Latest research

The budding yeast Centromere DNA Element II wraps a stable Cse4 hemisome in either orientation in vivo
A stable tetrameric nucleosome occupies the central segment of each ∼120-bp budding yeast centromere in two rotational phases of both reflectional orientations in vivo.
Steven Henikoff, Srinivas Ramachandran, Kristina Krassovsky, Terri D Bryson, Christine A Codomo, Kristin Brogaard, Jonathan Widom, Ji-Ping Wang, Jorja G Henikoff
The nucleosomal barrier to promoter escape by RNA polymerase II is overcome by the chromatin remodeler Chd1
The ATP-dependent chromatin remodeler Chd1 controls nucleosome turnover to allow RNA Polymerase to transcribe in vivo.
Peter J Skene, Aaron E Hernandez, Mark Groudine, Steven Henikoff
The influence of dynein processivity control, MAPs, and microtubule ends on directional movement of a localising mRNA
In vitro reconstitution of mRNA motility reveals the basis of directionally biased motion by groups of motors, their response to potential obstacles, and the consequences of reaching microtubule ends.
Harish Chandra Soundararajan, Simon L Bullock
Selective amputation of the pharynx identifies a FoxA-dependent regeneration program in planaria
A chemical method has been developed for studying single organ regeneration and fate specification of stem cells in an adult organism.
Carolyn E Adler, Chris W Seidel, Sean A McKinney, Alejandro Sánchez Alvarado
FRET-based reporters for the direct visualization of abscisic acid concentration changes and distribution in Arabidopsis
Fluorescent sensors can track the movement and distribution of the plant hormone abscisic acid in roots and leaves in Arabidopsis.
Rainer Waadt, Kenichi Hitomi, Noriyuki Nishimura, Chiharu Hitomi, Stephen R Adams, Elizabeth D Getzoff, Julian I Schroeder
Abscisic acid dynamics in roots detected with genetically encoded FRET sensors
Fluorescent sensors for the hormone abscisic acid have been developed using a high-throughput platform, and used to monitor hormone dynamics in plant roots and leaves.
Alexander M Jones, Jonas ÅH Danielson, Shruti N ManojKumar, Viviane Lanquar, Guido Grossmann, Wolf B Frommer
Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution
LRH-1/NR5A2 responds to ER stress by inducing a novel pathway that is required for stress resolution in mice and can be targeted by LRH-1 agonists.
Jennifer L Mamrosh, Jae Man Lee, Martin Wagner, Peter J Stambrook, Richard J Whitby, Richard N Sifers, San-Pin Wu, Ming-Jer Tsai, Francesco J DeMayo, David D Moore
T cells translate individual, quantal activation into collective, analog cytokine responses via time-integrated feedbacks
Experiment-driven quantitative model of IL-2 secretion demonstrates how T cells integrate their digital antigen responses into an analog-scaled output.
Karen E Tkach, Debashis Barik, Guillaume Voisinne, Nicole Malandro, Matthew M Hathorn, Jesse W Cotari, Robert Vogel, Taha Merghoub, Jedd Wolchok, Oleg Krichevsky, Grégoire Altan-Bonnet
Holocentromeres are dispersed point centromeres localized at transcription factor hotspots
Worm holocentromeres show a polycentric distribution, with each site containing a single centromeric nucleosome and also being targeted by multiple transcription factors.
Florian A Steiner, Steven Henikoff
In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes
Combinations of transcription factors can convert pancreatic acinar cells into endocrine α-, β- and δ-cells in vivo.
Weida Li, Mio Nakanishi, Adrian Zumsteg, Matthew Shear, Christopher Wright, Douglas A Melton, Qiao Zhou
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