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    1. Structural Biology and Molecular Biophysics

    Active regulation of the epidermal growth factor receptor by the membrane bilayer

    Shwetha Srinivasan, Xingcheng Lin ... Gabriela S Schlau-Cohen
    Membrane composition modulates EGFR conformational dynamics and signaling, revealing that the bilayer properties can override ligand control to influence receptor activation in health and disease.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Gβγ engages PLCβ3 at multiple sites to reorient and facilitate its activation

    Isaac J Fisher, Kanishka Senarath ... Angeline M Lyon
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Natural xanthones as α-Mangostin induce vasorelaxation involving key gating residues in the S6 domain of BK channels

    Sönke Cordeiro, Robert Patejdl ... Marianne Musinszki
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
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    1. Structural Biology and Molecular Biophysics

    Glycobiology: How enzymes make the right choice during biosynthesis

    Ana S Ramírez, Camilo Perez
    The biosynthesis of an important biopolymer called hyaluronan requires an enzyme that discriminates between two different substrates.
    Version of Record
    Insight
    1. Structural Biology and Molecular Biophysics

    A structural code for assembly specificity in GID/CTLH-type E3 ligases

    Pia Maria van gen Hassend, Hermann Schindelin
    Structural characterization of the CTLH-CRA domain-mediated pairing in the CTLH ubiquitin ligase complex enables rational engineering of interfaces with altered binding specificity.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Unbend: Correction of local beam-induced sample motion in cryo-EM images using a 3D spline model

    Lingli Kong, Ximena Zottig ... Nikolaus Grigorieff
    Revised
    Reviewed Preprint v2
    Updated
    • Important
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    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Detecting directed motion and confinement in single-particle trajectories using hidden variables

    François Simon, Guillaume Ramadier ... Lucien E Weiss
    Exatrack is a framework for analyzing Brownian, directed, and confined motion using a hidden-variable probabilistic model to extract physical insight into particle diffusion.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Transforming a fragile protein helix into an ultrastable scaffold via a hierarchical AI and chemistry framework

    Jun Qiu, Guojin Tang ... Peng Zheng
    A hierarchical framework integrating artificial intelligence with chemical principles enables the conversion of fragile α-helices into ultrastable protein scaffolds.
    1. Structural Biology and Molecular Biophysics

    Membrane Biology: Two binding sites are better than one

    Mackenzie K Scott, John E Burke
    The reasons why two multiprotein complexes – VPS34 complex I and VPS34 complex II – are activated by different Rab proteins are becoming clearer.
    Version of Record
    Insight
    1. Structural Biology and Molecular Biophysics

    A novel RAB5 binding site in human VPS34-CII that is likely the primordial site in eukaryotic evolution

    Saulė Špokaitė, Yohei Ohashi ... Roger L Williams
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
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