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    1. Structural Biology and Molecular Biophysics

    The substrate-binding domains of the osmoregulatory ABC importer OpuA transiently interact

    Marco van den Noort, Panagiotis Drougkas ... Bert Poolman
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Microphase Separation Produces Interfacial Environment within Diblock Biomolecular Condensates

    Andrew P. Latham, Longchen Zhu ... Bin Zhang
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Effect of α-tubulin acetylation on the doublet microtubule structure

    Shun Kai Yang, Shintaroh Kubo ... Khanh Huy Bui
    Cryo-EM studies of doublet microtubules from wild-type and acetylation mutants suggest that acetylation of K40 affects the lateral rotational angle between protofilaments, leading to changes in the structure and stability.
    1. Structural Biology and Molecular Biophysics

    Structure-guided mutagenesis of OSCAs reveals differential activation to mechanical stimuli

    Sebastian Jojoa-Cruz, Adrienne E Dubin ... Andrew B Ward
    Structural comparison and electrophysiology of OSCA channels shed light on potential structural features influencing response to poke stimulus.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Interplay between charge distribution and DNA in shaping HP1 paralog phase separation and localization

    Tien M Phan, Young C Kim ... Jeetain Mittal
    Despite highly conserved sequences, subtle variations in HP1 paralog charge distribution influence distinct liquid-liquid phase separation behaviors, ultimately impacting DNA-mediated heterochromatin organization.
    1. Cancer Biology
    2. Structural Biology and Molecular Biophysics

    The molecular basis of Abelson kinase regulation by its αI-helix

    Johannes Paladini, Annalena Maier ... Stephan Grzesiek
    High-resolution NMR data and precise kinase activity assays on Abelson kinase bearing mutations in its αI-helix identify the αI-helix parts involved in disassembly of Abelson’s regulatory core and kinase activation.
    1. Structural Biology and Molecular Biophysics

    The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A

    Cristina Olivieri, Yingjie Wang ... Gianluigi Veglia
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Activity modulation in anaerobic ribonucleotide reductases: nucleotide binding to the ATP-cone allosterically mediates substrate binding to the active site

    Ornella Bimaï, Ipsita Banerjee ... Derek T. Logan
    1. Structural Biology and Molecular Biophysics

    Structural insights into the orthosteric inhibition of P2X receptors by non-ATP analog antagonists

    Danqi Sheng, Chen-Xi Yue ... Motoyuki Hattori
    Structural insights into the orthosteric inhibition and subtype specificity of P2X receptors by classical P2X antagonists facilitate the rational design of novel competitive antagonists for P2X receptors.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    C. elegans Dicer acts with the RIG-I-like helicase DRH-1 and RDE-4 to cleave dsRNA

    Claudia D. Consalvo, Adedeji M. Aderounmu ... Brenda L. Bass
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