Research Articles

Research Articles published by eLife are full-length studies that present important breakthroughs across the life sciences and biomedicine. There is no maximum length and no limits on the number of display items.

Latest articles

    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Drosophila hamlet mediates epithelial tissue assembly of the reproductive system

    Huazhen Wang, Ludivine Bertonnier-Brouty ... Qi Dai
    Hamlet regulates heterotypic epithelial fusion by controlling spatial and temporal expression of known and novel epithelial regulators like Wnt and Tl pathway components, a mechanism potentially conserved through evolution.
    1. Neuroscience

    Cestode larvae excite host neuronal circuits via glutamatergic signalling

    Anja de Lange, Hayley Tomes ... Joseph V Raimondo
    Parasitic tapeworm larvae release glutamate and other excitatory molecules that can directly excite brain neurons.
    1. Plant Biology

    Competence for transcellular infection in the root cortex involves a post-replicative, cell-cycle exit decision in Medicago truncatula

    Morgane Batzenschlager, Beatrice Lace ... Thomas Ott
    Imaging deep root tissues with a combination of cell-cycle reporters reveals that a cortical cell file traversed by symbiotic bacteria exhibits reduced proliferative potential and enters a prolonged G2 phase.
    1. Neuroscience

    Multifaceted role of galanin in brain excitability

    Nicolas N Rieser, Milena Ronchetti ... Stephan CF Neuhauss
    The neuropeptide galanin modulates whole-brain activity and stress responses in zebrafish, revealing a complex, receptor-dependent role in seizure regulation with implications for epilepsy, and related neurological disorders.
    1. Neuroscience

    The interplay between homeostatic synaptic scaling and homeostatic structural plasticity maintains the robust firing rate of neural networks

    Han Lu, Sandra Diaz-Pier ... Andreas Vlachos
    A biphasic structural plasticity rule interacts with homeostatic synaptic scaling to maintain firing rate homeostasis in neural networks.
    1. Neuroscience
    2. Computational and Systems Biology

    Assemblies, synapse clustering, and network topology interact with plasticity to explain structure-function relationships of the cortical connectome

    András Ecker, Daniela Egas Santander ... Michael W Reimann
    A new framework for exploring the mechanisms underlying learning in cortical microcircuits is established.
    1. Neuroscience

    Intrinsic dynamic shapes responses to external stimulation in the human brain

    Maximilian Nentwich, Marcin Leszczynski ... Lucas C Parra
    A new computational model improves estimation of Granger connectivity by removing spurious effects of external inputs, and estimation of linear encoding models by removing spurious effects of recurrent connections.
    1. Immunology and Inflammation
    2. Medicine

    C-C chemokine receptor 4 deficiency exacerbates early atherosclerosis in mice

    Toru Tanaka, Naoto Sasaki ... Yoshiyuki Rikitake
    CCR4 expression in Tregs is critical for limiting proinflammatory Th1 cell-mediated immune responses and atherosclerosis by maintaining the suppressive and migratory functions of Tregs.
    1. Neuroscience
    2. Physics of Living Systems

    Responses to membrane potential-modulating ionic solutions measured by magnetic resonance imaging of cultured cells and in vivo rat cortex

    Kyeongseon Min, Sungkwon Chung ... Jang-Yeon Park
    Magnetic resonance imaging, through its sensitivity to ionic environments that modulate membrane potential, enables noninvasive assessment of biological systems.
    1. Neuroscience

    Elucidating the selection mechanisms in context-dependent computation through low-rank neural network modeling

    Yiteng Zhang, Jianfeng Feng, Bin Min
    Mechanistic modeling with low-rank recurrent networks uncovers the relationship between network connectivity, neural dynamics, and selection modulation mechanisms in context-dependent computation.
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