Cancer Biology

Latest articles

1. 1. Cancer Biology
   2. Medicine

   Monitoring circulating cell-free HPV DNA in metastatic or recurrent cervical cancer: clinical significance and treatment implications

   Zhuomin Yin, Tao Feng ... Hanmei Lou

   HPV cfDNA is a highly effective tumor marker for monitoring disease progression and treatment response in HPV-positive cervical cancer, offering valuable insights for guiding clinical decisions in precision medicine.
2. 1. Cancer Biology
   2. Computational and Systems Biology

   Altered thymic niche synergistically drives the massive proliferation of malignant thymocytes

   Erika Tsingos, Advaita M Dick, Baubak Bajoghli

   Combining computer modeling and experiments in animals shows that the spatial organization of thymic epithelial cells affects the availability of signaling molecules that regulate thymocyte proliferation and development.
3. 1. Cancer Biology

   SETD2 suppresses tumorigenesis in a KRAS^G12C-driven lung cancer model, and its catalytic activity is regulated by histone acetylation

   Ricardo J Mack, Natasha M Flores ... Or Gozani

   Genetic and biochemical studies show that SETD2 is tumor suppressive in a lung cancer mouse model and SETD2 methylation activity in vitro is regulated by histone acetylation.
4. 1. Cancer Biology

   KDM5 demethylases suppress R-loop-mediated “viral mimicry” and DNA damage in breast cancer cells

   Lena Lau, Kurt Henderson ... Marie Classon
5. 1. Cancer Biology
   2. Developmental Biology

   Dissecting infant leukemia developmental origins with a hemogenic gastruloid model

   Denise Ragusa, Chun Wai Suen ... Cristina Pina

   The hemogenic gastruloid model of embryonic blood development captures multi-wave haematopoiesis and enables interrogation of infant leukaemia cell-of-origin.
6. 1. Cancer Biology
   2. Immunology and Inflammation

   An evaluation of the tumor microenvironment through CALR, IL1R1, IFNB1, and IFNG to assess prognosis and immunotherapy response in bladder cancer patients

   Lilong Liu, Zhenghao Liu ... Zheng Liu

   A novel risk-scoring model enables personalized treatment decisions for bladder cancer patients.
7. 1. Cancer Biology
   2. Microbiology and Infectious Disease

   The long noncoding RNA lnc-FANCI-2 intrinsically restricts RAS signaling in human papillomavirus type 16-infected cervical cancer cells

   Haibin Liu, Lulu Yu ... Zhi-Ming Zheng

   A newly discovered long noncoding RNA lnc-FANCI-2 suppresses RAS signaling to modulate Akt and Erk1/2 phosphorylation in high-risk HPV cervical cancer, consequently regulating HPV carcinogenesis.
8. 1. Cancer Biology
   2. Physics of Living Systems

   Differential interfacial tension between oncogenic and wild-type populations forms the mechanical basis of tissue-specific oncogenesis in epithelia

   Amrapali Datta, Phanindra Dewan ... Medhavi Vishwakarma
9. 1. Cancer Biology
   2. Genetics and Genomics

   NAB2-STAT6 drives an EGR1-dependent neuroendocrine program in solitary fibrous tumors

   Connor Hill, Alexandra Indeglia ... Alessandro Gardini

   Molecular profiling with omics approaches reveals the resemblance between neuroendocrine malignancies and solitary fibrous tumors, rare soft tissue cancers with no effective treatment options.
10. 1. Cancer Biology

    NOLC1 suppresses immunochemotherapy by inhibiting p53-mediated ferroptosis in gastric cancer

    Shengsheng Zhao, Ji Lin ... Weijian Sun

    NOLC1 inhibits p53 nuclear accumulation and transcription, subsequently suppresses cisplatin-induced ferroptosis, and promotes an immunosuppressive microenvironment, eventually suppressing immunochemotherapy in gastric cancer.