-mediated diseases

    Raehoon Jeong, Martha L Bulyk
    Analyzing population-level chromatin accessibility data shows added benefit over utilizing only gene expression data in elucidating the genetic mechanism of disease-associated variants.
    1. Neuroscience

    Early changes in the properties of CA3 engram cells explored with a novel viral tool in mice

    Dario Cupolillo, Noelle Grosjean ... Christophe Mulle
    A novel viral tool (FLEN) is designed, and used to monitor changes in the intrinsic and synaptic properties of engram cells quickly (3–6 hours) following encoding of a memory.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Degradation of LMO2 in T cell leukaemia results in collateral breakdown of transcription complex partners and causes LMO2-dependent apoptosis

    Naphannop Sereesongsaeng, Carole Bataille ... Terence Rabbitts
    Antibody surrogate degraders of LMO2 indicate that transcription complexes are susceptible to drug discovery and are therefore druggable.
    1. Neuroscience

    Separating the control of moving and holding in human post-stroke arm paresis

    Alkis M Hadjiosif, Kahori Kita ... John W Krakauer
    Patients with stroke often show impairment in both moving and holding the arm, deficits that are dissociable experimentally, suggesting that moving and holding are controlled by separate neural mechanisms.