Chad W Sauvola, Yulia Akbergenova ... J Troy Littleton
Loss of the decoy SNARE Tomosyn enhances synaptic vesicle docking and neurotransmitter release and regulates release and plasticity differences between tonic and phasic motoneurons in Drosophila.
Dendritic calcium spikes translocate hippocampal place fields by inducing a non-Hebbian form of bidirectional synaptic plasticity that operates over a seconds-long timescale called behavioral timescale synaptic plasticity.
Conditional knockout of the small GTPase Cdc42 in excitatory neurons of the mouse forebrain leads to impaired long-term synaptic plasticity and impaired retrieval of remote memory.
Simple mathematical reasoning shows that the large amount of synaptic turnover seen in many parts of the brain is in fact optimal for memory retention.
Jakob Jordan, Maximilian Schmidt ... Mihai A Petrovici
Artificial evolution discovers biophysically plausible plasticity rules for spiking networks that perform competitively with and even outperform labor-intensive human-designed models in various learning scenarios, while providing new views on experimental data.
Three distinct AKT isoforms are found in the brain and show dissimilar patterns of expression, differential roles in the expression of synaptic plasticity, and different roles in neuronal signaling.