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Lhx1 maintains synchrony among circadian oscillator neurons of the SCN
A transcription factor called Lhx1 coordinates the activity of the brain's master circadian clock, the suprachiasmatic nucleus, by controlling communication between its constituent cells.
Megumi Hatori, Shubhroz Gill, Ludovic S Mure, Martyn Goulding, Dennis D M O'Leary, Satchidananda Panda
Bidirectional helical motility of cytoplasmic dynein around microtubules
Unlike other cytoskeletal motors that produce torque in a specific direction, cytoplasmic dynein generates torque in either direction, resulting in bidirectional helical motility along microtubules.
Sinan Can, Mark A Dewitt, Ahmet Yildiz
Quantitative analysis of mammalian GIRK2 channel regulation by G proteins, the signaling lipid PIP2 and Na+ in a reconstituted system
The G protein subunits Gβγ and the signaling lipid PIP2 are simultaneously needed to activate the potassium ion channel GIRK2 to control the voltage across a lipid bilayer, while sodium ions modulate these molecules' effects.
Weiwei Wang, Matthew R Whorton, Roderick MacKinnon
Shared mushroom body circuits underlie visual and olfactory memories in Drosophila
One memory center in the fly brain processes distinct appetitive and aversive associative memories of olfactory and visual cues using shared local circuits.
Katrin Vogt, Christopher Schnaitmann, Kristina V Dylla, Stephan Knapek, Yoshinori Aso, Gerald M Rubin, Hiromu Tanimoto
The master cell cycle regulator APC-Cdc20 regulates ciliary length and disassembly of the primary cilium
The anaphase promoting complex (APC) has an essential role in ubiquitin-mediated proteolysis in the disassembly of cilia.
Weiping Wang, Tao Wu, Marc W Kirschner
Autism and attention-deficit/hyperactivity disorder among individuals with a family history of alcohol use disorders
A Swedish national cohort study reveals that children with a family history of alcohol use disorders have an increased risk of autism and attention-deficit/hyperactivity disorder.
Jan Sundquist, Kristina Sundquist, Jianguang Ji
A suppression hierarchy among competing motor programs drives sequential grooming in Drosophila
Gaining genetic control over neural modules that drive the grooming of each Drosophila body part reveals how mechanisms for selecting among competing behavioral choices are used to generate sequences of actions.
Andrew M Seeds, Primoz Ravbar, Phuong Chung, Stefanie Hampel, Frank M Midgley Jr, Brett D Mensh, Julie H Simpson
The metal transporter ZIP13 supplies iron into the secretory pathway in Drosophila melanogaster
Drosophila ZIP13 (Slc39a13), a presumed zinc importer, is responsible for iron delivery to the secretory pathway.
Guiran Xiao, Zhihui Wan, Qiangwang Fan, Xiaona Tang, Bing Zhou
Redox signaling via the molecular chaperone BiP protects cells against endoplasmic reticulum-derived oxidative stress
Direct modification by endogenous peroxide of a conserved cysteine in the molecular chaperone BiP decouples its ATPase and peptide-binding activities, allowing for enhanced polypeptide holdase activity during oxidative stress.
Jie Wang, Kristeen A Pareja, Chris A Kaiser, Carolyn S Sevier
Orbitofrontal neurons acquire responses to ‘valueless’ Pavlovian cues during unblocking
Orbitofrontal cortex neurons fire in response to cues with no value independent of what can be inferred through features of the predicted outcome.
Michael A McDannald, Guillem R Esber, Meredyth A Wegener, Heather M Wied, Tzu-Lan Liu, Thomas A Stalnaker, Joshua L Jones, Jason Trageser, Geoffrey Schoenbaum
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