Browse our Research Articles

Page 2 of 1,477
    1. Developmental Biology
    2. Immunology and Inflammation

    HEB collaborates with TCR signaling to upregulate Id3 and enable γδT17 cell maturation in the fetal thymus

    Johanna S Selvaratnam, Juliana DB da Rocha ... Michele Kay Anderson
    Dynamic regulation of the E-protein/Id axis links TCR signaling to the maturation of IL-17-producing γδ T cells.
    1. Cell Biology
    2. Immunology and Inflammation

    Clathrin-independent endocytosis and retrograde transport in cancer cells tune immune synapse organization and CD8 T cell response

    Shiqiang Xu, Alix Buridant ... Henri-François Renard
    Endophilin-A3-mediated clathrin-independent endocytosis and retrograde trafficking in cancer cells regulate ICAM1 organization at the immune synapse and influence cytotoxic CD8 T cell response.
    1. Physics of Living Systems

    Colony demographics shape nest construction in Camponotus fellah ants

    Harikrishnan Rajendran, Roi Weinberger ... Ofer Feinerman
    The architecture of an ant nest serves as a fossilized record of the colony's demographic history, with distinct growth patterns and catastrophic events through age-specific digging behaviors.
    1. Developmental Biology
    2. Genetics and Genomics

    Single-cell co-mapping reveals relationship between chromatin state and gene expression in early zebrafish development

    Vivek Bhardwaj, Alberto Griffa ... Alexander van Oudenaarden
    A robust and quantitative map links chromatin modification and gene expression of cells during zebrafish embryogenesis.
    1. Neuroscience

    Modeling the hallucinatory effects of classical psychedelics in terms of replay-dependent plasticity mechanisms

    Colin Bredenberg, Fabrice Normandin ... Guillaume Lajoie
    Computational simulations indicate that classical psychedelics could induce hallucinations by co-opting neural circuitry dedicated to sleep-dependent replay and consolidation, providing a theoretical link between seemingly disparate fields of inquiry.
    1. Microbiology and Infectious Disease

    Antibiotic potentiation and inhibition of cross-resistance in pathogens associated with cystic fibrosis

    Nikol Kadeřábková, R Christopher D Furniss ... Despoina AI Mavridou
    Targeting disulfide bond formation disables multiple antibiotic resistance mechanisms and prevents cross-protection between pathogens associated with cystic fibrosis lung infections, restoring antibiotic efficacy in polymicrobial settings.
    1. Neuroscience

    Brain-wide mapping of layer-specific functional connectivity in the human cortex at 3T using draining-vein-suppressed fMRI

    Wei-Tang Chang, Weili Lin, Kelly S Giovanello
    A velocity-nulled 3T GE-EPI fMRI method enabling 0.9-mm whole-brain imaging that suppresses vascular contamination and reliably maps layer-specific functional connectivity in human cortex.
    1. Cell Biology

    Prior cocaine use disrupts identification of hidden states by single units and neural ensembles in orbitofrontal cortex

    Wenhui Zong, Lauren Mueller ... Geoffrey Schoenbaum
    Rats with a history of cocaine use exhibited prolonged encoding of idiosyncratic task features in orbitofrontal cortex and a reduced ability to compress such features to identify underlying hidden states.
    1. Cell Biology

    Orderly mitosis shapes interphase genome architecture

    Krishnendu Guin, Adib Keikhosravi ... Tom Misteli
    High-throughput CRISPR-KO imaging screens reveal that disruption of mitotic processes impairs spatial genome organization in daughter cells.
    1. Neuroscience

    Dimorphic neural network architecture prioritizes sexual-related behaviors in male Caenorhabditis elegans

    Xuebin Wang, Hanzhang Liu ... He Liu
    Graph theory and computational modeling reveal that neural network architecture biases the male Caenorhabditis elegans brain toward prioritized sexual behaviors.