Cancer Biology

Cancer Biology

eLife reviews research into cancer spanning from oncogenes and tumor suppressors to metastasis and anticancer treatments. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Cell Biology
    2. Cancer Biology

    Human RAP2A Homolog of the Drosophila Asymmetric Cell Division Regulator Rap2l Targets the Stemness of Glioblastoma Stem Cells

    Maribel Franco, Ricardo Gargini ... Ana Carmena
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Cancer Biology

    Defined cellular reprogramming of androgen receptor-active prostate cancer to neuroendocrine prostate cancer

    Shan Li, Kai Song ... John K Lee
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    1. Cancer Biology

    Molecular Feature-Based Classification of Retroperitoneal Liposarcoma: A Prospective Cohort Study

    Mengmeng Xiao, Xiangji Li ... Li Min
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Cell Biology
    2. Cancer Biology

    Tumor Cell Spatial Organization Directs EGFR/RAS/RAF Pathway Primary Therapy Resistance through YAP Signaling

    Rachel Nakagawa, Andrew Beardsley ... Andrei Goga
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cancer Biology
    2. Cell Biology

    Changes in local mineral homeostasis facilitate the formation of benign and malignant testicular microcalcifications

    Ida Marie Boisen, Nadia Krarup Knudsen ... Martin Blomberg Jensen
    Testicular microcalcifications arise secondary to local alterations in mineral homeostasis, which in combination with impaired Sertoli cell function and reduced levels of mineralization inhibitors facilitate deposition of hydroxyapatite.
    1. Cancer Biology

    Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis

    Patrick B Jonker, Mumina Sadullozoda ... Alexander Muir
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Cell Biology
    2. Cancer Biology

    A single cysteine residue in vimentin regulates long non-coding RNA XIST to suppress epithelial-mesenchymal transition and stemness in breast cancer

    Saima Usman, W Andrew Yeudall ... Ahmad Waseem
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Cancer Biology

    Targeting SLC7A11-mediated cysteine metabolism for the treatment of trastuzumab resistant HER2 positive breast cancer

    Yijia Hua, Ningjun Duan ... Yongmei Yin
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Compelling
    1. Cancer Biology

    TAK1-mediated phosphorylation of PLCE1 represses PIP2 hydrolysis to impede esophageal squamous cancer metastasis

    Qianqian Ju, Wenjing Sheng ... Cheng Sun
    TAK1 plays a negative role in esophageal squamous cancer cell metastasis, which depends on the TAK1-induced phosphorylation of PLCE1 at S1060 and subsequent inhibition of PIP2 hydrolysis.
    1. Cell Biology
    2. Cancer Biology

    RUNX2 Isoform II Protects Cancer Cells from Ferroptosis and Apoptosis by Promoting PRDX2 Expression in Oral Squamous Cell Carcinoma

    Junjun Huang, Rong Jia, Jihua Guo
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
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Highlights

    1. Cancer Biology
    2. Cell Biology

    Cell crowding and cancer

    Rui Hua, Jean X Jiang
    1. Cancer Biology

    Reproducibility in Cancer Biology

    Edited by Roger J Davis et al.
    1. Cancer Biology
    2. Computational and Systems Biology

    eLife publishes final papers from the Reproducibility Project: Cancer Biology

    Timothy M Errington, Maya Mathur ... Brian A Nosek

Senior editors

  1. Yamini Dalal
    National Cancer Institute, United States
  2. Caigang Liu
    Shengjing Hospital of China Medical University, China
  3. Tony Ng
    King's College London, United Kingdom
  4. See more editors