Cancer Biology

Cancer Biology

eLife reviews research into cancer spanning from oncogenes and tumor suppressors to metastasis and anticancer treatments. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Immunology and Inflammation
    2. Cancer Biology

    Single-cell characterization of tumor immune landscapes in colorectal cancer humanized mice

    Sanne Bootsma, Job Saris ... Louis Vermeulen
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Cancer Biology

    Turning aging cells into a live vaccine: engineered senescent cancer cells with adjuvant celecoxib for immunotherapy

    Yuewei Wang, Ante Ou ... Yongzhuo Huang
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cancer Biology
    2. Genetics and Genomics

    Multimodal single-cell analyses reveal distinct fusion-regulated transcriptional programs in Ewing sarcoma

    Olivia G Waltner, April A Apfelbaum ... Scott N Furlan
    In Ewing sarcoma, a mesenchymal gene program normally repressed by the oncogenic fusion is reactivated by TGF-β signaling, and is associated with more aggressive disease.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Molidustat targets a synthetic lethal vulnerability in APC-mutant colorectal cancer through GSTP1 and PHD2 co-inhibition

    Chiara Asselborn, Agata N Makar ... Alex von Kriegsheim
    Simultaneous loss of GSTP1 and PHD2 activity is synthetically lethal in APC-mutant colorectal cells, driving cell-cycle arrest, metabolic collapse, and apoptosis.
    1. Immunology and Inflammation
    2. Cancer Biology

    Spatial Compartmentalization of TCR Repertoires Between Primary Melanomas and Sentinel Lymph Nodes Reveals Distinct Clonal Architectures and Shared Antigen Recognition

    Simo Kitanovski, Nalini Srinivas ... Jürgen C Becker
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Cancer Biology

    Targeting Polθ Helicase with RP-3467: Preclinical Validation and Clinical Response in a gBRCA1 ovarian cancer patient with an acquired PARPi resistance mutation in TP53BP1

    Ezra Y Rosen, Marie-Claude Mathieu ... Agnel Sfeir
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Targeting tankyrase scaffolding in the β-catenin destruction complex by PROTAC overcomes the limitation of catalytic inhibitors in colorectal cancer

    Qian Wang, Liping Li ... Chuo Chen
    Catalytic inhibition of tankyrase induces tankyrase accumulation and rigidifies the β-catenin destruction complex, limiting its ability to suppress WNT signaling.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Cancer cells differentially modulate mitochondrial respiration to alter redox state and enable biomass synthesis in nutrient-limited environments

    Sarah M Chang, Muhammad Bin Munim ... Matthew G Vander Heiden
    Examining the metabolic response of cancer cells to nutrient depletion reveals how the cell NAD+/NADH ratio can determine what nutrient environments are compatible with cancer cell proliferation.
    1. Cancer Biology

    Impacts of mutation accumulation and order on tumor initiation revealed by engineered murine colorectal cancer organoids

    Yanping Li, Xiaoxin Xie ... Qionghua Zhu
    The temporal order of driver mutations influences colorectal cancer initiation in an immune-dependent manner, highlighting tumor–immune interactions as a context for evolutionary selection.
    1. Computational and Systems Biology
    2. Cancer Biology

    Heterogeneous, population-level drug-tolerant persisters exhibit ion-channel remodeling and ferroptosis susceptibility

    Corey E Hayford, Blake Baleami ... Leonard A Harris
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
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Highlights

    1. Cancer Biology
    Image credit: coffeecurtains (CC0)

    Tumor Biology: The two faces of JAK-STAT

    Qianying Lu, Yingyi Zhang
    1. Cancer Biology
    2. Cell Biology

    Chemotherapy: Lipid balance and chemoresistance in cancer cells

    Kaori Kanemaru, Yoshikazu Nakamura
    1. Cancer Biology

    Breast Cancer: Slowing the growth of drug-resistant tumors

    Yingyi Zhang, Qianying Lu

Senior editors

  1. Yamini Dalal
    National Cancer Institute, United States
  2. Tony Ng
    King's College London, United Kingdom
  3. Lynne-Marie Postovit
    University of Alberta, Canada
  4. See more editors