A critical regulator of inhibitory neurotransmitter signaling in the hippocampus has been identified in experiments on mice and been shown to play essential role in synaptic plasticity and memory.
A protein called SIR-2.1 helps to protect worms from the effects of aging by regulating metabolic processes that would otherwise generate damaging reactive oxygen species.
Asymmetric localization of the receptor EGFR within branches of axons is required to establish the precise wiring of neuronal networks within the Drosophila brain.
MarlenZschätzsch, CarlosOliva, MarionLangen, NatalieDe Geest, Mehmet NesetÖzel, W RyanWilliamson, William CLemon, AlessiaSoldano, SebastianMunck, P RobinHiesinger, NataliaSanchez-Soriano, Bassem AHassan
Contrary to the common belief that cognitive event-related potentials are generated by local activity within the cerebral cortex, it is shown that some of these potentials are modulated by subcortical inputs.
No single molecular change is uniquely necessary to cause neuropathic changes in primary afferent excitability; multiple different changes are sufficient.
StéphanieRatté, YiZhu, Kwan YeopLee, Steven APrescott
In the brain at rest, the degree of coordinated activity within the motor network is inversely related to levels of the inhibitory transmitter GABA in primary motor cortex.
Charlotte JStagg, VeliciaBachtiar, UgwechiAmadi, Christel AGudberg, Andrei SIlie, CassandraSampaio-Baptista, JacintaO’Shea, MarkWoolrich, Stephen MSmith, NicolaFilippini, JamieNear, HeidiJohansen-Berg
As mice learn to associate events separated in time, neurons within the CA1 region of the hippocampus progressively reorganize their firing patterns, leading to a relay of cellular activity that bridges the two events.
