Latest research

Subcellular and supracellular mechanical stress prescribes cytoskeleton behavior in Arabidopsis cotyledon pavement cells
In the Arabidopsis epidermis, the internal mechanical stress of a cell competes with the external stress to control microtubule behavior, providing a framework to understand the mechanical feedbacks that underlie plant morphogenesis.
Arun Sampathkumar, Pawel Krupinski, Raymond Wightman, Pascale Milani, Alexandre Berquand, Arezki Boudaoud, Olivier Hamant, Henrik Jönsson, Elliot M Meyerowitz
The influence of dynein processivity control, MAPs, and microtubule ends on directional movement of a localising mRNA
In vitro reconstitution of mRNA motility reveals the basis of directionally biased motion by groups of motors, their response to potential obstacles, and the consequences of reaching microtubule ends.
Harish Chandra Soundararajan, Simon L Bullock
Selective amputation of the pharynx identifies a FoxA-dependent regeneration program in planaria
A chemical method has been developed for studying single organ regeneration and fate specification of stem cells in an adult organism.
Carolyn E Adler, Chris W Seidel, Sean A McKinney, Alejandro Sánchez Alvarado
FRET-based reporters for the direct visualization of abscisic acid concentration changes and distribution in Arabidopsis
Fluorescent sensors can track the movement and distribution of the plant hormone abscisic acid in roots and leaves in Arabidopsis.
Rainer Waadt, Kenichi Hitomi, Noriyuki Nishimura, Chiharu Hitomi, Stephen R Adams, Elizabeth D Getzoff, Julian I Schroeder
Abscisic acid dynamics in roots detected with genetically encoded FRET sensors
Fluorescent sensors for the hormone abscisic acid have been developed using a high-throughput platform, and used to monitor hormone dynamics in plant roots and leaves.
Alexander M Jones, Jonas ÅH Danielson, Shruti N ManojKumar, Viviane Lanquar, Guido Grossmann, Wolf B Frommer
Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution
LRH-1/NR5A2 responds to ER stress by inducing a novel pathway that is required for stress resolution in mice and can be targeted by LRH-1 agonists.
Jennifer L Mamrosh, Jae Man Lee, Martin Wagner, Peter J Stambrook, Richard J Whitby, Richard N Sifers, San-Pin Wu, Ming-Jer Tsai, Francesco J DeMayo, David D Moore
The budding yeast Centromere DNA Element II wraps a stable Cse4 hemisome in either orientation in vivo
A stable tetrameric nucleosome occupies the central segment of each ∼120-bp budding yeast centromere in two rotational phases of both reflectional orientations in vivo.
Steven Henikoff, Srinivas Ramachandran, Kristina Krassovsky, Terri D Bryson, Christine A Codomo, Kristin Brogaard, Jonathan Widom, Ji-Ping Wang, Jorja G Henikoff
The nucleosomal barrier to promoter escape by RNA polymerase II is overcome by the chromatin remodeler Chd1
The ATP-dependent chromatin remodeler Chd1 controls nucleosome turnover to allow RNA Polymerase to transcribe in vivo.
Peter J Skene, Aaron E Hernandez, Mark Groudine, Steven Henikoff
T cells translate individual, quantal activation into collective, analog cytokine responses via time-integrated feedbacks
Experiment-driven quantitative model of IL-2 secretion demonstrates how T cells integrate their digital antigen responses into an analog-scaled output.
Karen E Tkach, Debashis Barik, Guillaume Voisinne, Nicole Malandro, Matthew M Hathorn, Jesse W Cotari, Robert Vogel, Taha Merghoub, Jedd Wolchok, Oleg Krichevsky, Grégoire Altan-Bonnet
A frontal cortex event-related potential driven by the basal forebrain
Contrary to the common belief that cognitive event-related potentials are generated by local activity within the cerebral cortex, it is shown that some of these potentials are modulated by subcortical inputs.
David P Nguyen, Shih-Chieh Lin

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