Go to research articles
  1. Making the most of theta rhythms Read more
  2. SPECIAL SECTION
    Reproducibility and cancer biology
    Research Article
    Planar polarity:
    Long-range patterning gradients
    Insight
    Muscling in on the third dimension
    Insight
    Natural products:
    Exploring biosynthetic diversity
    Feature Article
    Living science:
    Bars and medals
    CAREERS
    Interview:
    Fanny Cazettes, New York

Latest research

  1. Cell biology
Regulation of EGFR signal transduction by analogue-to-digital conversion in endosomes
Cells package active receptors in endosomes at fairly constant amounts and can determine different cell-fate decisions by regulating the number and lifetime of receptor packages.
Roberto Villaseñor, Hidenori Nonaka, Perla Del Conte-Zerial, Yannis Kalaidzidis, Marino Zerial
Research article
|
  1. Human biology and medicine
  2. Microbiology and infectious disease
Mucosal effects of tenofovir 1% gel
Mucosal application of the anti-retroviral drug tenofovir, which is intended to prevent HIV transmission, has many off-target effects on the mucosa itself.
Florian Hladik, Adam Burgener, Lamar Ballweber, Raphael Gottardo, Lucia Vojtech, Slim Fourati, James Y Dai, Mark J Cameron, Johanna Strobl, Sean M Hughes, Craig Hoesley, Philip Andrew, Sherri Johnson, Jeanna Piper, David R Friend, T Blake Ball, Ross D Cranston, Kenneth H Mayer, M Juliana McElrath, Ian McGowan
Research article
|
  1. Neuroscience
CAPS-1 promotes fusion competence of stationary dense-core vesicles in presynaptic terminals of mammalian neurons
Stationary dense-core vesicles depend on the CAPS-1 protein to fuse with the presynaptic membrane.
Margherita Farina, Rhea van de Bospoort, Enqi He, Claudia M Persoon, Jan RT van Weering, Jurjen H Broeke, Matthijs Verhage, Ruud F Toonen
Research article
  1. Cell biology
  2. Neuroscience
The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly
Building on previous work which showed that the small molecule ISRIB potently blocks the integrated stress response (Sidrauski et al., 2013), we report on ISRIB's remarkable specificity and fast action in vivo, underscoring its proposed direct effect on translation.
Carmela Sidrauski, Anna M McGeachy, Nicholas T Ingolia, Peter Walter
Research advance
  1. Cell biology
  2. Developmental biology and stem cells
Regions within a single epidermal cell of Drosophila can be planar polarised independently
Building on previous work (Saaverda et al., 2014), we show that the Dachsous/Fat system can polarise different parts of a single cell in opposite ways in the Drosophila larva.
Miguel Rovira, Pedro Saavedra, José Casal, Peter A Lawrence
Research advance
|
  1. Cell biology
dPob/EMC is essential for biosynthesis of rhodopsin and other multi-pass membrane proteins in Drosophila photoreceptors
A membrane protein complex in the endoplasmic reticulum is a key factor for the biogenesis of multi-pass transmembrane proteins, including Rh1, and its loss causes retinal degeneration.
Takunori Satoh, Aya Ohba, Ziguang Liu, Tsuyoshi Inagaki, Akiko K Satoh
Research article
  1. Genomics and evolutionary biology
The genetic architecture of gene expression levels in wild baboons
RNA sequencing of individuals within a wild baboon population reveals extensive power to detect functional regulatory variation, and suggests that the set of genes affected by such variation may be conserved across species.
Jenny Tung, Xiang Zhou, Susan C Alberts, Matthew Stephens, Yoav Gilad
Research article
  1. Computational and systems biology
  2. Ecology
Expanding xylose metabolism in yeast for plant cell wall conversion to biofuels
Parallel pathways of xylose metabolism identified in fungi that grow on plants can be used in yeast to promote hemicellulose conversion to biofuels.
Xin Li, Vivian Yaci Yu, Yuping Lin, Kulika Chomvong, Raíssa Estrela, Annsea Park, Julie M Liang, Elizabeth A Znameroski, Joanna Feehan, Soo Rin Kim, Yong-Su Jin, N Louise Glass, Jamie HD Cate
Research article
|
  1. Developmental biology and stem cells
Cellular interpretation of the long-range gradient of Four-jointed activity in the Drosophila wing
Opposing gradients of Fat and Dachsous phosphorylation are sufficient to explain the observed pattern of Fat-Dachsous planar polarisation across the Drosophila wing.
Rosalind Hale, Amy L Brittle, Katherine H Fisher, Nicholas A M Monk, David Strutt
Research article
  1. Biophysics and structural biology
  2. Cell biology
Non-catalytic motor domains enable processive movement and functional diversification of the kinesin-14 Kar3
The kinesin-14 motor Kar3 moves along microtubules using a previously undescribed mechanism that critically requires the presence of a non-catalytic head.
Christine Mieck, Maxim I Molodtsov, Katarzyna Drzewicka, Babet van der Vaart, Gabriele Litos, Gerald Schmauss, Alipasha Vaziri, Stefan Westermann
Research article
|
More articles
Randy Schekman Editor-in-Chief, Nobel Prize winner 2013

Early in your career?

eLife editors want early-career scientists to thrive – to receive clear and constructive input on papers, quick decisions, and great exposure. In addition to pain-free peer review, we offer early-career scientists a letter of recommendation from one of our senior editors.

Read more about publishing with eLife