Death following traumatic brain injury in Drosophila is associated with intestinal barrier dysfunction
- University of Wisconsin-Madison, United States
Abstract
Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Unfavorable TBI outcomes result from primary mechanical injuries to the brain and ensuing secondary non-mechanical injuries that are not limited to the brain. Our Genome-wide Association study of Drosophila melanogaster revealed that the probability of death following TBI is associated with single nucleotide polymorphisms in genes involved in tissue barrier function and glucose homeostasis. We found that TBI causes intestinal and blood-brain barrier dysfunction and that intestinal barrier dysfunction is highly correlated with the probability of death. Furthermore, we found that ingestion of glucose after a primary injury increases the probability of death through a secondary injury mechanism that exacerbates intestinal barrier dysfunction. Our results indicate that natural variation in the probability of death following TBI is due in part to genetic differences that affect intestinal barrier dysfunction.
Article and author information
Author details
Reviewing Editor
- Utpal Banerjee, University of California, Los Angeles, United States
Version history
- Received: September 17, 2014
- Accepted: March 5, 2015
- Accepted Manuscript published: March 5, 2015 (version 1)
- Version of Record published: March 30, 2015 (version 2)
Copyright
© 2015, Katzenberger et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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Death following traumatic brain injury in Drosophila is associated with intestinal barrier dysfunction
eLife 4:e04790.
https://doi.org/10.7554/eLife.04790
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