Browse our latest Evolutionary Biology articles

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    1. Cancer Biology
    2. Evolutionary Biology

    Cancer–immune coevolution dictated by antigenic mutation accumulation

    Long Wang, Christo Morison, Weini Huang
    Genetic information in cancer cells reveals the strength of cancer–immune interactions in an individual-based stochastic model, which captures explicit interactions between cancer and effector cells.
    1. Immunology and Inflammation
    2. Evolutionary Biology

    Evolutionary Adaptations of IRG1 Refines Itaconate Synthesis and Mitigates Innate Immunometabolism Trade-offs

    Richard V Szeligowski, Francois Miros ... Hongying Shen
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Evolutionary Biology

    Sending mixed signals: convergent iridescence and divergent chemical signals in sympatric sister-species of Amazonian butterflies

    Joséphine Ledamoisel, Bruno Buatois ... Violaine Llaurens
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Cancer Biology
    2. Evolutionary Biology

    Punctuated mutagenesis promotes multi-step evolutionary adaptation in human cancers

    Christopher Graser, Wenbo Wu ... Franziska Michor
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Evolutionary Biology

    Viral genome sequence datasets display pervasive evidence of strand-specific substitution biases that are best described using non-reversible nucleotide substitution models

    Rita Sianga-Mete, Penelope Hartnady ... Darren P Martin
    Non-reversible nucleotide substitution models best describe strand-specific nucleotide substitution biases of viral genomes.
    1. Evolutionary Biology
    2. Physics of Living Systems

    Adaptations in wing morphology rather than wingbeat kinematics enable flight in small hoverfly species

    Camille Le Roy, Nina Tervelde ... Florian T Muijres
    Small hoverflies compensate for size-related flight challenges through evolutionary changes in wing shape rather than altered wingbeat kinematics.
    1. Evolutionary Biology

    Heterozygote advantage cannot explain MHC diversity, but MHC diversity can explain heterozygote advantage

    Joshua L Cherry
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Importance of higher-order epistasis in protein sequence-function relationships

    Palash Sethi, Juannan Zhou
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Evolutionary Biology

    Forecasting protein evolution by integrating birth-death population models with structurally constrained substitution models

    David Ferreiro, Luis Daniel González-Vázquez ... Miguel Arenas
    Forecasting protein evolution in terms of folding stability using state-of-the-art population genetics and substitution models is feasible in rugged fitness landscapes, whereas forecasting exact amino acid sequences remains more challenging.
    1. Evolutionary Biology

    Parallel HIV-1 fitness landscapes shape viral dynamics in humans and macaques that develop broadly neutralizing antibodies

    Kai S Shimagaki, Rebecca M Lynch, John P Barton
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
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