Cancer Biology

Cancer Biology

eLife reviews research into cancer spanning from oncogenes and tumor suppressors to metastasis and anticancer treatments. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Cancer Biology

    Impacts of mutation accumulation and order on tumor initiation revealed by engineered murine colorectal cancer organoids

    Yanping Li, Xiaoxin Xie ... Qionghua Zhu
    The temporal order of driver mutations influences colorectal cancer initiation in an immune-dependent manner, highlighting tumor–immune interactions as a context for evolutionary selection.
    1. Computational and Systems Biology
    2. Cancer Biology

    Heterogeneous, population-level drug-tolerant persisters exhibit ion-channel remodeling and ferroptosis susceptibility

    Corey E Hayford, Blake Baleami ... Leonard A Harris
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cancer Biology
    2. Cell Biology

    Molecular and functional analysis of calcium binding by a cancer-linked calreticulin mutant

    Ishmael Nii Ayibontey Tagoe, Amanpreet Kaur ... Malini Raghavan
    Endoplasmic reticulum and cytosolic calcium levels, and store-operated calcium entry, are comparable in calreticulin-deficient cells rescued with either wild-type calreticulin or the myeloproliferative neoplasm-linked Del52 mutant.
    1. Cancer Biology

    An Itch Receptor Drives Melanoma

    Naina Gour, Aishwarya Atakkatan ... Xinzhong Dong
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Cancer Biology

    JAK-STAT pathway heterogeneity governs immunotherapy response in breast cancer

    Jianbo Zhou, Heng Zhang ... Fu Peng
    Multi-omics investigation identifies cell-type JAK-STAT heterogeneity as a predictive biomarker for PD-1 blockade in breast cancer.
    1. Cell Biology
    2. Cancer Biology

    P95-HER2 promotes metastatic progression by biasing MRTFA dependent signaling

    Joseph D Fernandes, Erin Bresnahan ... Joshua C Snyder
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cancer Biology
    2. Evolutionary Biology

    Punctuated mutagenesis promotes multi-step evolutionary adaptation in human cancers

    Christopher J Graser, Wenbo Wu ... Franziska Michor
    Evolutionary modeling reveals that punctuated bursts of mutations facilitate fitness-valley crossing in cancer, promoting multi-step adaptation across complex fitness landscapes.
    1. Cancer Biology

    IL1β/IL1R1/IRAK4 Drives Inflammatory Ovarian Cancer Seeding at the inflamed sites and Is Reversed by an IRAK4 inhibitor UR241-2

    John P Miller, Kyu Kwang Kim ... Rakesh K Singh
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Cancer Biology

    Microbial Metabolites Potentiate MAIT Cell Anti-Tumor Immunity Against Solid Tumors

    Yichen Zhu, Xinyuan Shen ... Lili Yang
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Computational and Systems Biology
    2. Cancer Biology

    MicroRNA spatial profiling for assessing drug efficacy in BRCA1-related triple-negative breast tumors

    Omar N Mohd, Lin Wang ... Patrick S Doyle
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
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Highlights

    1. Cancer Biology
    Image credit: coffeecurtains (CC0)

    Tumor Biology: The two faces of JAK-STAT

    Qianying Lu, Yingyi Zhang
    1. Cancer Biology
    2. Cell Biology

    Chemotherapy: Lipid balance and chemoresistance in cancer cells

    Kaori Kanemaru, Yoshikazu Nakamura
    1. Cancer Biology

    Breast Cancer: Slowing the growth of drug-resistant tumors

    Yingyi Zhang, Qianying Lu

Senior editors

  1. Eduardo Franco
    McGill University, Canada
  2. Tony Ng
    King's College London, United Kingdom
  3. Lynne-Marie Postovit
    University of Alberta, Canada
  4. See more editors