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    1. Medicine
    2. Immunology and Inflammation

    A translational transcriptomic signature of vaccine reactogenicity for the evaluation of novel formulations

    Jérémie Becker, Maroussia Roelens ... Laurent Beloeil
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Medicine
    2. Neuroscience

    Juvenile reinstatement of TCF4 in Pitt-Hopkins syndrome model mice reveals a critical window for genetic intervention

    Lucas M James, Carlee A Friar ... Benjamin D Philpot
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Medicine

    The inactivation of DHHC7 in mouse liver promotes diet-induced obesity through a hepatic Prg4–GPR146 axis

    Yingmin Sun, Ying Liu ... Bing Chen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Medicine
    2. Immunology and Inflammation

    Endothelial TLR4 signaling drives tissue inflammation, Claudin-5 internalization, and vascular barrier breakdown in a mouse model of neonatal meningitis

    Philip V Seegren, Amir Rattner ... Jeremy Nathans
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Medicine
    2. Structural Biology and Molecular Biophysics

    Medical Imaging: MRI sets its sights on collagen

    Fritz Schick
    Reducing the echo time of a whole-body MRI scanner makes it possible to image collagen, an important structural protein found in bones and tendons.
    Version of Record
    Insight
    1. Medicine
    2. Stem Cells and Regenerative Medicine

    A titin missense variant drives atrial electrical remodeling and is associated with atrial fibrillation

    Mahmud Arif Pavel, Hanna Chen ... Dawood Darbar
    Genetic and electrophysiological studies uncover a mechanism linking a TTN missense variant to atrial fibrillation by coupling titin with potassium channel remodeling, revealing FHL2 as a modulator and therapeutic target.
    1. Medicine

    Association between continuous glucose monitoring-derived metrics and coronary plaque vulnerability: A retrospective exploratory analysis

    Hikaru Sugimoto, Ken-ichi Hironaka ... Shinya Kuroda
    The mean, variance, and autocorrelation of glucose dynamics are independently associated with coronary plaque vulnerability.
    1. Medicine
    2. Immunology and Inflammation

    PDL-1+ Neutrophils mediate susceptibility during endotoxemia in Metabolically Dysfunctional-Associated Fatty Liver Disease

    Cleyson da Cruz Oliveira Barros, Alexandre Kanashiro ... Fernando Queiroz Cunha
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Medicine
    2. Neuroscience

    Impaired Adaptive Learning in Chronic Pain Contributes to Apathy

    Xinyuan Yan, Crina M Peterson ... David P Darrow
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Genetics and Genomics
    2. Medicine

    Translational reading frame determines the pathogenicity of C-terminal frameshift deletions in MeCP2: an alternative therapeutic approach

    Jacky Guy, Elena Hein ... Adrian Bird
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
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