Structural Biology and Molecular Biophysics

Latest articles

1. 1. Structural Biology and Molecular Biophysics

   ATP-release pannexin channels are gated by lysophospholipids

   Erik Henze, Russell N Burkhardt ... Toshimitsu Kawate

   Lysophospholipids directly and reversibly activate pannexin channels, triggering the release of signaling molecules critical for inflammation.
2. 1. Structural Biology and Molecular Biophysics

   Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization

   Mia L Abramsson, Robin A Corey ... Michael Landreh

   Bulding a cardiolipin binding site into a computationally designed transmembrane protein uncovers how proteins can recognize specific lipids and use them to regulate their function.
3. 1. Structural Biology and Molecular Biophysics

   Hidden GPCR structural transitions addressed by multiple walker supervised molecular dynamics (mwSuMD)

   Giuseppe Deganutti, Ludovico Pipito ... Christopher Arthur Reynolds

   Multiple walker supervised molecular dynamics simulations deliver insights on glucagon-like peptide 1 receptor activation, G_s protein binding, and guanosine diphosphate release from the G_sα subunit using an adaptive sampling approach.
4. 1. Structural Biology and Molecular Biophysics

   Structural and Dynamic Impacts of Single-atom Disruptions to Guide RNA Interactions within the Recognition Lobe of Geobacillus stearothermophilus Cas9

   Helen B Belato, Alexa L Knight ... George P Lisi
5. 1. Structural Biology and Molecular Biophysics

   LC8 enhances 53BP1 foci through heterogeneous bridging of 53BP1 oligomers

   Jesse Howe, Douglas Walker ... Elisar J Barbar
6. 1. Structural Biology and Molecular Biophysics
   2. Computational and Systems Biology

   Atomistic Simulation of Voltage Activation of a Truncated BK Channel

   Zhiguang Jia, Jianhan Chen
7. 1. Immunology and Inflammation
   2. Structural Biology and Molecular Biophysics

   Simultaneous polyclonal antibody sequencing and epitope mapping by cryo electron microscopy and mass spectrometry

   Douwe Schulte, Marta Šiborová ... Joost Snijder

   Germline V-gene usage can be inferred from cryoEM reconstructions of antigen-antibody complexes to guide de novo antibody sequencing of complex mixtures by mass spectrometry.
8. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Development of D-box peptides to inhibit the Anaphase Promoting Complex/Cyclosome

   Rohan Eapen, Cynthia Okoye ... Laura S Itzhaki
9. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Kinetic regulation of kinesin’s two motor domains coordinates its stepping along microtubules

   Yamato Niitani, Kohei Matsuzaki ... Michio Tomishige

   Kinetic measurements of kinesin-1's front and rear heads reveal how different neck linker orientation regulate their activity, enabling the motor protein to move in a coordinated manner along microtubules.
10. 1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Structure-Guided Loop Grafting Improves Expression and Stability of Influenza Neuraminidase for Vaccine Development

    Pramila Rijal, Leiyan Wei ... Alain RM Townsend