Stability-mediated epistasis constrains the evolution of an influenza protein

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Stability-mediated epistasis constrains the evolution of an influenza protein

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DOI: http://dx.doi.org/10.7554/eLife.00631Published May 14, 2013Cite as eLife 2013;2:e00631

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Author contributions

  • LIG, Performed the experiments, analyzed the data, and wrote the manuscript

  • MAS, Developed the probabilistic techniques and performed the computational work, analyzed the data, and wrote the manuscript

  • JDB, Designed the study, performed the computational work, analyzed the data, wrote the manuscript

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Competing interests

  • The authors declare that no competing interests exist.

Funding

National Institutes of Health1 R01 GM102198-01Lizhi Ian GongJesse D BloomNational Institutes of Health1 R01 GM086887-05Marc A SuchardThe funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

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