Biochemistry and Chemical Biology

Biochemistry and Chemical Biology

eLife reviews research that gives new insights into biological molecules or uses chemical approaches to illuminate complex biological processes. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Hundreds of myosin 10s are pushed to the tips of filopodia and could cause traffic jams on actin

    Julia Shangguan, Ronald S Rock
    Improved technology for counting proteins captures myosin 10 dynamics throughout the filopodial lifecycle, defines requirements for initiating filopodia, and reveals a crowded filopodial tip where motors frequently exceed available actin.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    The interplay between biomolecular assembly and phase separation

    Giacomo Bartolucci, Ivar S Haugerud ... Christoph A Weber
    Revised
    Reviewed Preprint v2 Updated
    1. Biochemistry and Chemical Biology

    Target protein identification in live cells and organisms with a non-diffusive proximity tagging system

    Yingjie Sun, Changheng Li ... Youngnam N Jin
    Not yet revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology

    Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning

    Gabriella O Estevam, Edmond M Linossi ... James S Fraser
    Not yet revised
    Reviewed Preprint v1
    1. Biochemistry and Chemical Biology

    A synthetic method to assay polycystin channel biophysics

    Megan Larmore, Orhi Esarte Palomero ... Paul G DeCaen
    Synthetic polycystin proteins self-assemble as function channels when reconstituted in lipid vesicles.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    One N-glycan regulates natural killer cell antibody-dependent cell-mediated cytotoxicity and modulates Fc γ receptor IIIa/CD16a structure

    Paul G Kremer, Elizabeth A Lampros ... Adam W Barb
    Multiple lines of evidence demonstrate that a single N-glycan on one receptor influences the strength of a cytotoxic response elicited by natural killer cells following stimulation with an antibody-coated target.
    1. Biochemistry and Chemical Biology

    A new class of receptors: Lipids regulate mammalian Gsα-stimulated adenylyl cyclase activities via their membrane anchors

    Marius Landau, Sherif Elsabbagh ... Joachim E Schultz
    Revised
    Reviewed Preprint v2 Updated
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    DYRK1A interacts with the tuberous sclerosis complex and promotes mTORC1 activity

    Pinhua Wang, Sunayana Sarkar ... Man Mohan
    DYRK1A, a kinase associated with intellectual developmental disorders and organ growth regulation, functions in cell growth by promoting mTORC1 activity.