Genetics and Genomics

Latest articles

1. 1. Cell Biology
   2. Genetics and Genomics

   Robust single nucleus RNA sequencing reveals depot-specific cell population dynamics in adipose tissue remodeling during obesity

   Jisun So, Olivia Strobel ... Hyun Cheol Roh
2. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Spotless, a reproducible pipeline for benchmarking cell type deconvolution in spatial transcriptomics

   Chananchida Sang-aram, Robin Browaeys ... Yvan Saeys

   Estimating cell type composition from a gene expression mixture remains a challenging task, as evidenced by how a simple regression model outperforms many state-of-the-art spatial deconvolution methods.
3. 1. Genetics and Genomics
   2. Neuroscience

   Biobank-wide association scan identifies risk factors for late-onset Alzheimer’s disease and endophenotypes

   Donghui Yan, Bowen Hu ... Qiongshi Lu

   BADGERS, as a new powerful method for conducting polygenic score-based biobank-wide association scans, identified 48 significant associations for AD and 41 significant associations for a variety of AD endophenotypes.
4. 1. Genetics and Genomics
   2. Cancer Biology

   Circulating Small Extracellular Vesicle RNA Profiling for the Detection of T1a stage Colorectal Cancer and Precancerous Advanced Adenoma

   Li Min, Fanqin Bu ... Shutian Zhang
5. 1. Genetics and Genomics

   Specific Modulation of CRISPR Transcriptional Activators through RNA-Sensing Guide RNAs in Mammalian Cells and Zebrafish Embryos

   Oana Pelea, Sarah Mayes ... Tatjana Sauka-Spengler
6. 1. Genetics and Genomics
   2. Medicine

   Impaired central pattern generators due to abnormal EPHA4 signaling leads to idiopathic scoliosis

   Lianlei Wang, Sen Zhao ... Nan Wu
7. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   Signatures of transposon-mediated genome inflation, host specialization, and photoentrainment in Entomophthora muscae and allied entomophthoralean fungi

   Jason E Stajich, Brian Lovett ... Carolyn Elya

   Entomophthora muscae has one of the largest fungal genomes (1.03 Gb) owing to extensive proliferation of transposable elements.
8. 1. Evolutionary Biology
   2. Genetics and Genomics

   Epistasis facilitates functional evolution in an ancient transcription factor

   Brian PH Metzger, Yeonwoo Park ... Joseph W Thornton

   A complete mutational scan of a protein-DNA interface shows that pairwise epistatic interactions among amino acids determine a transcription factor's specificity for DNA and facilitate the evolution of new functions.
9. 1. Cell Biology
   2. Genetics and Genomics

   SCC3 is an axial element essential for homologous chromosome pairing and synapsis

   Yangzi Zhao, Lijun Ren ... Zhukuan Cheng
10. 1. Cell Biology
    2. Genetics and Genomics

    Aberrant methylation and expression of TNXB promotes chondrocyte apoptosis and extracullar matrix degradation in hemophilic arthropathy via AKT signaling

    Jiali Chen, Zeng Qinghe ... Hongting Jin