Latest research

Divergent mechanisms regulate conserved cardiopharyngeal development and gene expression in distantly related ascidians
Embryos of distantly related sea squirt species are nearly identical but develop according to different gene regulatory mechanisms.
Alberto Stolfi, Elijah K Lowe, Claudia Racioppi, Filomena Ristoratore, C Titus Brown, Billie J Swalla, Lionel Christiaen
Research article
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A critical role for mTORC1 in erythropoiesis and anemia
Transcription profiling of activated cells using Phospho-Trap, a new method for identifying activated cells, reveals a critical role for mTOR signaling in red blood cell development and the pathogenesis of anemia
Zachary A Knight, Sarah F Schmidt, Kivanc Birsoy, Keith Tan, Jeffrey M Friedman
Research article
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Cannabinoid-induced actomyosin contractility shapes neuronal morphology and growth
Cannabinoids inhibit neuronal expansion and growth through the rapid contraction of actomyosin.
Alexandre B Roland, Ana Ricobaraza, Damien Carrel, Benjamin M Jordan, Felix Rico, Anne Simon, Marie Humbert-Claude, Jeremy Ferrier, Maureen H McFadden, Simon Scheuring, Zsolt Lenkei
Research article
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Regulation of retinal axon growth by secreted Vax1 homeodomain protein
Secreted Vax1 homeodomain protein supports the development of optic chiasm by directly acting at the retinal ganglion cell axon.
Namsuk Kim, Kwang Wook Min, Kyung Hwa Kang, Eun Jung Lee, Hyoung-Tai Kim, Kyunghwan Moon, Jiheon Choi, Dai Le, Sang-Hee Lee, Jin Woo Kim
Research article
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Analysis of the crystal structure of an active MCM hexamer
Building on previous work (Froelich et al., 2014), we present the X-ray crystal structure of an active MCM hexamer, which suggests a mechanism for MCM regulation and demonstrates a key interaction between the major domains.
Justin M Miller, Buenafe T Arachea, Leslie B Epling, Eric J Enemark
Research advance
A molecular mechanism of mitotic centrosome assembly in Drosophila
The proteins DSpd-2 and Centrosomin assemble into dynamic scaffolds that build from the inside out around the mother centriole and support centrosome maturation.
Paul T Conduit, Jennifer H Richens, Alan Wainman, James Holder, Catarina C Vicente, Metta B Pratt, Carly I Dix, Zsofia A Novak, Ian M Dobbie, Lothar Schermelleh, Jordan W Raff
Research article
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Mother-daughter asymmetry of pH underlies aging and rejuvenation in yeast
Protons are pumped out of mother cells by a protein that accumulates over time and this leads to cellular aging, but this protein is largely absent from daughter cells, which mediates rejuvenation.
Kiersten A Henderson, Adam L Hughes, Daniel E Gottschling
Short report
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Divergent kleisin subunits of cohesin specify mechanisms to tether and release meiotic chromosomes
Mechanisms that tether and release replicated sister chromatids to produce sperm and eggs rely extensively on meiotic cohesin complexes that are endowed with unexpectedly different properties specified by a single interchangeable subunit, the α-kleisin.
Aaron F Severson, Barbara J Meyer
Research article
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Cross-synaptic synchrony and transmission of signal and noise across the mouse retina
Cells within the retina synchronize transmitter release across their output synapses in the dark, reducing the impact of noise generated at these synapses and allowing light-dependent signals to be transmitted with minimal added synaptic noise.
William N Grimes, Mrinalini Hoon, Kevin L Briggman, Rachel O Wong, Fred Rieke
Research article
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Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states
Fringe proteins modulate cis inhibitory, same-cell interactions between the Notch receptor and its ligands to control whether, and in which direction, cells can signal to one another.
Lauren LeBon, Tom V Lee, Hamed Jafar-Nejad, David Sprinzak, Michael B Elowitz
Research article
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