Insights

Insight articles are related to original research papers in eLife and explain why the results reported in the paper are significant in a given field of research. Insight articles are commissioned by eLife staff.

Latest articles

    1. Immunology and Inflammation

    Bacterial Clearance: With a little help from T cells

    Troy Burtchett, Neal Hammer
    Specific host factors, such as immune cell activity, sex hormones and microbiota composition, influence the ability of Staphylococcus aureus bacteria to colonize the gut of mice.
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    Insight
    1. Neuroscience

    Cognition: When working memory works for our goals

    Jacob A Miller
    When navigating environments with changing rules, human brain circuits flexibly adapt how and where we retain information to help us achieve our immediate goals.
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    Insight
    1. Cancer Biology
    2. Cell Biology

    Breast Cancer: How cell crowding causes cancer cells to spread

    Rui Hua, Jean X Jiang
    Cell crowding causes high-grade breast cancer cells to become more invasive by activating a molecular switch that causes the cells to shrink and spread.
    Version of Record
    Insight
    1. Neuroscience

    Pain: Revisiting the role of Substance P and CGRPα

    Weihua Cai, Arkady Khoutorsky
    Mice lacking two neuropeptides thought to be essential for processing pain show no change in how they respond to a wide range of harmful stimuli.
    Version of Record
    Insight
    1. Genetics and Genomics
    2. Neuroscience

    Neuronal Signaling: Cell-specific tools for understanding behavior

    Brandon L Holder, Stephane Dissel
    Novel tools that allow neuron-specific investigations of the structure controlling sleep regulation in fruit flies reveal the extent of neuronal heterogeneity.
    Version of Record
    Insight
    1. Cell Biology
    2. Medicine

    Pulmonary Hypertension: When cell teamwork turns toxic

    Wadih EI Khoury, Stephen Y Chan
    In pulmonary hypertension, a combination of metabolic and mechanical dysfunction leads to irreversible vascular damage.
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    Insight
    1. Neuroscience

    Neuronal Signaling: At the crossroads of calcium signaling, protein synthesis and neuropeptide release

    Jakob Rupert, Dragomir Milovanovic
    By influencing calcium homeostasis, local protein synthesis and the endoplasmic reticulum, a small protein called Rab10 emerges as a crucial cytoplasmic regulator of neuropeptide secretion.
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    Insight
    1. Cell Biology
    2. Developmental Biology

    Lens Development: Bringing signaling complexity into focus

    Sarah Y Coomson, Salil A Lachke
    A study in mice reveals key interactions between proteins involved in fibroblast growth factor signaling and how they contribute to distinct stages of eye lens development.
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    Insight
    1. Immunology and Inflammation

    Inflammasomes: A tale of two caspases

    Denise M Monack
    Macrophages control intracellular pathogens like Salmonella by using two caspase enzymes at different times during infection.
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    Insight
    1. Neuroscience

    Memory: Integrating past experiences

    Thomas MW Leir, Matthew PH Gardner
    New results help address a longstanding debate regarding which learning strategies allow animals to anticipate negative events based on past associations between sensory stimuli.
    Version of Record
    Insight