Latest research

Active invasion of bacteria into living fungal cells
Bacteria invade living fungal cells using secreted chitinolytic enzymes that allow for a traceless entry, as shown by microscopic snapshots.
Nadine Moebius, Zerrin Üzüm, Jan Dijksterhuis, Gerald Lackner, Christian Hertweck
Research article
|
Extensive translation of small Open Reading Frames revealed by Poly-Ribo-Seq
Thousands of small Open Reading Frames are translated, and form two distinct classes based on their translational efficiency and bioinformatic indicators.
Julie L Aspden, Ying Chen Eyre-Walker, Rose J Phillips, Unum Amin, Muhammad Ali S Mumtaz, Michele Brocard, Juan-Pablo Couso
Research article
|
A receptor-like kinase mutant with absent endodermal diffusion barrier displays selective nutrient homeostasis defects
The SCHENGEN3 protein is needed for the progression of isolated microdomains into a continuous band, which is necessary for the establishment of the major extracellular diffusion barrier in plant roots: the Casparian strip.
Alexandre Pfister, Marie Barberon, Julien Alassimone, Lothar Kalmbach, Yuree Lee, Joop EM Vermeer, Misako Yamazaki, Guowei Li, Christophe Maurel, Junpei Takano, Takehiro Kamiya, David E Salt, Daniele Roppolo, Niko Geldner
Research article
Ecology and evolution of viruses infecting uncultivated SUP05 bacteria as revealed by single-cell- and meta-genomics
Single-cell amplified genome sequencing uncovers virus-host interactions in uncultivated sulfur-oxidizing bacteria with relevance to coupled biogeochemical cycling in marine oxygen minimum zones.
Simon Roux, Alyse K Hawley, Monica Torres Beltran, Melanie Scofield, Patrick Schwientek, Ramunas Stepanauskas, Tanja Woyke, Steven J Hallam, Matthew B Sullivan
Research article
|
Long non-coding RNAs as a source of new peptides
Ribosome profiling data from several eukaryotic species provides strong evidence that many long non-coding RNA molecules encode novel short proteins.
Jorge Ruiz-Orera, Xavier Messeguer, Juan Antonio Subirana, M Mar Alba
Research article
The translation elongation factor eEF1A1 couples transcription to translation during heat shock response
Eukaryotic translation elongation factor 1A1 controls the process of heat shock response, from transcriptional activation of the HSP70 gene, to HSP70 mRNA stabilization, nuclear export, and translation.
Maria Vera, Bibhusita Pani, Lowri A Griffiths, Christian Muchardt, Catherine M Abbott, Robert H Singer, Evgeny Nudler
Research article
Selection of chromosomal DNA libraries using a multiplex CRISPR system
An optimized CRISPR-Cas9 system enables multiplexed genome engineering for evolving biomolecules and pathways from chromosomally integrated DNA libraries.
Owen W Ryan, Jeffrey M Skerker, Matthew J Maurer, Xin Li, Jordan C Tsai, Snigdha Poddar, Michael E Lee, Will DeLoache, John E Dueber, Adam P Arkin, Jamie HD Cate
Research article
|
Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis
The ribosomal protein, Rps27l, plays an oncogenic role by promoting p53 degradation via stabilizing the Mdm2-Mdm4 complex, but a tumor suppressor role by preventing the aneuploidy and loss of p53 heterozygosity.
Xiufang Xiong, Yongchao Zhao, Fei Tang, Dongping Wei, Daffyd Thomas, Xiang Wang, Yang Liu, Pan Zheng, Yi Sun
Research article
|
Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin-coated pits
Epsin has a key role in the coupling of actin to endocytic clathrin coated pits that is required for their maturation and helps capture SNAREs at endocytic clathrin coated pits.
Mirko Messa, Rubén Fernández-Busnadiego, Elizabeth Wen Sun, Hong Chen, Heather Czapla, Kristie Wrasman, Yumei Wu, Genevieve Ko, Theodora Ross, Beverly Wendland, Pietro De Camilli
Research article
|
A RanGTP-independent mechanism allows ribosomal protein nuclear import for ribosome assembly
The Tsr2 carrier protein connects the nuclear import machinery with the ribosome assembly pathway.
Sabina Schütz, Ute Fischer, Martin Altvater, Purnima Nerurkar, Cohue Peña, Michaela Gerber, Yiming Chang, Stefanie Caesar, Olga T Schubert, Gabriel Schlenstedt, Vikram G Panse
Research article
|
More articles
Randy Schekman Editor-in-Chief, Nobel Prize winner 2013

Early in your career?

eLife editors want early-career scientists to thrive – to receive clear and constructive input on papers, quick decisions, and great exposure. In addition to pain-free peer review, we offer early-career scientists a letter of recommendation from one of our senior editors.

Read more about publishing with eLife