Clinical, genetic, and model organism data collectively define PLCG1 as a disease-associated gene with diverse missense variants contributing to phenotypic heterogeneity.
Thomas Balligand, Claire Carpenet ... Maarten Dewilde
Two radio-labeled nanobodies and a single knock-in mouse model suffice to track the biodistribution of various unmodified cell-types in live mice by PET/CT.
Mendelian randomization offers novel insights into the genetic factors that influence the aging process through early-life reproductive events, providing robust evidence for the antagonistic pleiotropy theory in humans.
Exercise intensity alone does not differentially reduce pain, but individual factors like fitness level and sex, along with opioid mechanisms, may influence exercise-induced pain relief.
Neoadjuvant SBRT with dalpiciclib and exemestane resulted in a 16.7% RCB 0-I rate and a 91.7% ORR, with acceptable toxicities in HR-positive, HER2-negative breast cancer patients.
Changli Zhang, Martha Elena Diaz-Hernandez ... Hicham Drissi
PDGF mitigated cellular senescence in human intervertebral disc by modulating cell cycle, inflammation, and mitochondria function, offering a potential strategy for combating age-induced disc degeneration.
EPHA4 pathway dysfunction causes axon pathfinding defects, resulting in impaired coordinated left-right locomotion by disrupting neural patterning and the function of central pattern generators, thereby potentially leading to idiopathic scoliosis.
CHMP5 is crucial in preventing skeletal progenitor cell senescence and abnormal bone formation, and senolytic drugs represent potential therapeutic medicine for musculoskeletal abnormalities associated with a dysfunctional endolysosomal pathway.
M Reza Bahranifard, Jessica Chan ... C Ross Ethier
Magnetically steered mesenchymal stem cells significantly lowered intraocular pressure for 9 months in mice, motivating the translation of this technology for the treatment of glaucoma.
