Pvr expression regulators in equilibrium signal control and maintenance of Drosophila blood progenitors

  1. Bama Charan Mondal
  2. Jiwon Shim
  3. Cory J Evans
  4. Utpal Banerjee  Is a corresponding author
  1. University of California, Los Angeles, United States
  2. Hanyang University, Republic of Korea

Abstract

Blood progenitors within the lymph gland, a larval organ that supports hematopoiesis in Drosophila melanogaster, are maintained by integrating signals emanating from niche-like cells and those from differentiating blood cells. We term the signal from differentiating cells the 'equilibrium signal' in order to distinguish it from the 'niche signal'. Earlier we showed that Equilibrium signaling utilizes Pvr (the Drosophila PDGF/VEGF receptor), STAT92E, and Adenosine deaminase-related growth factor A (ADGF-A) [1]. Little is known about how this signal initiates during hematopoietic development. To identify new genes involved in lymph gland blood progenitor maintenance, particularly those involved in equilibrium signaling, we performed a genetic screen that identified bip1 (bric à brac interacting protein 1) and Nucleoporin 98 (Nup98) as additional regulators of the equilibrium signal. We show that the products of these genes along with the Bip1-interacting protein RpS8 (Ribosomal protein S8) are required for the proper expression of Pvr.

Article and author information

Author details

  1. Bama Charan Mondal

    University of California, Los Angeles, Los Angeles, United States
    Competing interests
    No competing interests declared.
  2. Jiwon Shim

    Hanyang University, Seoul, Republic of Korea
    Competing interests
    No competing interests declared.
  3. Cory J Evans

    University of California, Los Angeles, Los Angeles, United States
    Competing interests
    No competing interests declared.
  4. Utpal Banerjee

    University of California, Los Angeles, Los Angeles, United States
    For correspondence
    banerjee@mbi.ucla.edu
    Competing interests
    Utpal Banerjee, Reviewing editor, eLife.

Reviewing Editor

  1. Benjamin Ohlstein, Columbia University Medical Center, United States

Version history

  1. Received: June 7, 2014
  2. Accepted: September 5, 2014
  3. Accepted Manuscript published: September 8, 2014 (version 1)
  4. Version of Record published: October 6, 2014 (version 2)

Copyright

© 2014, Mondal et al.

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

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  1. Bama Charan Mondal
  2. Jiwon Shim
  3. Cory J Evans
  4. Utpal Banerjee
(2014)
Pvr expression regulators in equilibrium signal control and maintenance of Drosophila blood progenitors
eLife 3:e03626.
https://doi.org/10.7554/eLife.03626

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https://doi.org/10.7554/eLife.03626

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