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    1. Structural Biology and Molecular Biophysics

    Enhanced Processivity and Collective Force Production of Kinesins at Low Radial Forces

    Andrew M Hensley, Ahmet Yildiz
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Roles of the membrane-binding motif and the C-terminal domain of RNase E in localization and diffusion in E. coli

    Laura Troyer, Yu-Huan Wang ... Sangjin Kim
    Single-molecule imaging uncovers how distinct membrane-binding motifs and the intrinsically disordered C-terminal domain control RNase E’s membrane association and diffusion, linking structural divergence to RNA-processing dynamics in bacteria.
    1. Structural Biology and Molecular Biophysics

    Insights from aquaporin structures into drug-resistant sleeping sickness

    Modestas Matusevicius, Robin A Corey ... Simone N Weyand
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Characterization of binding kinetics and intracellular signaling of new psychoactive substances targeting cannabinoid receptor using transition-based reweighting method

    Soumajit Dutta, Diwakar Shukla
    New psychoactive substances activate cannabinoid receptors using distinct ligand-receptor interactions.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Unbend: Correction of local beam-induced sample motion in cryo-EM images using a 3D spline model

    Lingli Kong, Ximena Zottig ... Nikolaus Grigorieff
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Accessibility of the unstructured α-tubulin C-terminal tail is controlled by microtubule lattice conformation

    Takashi Hotta, Morgan L Pimm ... Kristen J Verhey
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Compound Mutations in the Abl1 Kinase Cause Inhibitor Resistance by Shifting DFG Flip Mechanisms and Relative State Populations

    Gabriel Monteiro da Silva, Kyle Lam ... Brenda M Rubenstein
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Functionally-Coupled Ion Channels Begin Co-assembling at the Start of Their Synthesis

    Roya Pournejati, Jessica M Huang ... Oscar Vivas
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Cryo-electron tomography reveals the microtubule-bound form of inactive LRRK2

    Siyu Chen, Tamar Basiashvili ... Elizabeth Villa
    Full-length, autoinhibited LRRK2 assembles into distinct, shorter microtubule-bound filaments via a previously unobserved N-terminal repeat interface, revealing new structural states with potential therapeutic implications.
    Version of Record
    Short Report
    • Important
    • Convincing
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    Cryo-EM Reveals Regulatory Mechanisms Governing Substrate Selection and Activation of Human LONP1

    Jeffrey T Mindrebo, Lauren Alexandrescu ... Gabriel C Lander
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
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