1. Neuroscience

Propagated infra-slow intrinsic brain activity reorganizes across wake and slow wave sleep

  1. Anish Mitra  Is a corresponding author
  2. Abraham Z Snyder
  3. Enzo Tagliazucchi
  4. Helmut Laufs
  5. Marcus E Raichle
  1. Washington University in St. Louis, United States
  2. Christian-Albrechts-Universität zu Kiel, Germany
  3. Goethe-Universität Frankfurt am Main, Germany
https://doi.org/10.7554/eLife.10781
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  1. Anish Mitra
  2. Abraham Z Snyder
  3. Enzo Tagliazucchi
  4. Helmut Laufs
  5. Marcus E Raichle
(2015)
Propagated infra-slow intrinsic brain activity reorganizes across wake and slow wave sleep
eLife 4:e10781.
https://doi.org/10.7554/eLife.10781
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Abstract

Propagation of slow intrinsic brain activity has been widely observed in electrophysiogical studies of slow wave sleep (SWS). However, in human resting state fMRI (rs-fMRI), intrinsic activity has been understood predominantly in terms of zero-lag temporal synchrony (functional connectivity) within systems known as resting state networks (RSNs). Prior rs-fMRI studies have found that RSNs are generally preserved across wake and sleep. Here, we use a recently developed analysis technique to study propagation of infra-slow intrinsic blood oxygen level dependent (BOLD) signals in normal adults during wake and SWS. This analysis reveals marked changes in propagation patterns in SWS vs. wake. Broadly, ordered propagation is preserved within traditionally defined RSNs but lost between RSNs. Additionally, propagation between cerebral cortex and subcortical structures reverses directions, and intra-cortical propagation becomes reorganized, especially in visual and sensorimotor cortices. These findings show that propagated rs-fMRI activity informs theoretical accounts of the neural functions of sleep.

Article and author information

Author details

  1. Anish Mitra

    Department of Radiology, Washington University in St. Louis, St. Louis, United States
    For correspondence
    mikumusic@gmail.com
    Competing interests
    The authors declare that no competing interests exist.

  2. Abraham Z Snyder

    Department of Radiology, Washington University in St. Louis, St. Louis, United States
    Competing interests
    The authors declare that no competing interests exist.

  3. Enzo Tagliazucchi

    Institute for Medical Psychology, Christian-Albrechts-Universität zu Kiel, Kiel, Germany
    Competing interests
    The authors declare that no competing interests exist.

  4. Helmut Laufs

    Department of Neurology, Brain Imaging Center, Goethe-Universität Frankfurt am Main, Frankfurt, Germany
    Competing interests
    The authors declare that no competing interests exist.

  5. Marcus E Raichle

    Department of Radiology, Washington University in St. Louis, St. Louis, United States
    Competing interests
    The authors declare that no competing interests exist.

Reviewing Editor

  1. Heidi Johansen-Berg, University of Oxford, United Kingdom

Ethics

Human subjects: Written informed consent was obtained from all subjects whose data was analyzed in this study, and data collection for this study was approved by the Goethe University ethics committee.

Version history

  1. Received: August 11, 2015
  2. Accepted: November 6, 2015
  3. Accepted Manuscript published: November 9, 2015 (version 1)
  4. Version of Record published: January 20, 2016 (version 2)

Copyright

© 2015, Mitra et al.

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

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  1. Anish Mitra
  2. Abraham Z Snyder
  3. Enzo Tagliazucchi
  4. Helmut Laufs
  5. Marcus E Raichle
(2015)
Propagated infra-slow intrinsic brain activity reorganizes across wake and slow wave sleep
eLife 4:e10781.
https://doi.org/10.7554/eLife.10781

Share this article

https://doi.org/10.7554/eLife.10781

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