Latest research

The neural crest is a source of mesenchymal stem cells with specialized hematopoietic stem cell niche function
Developing long bones contain distinct mesenchymal stem-cell populations derived from mesoderm and neural crest, which have specialized functions in skeleton formation and the establishment of the hematopoietic stem-cell niche, respectively.
Joan Isern, Andrés García-García, Ana M Martín, Lorena Arranz, Daniel Martín-Pérez, Carlos Torroja, Fátima Sánchez-Cabo, Simón Méndez-Ferrer
Research article
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Polycomb- and REST-associated histone deacetylases are independent pathways toward a mature neuronal phenotype
Poised neuronal genes are repressed by REST and Polycomb in embryonic stem cells independently and via different chromatin modifications.
James C McGann, Jon A Oyer, Saurabh Garg, Huilan Yao, Jun Liu, Xin Feng, Lujian Liao, John R Yates III, Gail Mandel
Research article
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A distinct tethering step is vital for vacuole membrane fusion
Rigorous assays of membrane fusion show that a distinct tethering step is required for lumenal compartment mixing in a manner that extends beyond simply increasing the amount of total trans-SNARE complex.
Michael Zick, William T Wickner
Research article
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Epidemiological dynamics of Ebola outbreaks
The pattern of past Ebola outbreaks is indicative of an effective reproductive ratio of less than 1, which can lead to the generation of a range of outbreak sizes consistent with the scale of the ongoing epidemic.
Thomas House
Short report
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HIV-1 DNA predicts disease progression and post-treatment virological control
Measuring HIV-1 DNA levels at the time of stopping antiretroviral therapy (when initiated during primary infection) predicts clinical progression and the time taken for plasma viraemia to become detectable.
James P Williams, Jacob Hurst, Wolfgang Stöhr, Nicola Robinson, Helen Brown, Martin Fisher, Sabine Kinloch, David Cooper, Mauro Schechter, Giuseppe Tambussi, Sarah Fidler, Mary Carrington, Abdel Babiker, Jonathan Weber, Kersten K Koelsch, Anthony D Kelleher, Rodney E Phillips, John Frater
Research article
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Peroxisomal lactate dehydrogenase is generated by translational readthrough in mammals
Whole-genome in silico screening for stop codon contexts that produce elevated translational readthrough and peroxisome targeting reveals that in mammals, the amount of lactate dehydrogenase in the peroxisome is controlled by translational readthrough.
Fabian Schueren, Thomas Lingner, Rosemol George, Julia Hofhuis, Corinna Dickel, Jutta Gärtner, Sven Thoms
Research article
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Oscillatory phase separation in giant lipid vesicles induced by transmembrane osmotic differentials
Spontaneous osmoregulation in giant phospholipid vesicles, which is characterized by oscillations in vesicle size and membrane tension, couples to the compositional degrees of freedom at the membrane surface to produce oscillations in domain texture and induce isothermal phase change.
Kamila Oglęcka, Padmini Rangamani, Bo Liedberg, Rachel S Kraut, Atul N Parikh
Research article
Dopamine receptor 1 neurons in the dorsal striatum regulate food anticipatory circadian activity rhythms in mice
For mice, knowing when it is time to feed is dependent on the neurotransmitter dopamine and the D1R receptor of neurons in the dorsal striatum.
Christian M Gallardo, Martin Darvas, Mia Oviatt, Chris H Chang, Mateusz Michalik, Timothy F Huddy, Emily E Meyer, Scott A Shuster, Antonio Aguayo, Elizabeth M Hill, Karun Kiani, Jonathan Ikpeazu, Johan S Martinez, Mari Purpura, Andrea N Smit, Danica F Patton, Ralph E Mistlberger, Richard D Palmiter, Andrew D Steele
Research article
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Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding
Interactions between Neuropilin-1 and VEGFR2, rather than VEGF-Neuropilin-1 binding, underlie Neuropilin-1's critical function in VEGF-mediated vascular development.
Maria V Gelfand, Nellwyn Hagan, Aleksandra Tata, Won-Jong Oh, Baptiste Lacoste, Kyu-Tae Kang, Justyna Kopycinska, Joyce Bischoff, Jia-Huai Wang, Chenghua Gu
Research article
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Counteracting suppression of CFTR and voltage-gated K+ channels by a bacterial pathogenic factor with the natural product tannic acid
Tannic acid acts as an ‘antidote’ against the negative effects of a bacterial enzyme, which can both aggravate cystic fibrosis and enable the anthrax bacteria to evade the immune responses elicited by a typical live vaccine.
Yajamana Ramu, Yanping Xu, Hyeon-Gyu Shin, Zhe Lu
Research article
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