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    1. Structural Biology and Molecular Biophysics

    Lenacapavir-induced Lattice Hyperstabilization is Central to HIV-1 Capsid Failure at the Nuclear Pore Complex and in the Cytoplasm

    Arpa Hudait, Ryan C Burdick ... Gregory A Voth
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics
    2. Plant Biology

    Molecular dynamics simulations illuminate the role of sequence context in the ELF3-PrD-based temperature sensing mechanism in plants

    Richard J Lindsay, Abhilash Sahoo ... Sonya M Hanson
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    A novel RAB5 binding site in human VPS34-CII that is likely the primordial site in eukaryotic evolution

    Saule Spokaite, Yohei Ohashi ... Roger L Williams
    Cryo-EM structures unexpectedly show that there are two binding sites for RAB5, with the VPS15 site being the most evolutionarily ancient site, which is essential for endocytic sorting.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Effects of residue substitutions on the cellular abundance of proteins

    Thea K Schulze, Kresten Lindorff-Larsen
    Empirical substitution matrices from experimental measurements on 31,614 variants accurately predict cellular protein abundance changes using only amino-acid substitution and whether the site is buried or exposed.
    1. Structural Biology and Molecular Biophysics

    Two Glu/Asp Residues Cooperatively Mediate an Early Step of ATP Hydrolysis in GHKL ATPases MutL and GyrB

    Kenji Fukui, Ayaka Shibuya ... Takato Yano
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Structural Biology and Molecular Biophysics

    Twelve phosphomimetic mutations induce the assembly of recombinant full-length human tau into paired helical filaments

    Sofia Lövestam, Jane L Wagstaff ... Sjors HW Scheres
    Phosphomimetic mutations allow the assembly of full-length recombinant tau into Alzheimer's paired helical filaments by disrupting intramolecular contacts between its ordered core and fuzzy coat.
    1. Structural Biology and Molecular Biophysics

    ProteinConformers: large-scale and energetically profiled descriptions of protein conformational landscapes

    Yihang Zhou, Chen Wei ... Yang Zhang
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    Binding Entropy Can Be Predicted by Crystallographic Ensembles

    Charlotte A Miller, Stephanie A Wankowicz
    Not revised
    Reviewed Preprint v1
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    • Solid
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    ATP-driven conformational dynamics reveal hidden intermediates in a heterodimeric ABC transporter

    Matija Pečak, Christoph Nocker, Robert Tampé
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Structural Biology and Molecular Biophysics

    Intraflagellar transport protein IFT172 contains a C-terminal ubiquitin-binding U-box-like domain involved in ciliary signaling

    Nevin K Zacharia, Stefanie Kuhns ... Esben Lorentzen
    Revised
    Reviewed Preprint v2
    Updated
    • Important
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