Latest research

RGS7/Gβ5/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABABR-GIRK signaling
A critical regulator of inhibitory neurotransmitter signaling in the hippocampus has been identified in experiments on mice and been shown to play essential role in synaptic plasticity and memory.
Olga Ostrovskaya, Keqiang Xie, Ikuo Masuho, Ana Fajardo-Serrano, Rafael Lujan, Kevin Wickman, Kirill A. Martemyanov
SIR-2.1 integrates metabolic homeostasis with the reproductive neuromuscular excitability in early aging male Caenorhabditis elegans
A protein called SIR-2.1 helps to protect worms from the effects of aging by regulating metabolic processes that would otherwise generate damaging reactive oxygen species.
Xiaoyan Guo, L René García
Transgressions of compartment boundaries and cell reprogramming during regeneration in Drosophila
The reconstruction of damaged structures during regeneration requires cell reprogramming mediated by the up regulation of the JNK pathway and the transient debilitation of the epigenetic control mechanism.
Salvador C Herrera, Ginés Morata
Gating of neural error signals during motor learning
Electrode recordings and optogenetics reveal that the cerebellum can modulate its response to error signals from the brainstem during motor learning.
Rhea R Kimpo, Jacob M Rinaldi, Christina K Kim, Hannah L Payne, Jennifer L Raymond
Requirement for highly efficient pre-mRNA splicing during Drosophila early embryonic development
The need for efficient pre-RNA splicing during early embryonic development of Drosophila indicates that the constraints imposed by the cell cycle are a force capable of driving changes in Eukaryotic gene architecture.
Leonardo Gastón Guilgur, Pedro Prudêncio, Daniel Sobral, Denisa Liszekova, André Rosa, Rui Gonçalo Martinho
Regulation of branching dynamics by axon-intrinsic asymmetries in Tyrosine Kinase Receptor signaling
Asymmetric localization of the receptor EGFR within branches of axons is required to establish the precise wiring of neuronal networks within the Drosophila brain.
Marlen Zschätzsch, Carlos Oliva, Marion Langen, Natalie De Geest, Mehmet Neset Özel, W Ryan Williamson, William C Lemon, Alessia Soldano, Sebastian Munck, P Robin Hiesinger, Natalia Sanchez-Soriano, Bassem A Hassan
GE23077 binds to the RNA polymerase ‘i’ and ‘i+1’ sites and prevents the binding of initiating nucleotides
The cyclic-peptide antibiotic GE23077 inhibits bacterial RNA polymerase through a novel target that exhibits low susceptibility to target-based resistance and that enables synthesis of bipartite inhibitors that are exceptionally potent and refractory to target-based resistance.
Yu Zhang, David Degen, Mary X Ho, Elena Sineva, Katherine Y Ebright, Yon W Ebright, Vladimir Mekler, Hanif Vahedian-Movahed, Yu Feng, Ruiheng Yin, Steve Tuske, Herbert Irschik, Rolf Jansen, Sonia Maffioli, Stefano Donadio, Eddy Arnold, Richard H Ebright
Subcellular and supracellular mechanical stress prescribes cytoskeleton behavior in Arabidopsis cotyledon pavement cells
In the Arabidopsis epidermis, the internal mechanical stress of a cell competes with the external stress to control microtubule behavior, providing a framework to understand the mechanical feedbacks that underlie plant morphogenesis.
Arun Sampathkumar, Pawel Krupinski, Raymond Wightman, Pascale Milani, Alexandre Berquand, Arezki Boudaoud, Olivier Hamant, Henrik Jönsson, Elliot M Meyerowitz
The budding yeast Centromere DNA Element II wraps a stable Cse4 hemisome in either orientation in vivo
A stable tetrameric nucleosome occupies the central segment of each ∼120-bp budding yeast centromere in two rotational phases of both reflectional orientations in vivo.
Steven Henikoff, Srinivas Ramachandran, Kristina Krassovsky, Terri D Bryson, Christine A Codomo, Kristin Brogaard, Jonathan Widom, Ji-Ping Wang, Jorja G Henikoff
The nucleosomal barrier to promoter escape by RNA polymerase II is overcome by the chromatin remodeler Chd1
The ATP-dependent chromatin remodeler Chd1 controls nucleosome turnover to allow RNA Polymerase to transcribe in vivo.
Peter J Skene, Aaron E Hernandez, Mark Groudine, Steven Henikoff
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