Latest research

Optimal multisensory decision-making in a reaction-time task
Through a combination of modeling and experiments it is shown that humans can near-optimally accumulate decision-related evidence across time and cues even when reaction time is under their control.
Jan Drugowitsch, Gregory C DeAngelis, Eliana M Klier, Dora E Angelaki, Alexandre Pouget
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Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5
The GEF activity of Rabex-5 is weakly autoinhibited by its CC domain and activated by Rabaptin-5 and the two proteins work concertedly to activate Rab5.
Zhe Zhang, Tianlong Zhang, Shanshan Wang, Zhou Gong, Chun Tang, Jiangye Chen, Jianping Ding
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Global distribution maps of the leishmaniases
Maps defining environmental risk of the leishmaniases provide insights into the ecology of these diseases and identify regions to target public health measures and inform future burden estimates.
David M Pigott, Samir Bhatt, Nick Golding, Kirsten A Duda, Katherine E Battle, Oliver J Brady, Jane P Messina, Yves Balard, Patrick Bastien, Francine Pratlong, John S Brownstein, Clark C Freifeld, Sumiko R Mekaru, Peter W Gething, Dylan B George, Monica F Myers, Richard Reithinger, Simon I Hay
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Host-induced bacterial cell wall decomposition mediates pattern-triggered immunity in Arabidopsis
Arabidopsis lysozyme LYS1 generates soluble peptidoglycan fragments to mediate pattern-triggered immunity.
Xiaokun Liu, Heini M Grabherr, Roland Willmann, Dagmar Kolb, Frédéric Brunner, Ute Bertsche, Daniel Kühner, Mirita Franz-Wachtel, Bushra Amin, Georg Felix, Marc Ongena, Thorsten Nürnberger, Andrea A Gust
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A molecular model for the role of SYCP3 in meiotic chromosome organisation
A structural and biochemical study of human SYCP3 provides the first molecular model for the three-dimensional organisation that is imposed upon chromosomal DNA during meiosis and is essential for genetic exchange and fertility.
Johanna Liinamaria Syrjänen, Luca Pellegrini, Owen Richard Davies
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Caenorhabditis elegans male sensory-motor neurons and dopaminergic support cells couple ejaculation and post-ejaculatory behaviors
In nematode worms, the length of the male refractory period–the time between matings–is regulated by multiple transmitters including dopamine, which both promotes ejaculation and reduces the activity of males post-copulation.
Brigitte LeBoeuf, Paola Correa, Changhoon Jee, L René García
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Rett-causing mutations reveal two domains critical for MeCP2 function and for toxicity in MECP2 duplication syndrome mice
Transgenic mice with Rett-causing mutations in MeCP2 reveal that a basic cluster in the C-terminus of the protein binds DNA and that both the methyl-CpG binding domain and the transcriptional repression domain are necessary to elicit toxicity in MECP2 duplication syndrome.
Laura Dean Heckman, Maria H Chahrour, Huda Y Zoghbi
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The role of photorespiration during the evolution of C4 photosynthesis in the genus Flaveria
Metabolic exaptation of an anaplerotic nitrogen cycle between bundle sheath and mesophyll cells may explain the remarkably frequent convergent evolution of C4 photosynthesis.
Julia Mallmann, David Heckmann, Andrea Bräutigam, Martin J Lercher, Andreas PM Weber, Peter Westhoff, Udo Gowik
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Evolution of histone 2A for chromatin compaction in eukaryotes
The N-terminal domain in histone 2A serves as an evolutionary tool to enable greater chromatin compaction when genome size is disproportionately larger than the nuclear volume across eukaryotes.
Benjamin R Macadangdang, Amit Oberai, Tanya Spektor, Oscar A Campos, Fang Sheng, Michael F Carey, Maria Vogelauer, Siavash K Kurdistani
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Auxin efflux by PIN-FORMED proteins is activated by two different protein kinases, D6 PROTEIN KINASE and PINOID
Two protein kinases are required to activate auxin efflux transporters from plants.
Melina Zourelidou, Birgit Absmanner, Benjamin Weller, Inês CR Barbosa, Björn C Willige, Astrid Fastner, Verena Streit, Sarah A Port, Jean Colcombet, Sergio de la Fuente van Bentem, Heribert Hirt, Bernhard Kuster, Waltraud X Schulze, Ulrich Z Hammes, Claus Schwechheimer
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