In an assay focusing on active virus recruitment rather than passive binding, STED microscopy reveals early association of virions to CD151, indicating its early involvement in viral entry platforms formation.
Analyses of two independent phylogenomic datasets suggest an explosive radiation at the origin of Spiralia, with implications for understanding the group's evolutionary history.
Iman Hamid, Ólavur Mortensen ... Noomi O Gregersen
Present-day Faroese genomes reveal ancestry, bottleneck history, and signatures of selection, and offer a foundation for understanding the genetic architecture of health and disease in this North Atlantic founder population.
Fidel Emmanuel Serrano, Daniela Marzoll ... Michael Brunner
Repressive PER2:CRY1:CK1δ complexes assembling in the cytosol enter the nucleus, where PER2 hyperphosphorylation eventually disrupts the complex, causing PER2 to relocalize to the cytoplasm, allowing nuclear accumulation of CRY1.
Ariunaa Bayanjargal, Cenny Taslim ... Emily Rose Theisen
A discrete helix in the fusion oncoprotein DNA binding domain shifts binding preferences toward long and dense GGAA repeats, which promotes transcriptional hub formation and drives EWSR1::FLI1-mediated gene regulation.
Christopher D Adam, Ehsan Mirzakhalili ... John A Wolf
Experimental TBI results in distinct patterns of network-level pathophysiology in the hippocampus that may contribute to TBI-associated cognitive deficits.
Nooshin Sheidaei, John K Eykelenboom ... Tomoyuki U Tanaka
An actomyosin network (PANEM) forms around the nucleus in prophase, and its contraction repositions peripheral and polar chromosomes to facilitate their interaction with the mitotic spindle, ensuring their correct segregation.
Katie H Long, Emily E Fitzgerald ... Charles M Greenspon
The breast, despite its importance in sexual and affective touch, exhibits poor tactile localization and demonstrates a relationship between size and innervation density.
