Highlights

Latest research

    1. Ecology
    2. Physics of Living Systems

    Evidence of social learning across symbolic cultural barriers in sperm whales

    Antonio Leitao, Maxime Lucas ... Giovanni Petri
    1. Neuroscience

    Neuron-specific RNA-sequencing reveals different responses in peripheral neurons after nerve injury

    Sara Bolívar, Elisenda Sanz ... Esther Udina
    In reporter mice, subtypes of peripheral neurons show different regenerative capabilities after nerve injury and activate common pathways but also specific ones, indicating a different intrinsic growth response among them.
    1. Computational and Systems Biology

    Phantasus, a web-application for visual and interactive gene expression analysis

    Maksim Kleverov, Daria Zenkova ... Alexey A Sergushichev
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Allosteric coupling asymmetry mediates paradoxical activation of BRAF by type II inhibitors

    Damien M Rasmussen, Manny M Semonis ... Nicholas M Levinson
    A comprehensive allosteric model describes how inhibitors can activate rather than inhibit a target kinase by selectively driving formation of kinase dimers with one inhibited and one activated subunit.
    1. Cell Biology
    2. Neuroscience

    Unraveling the link between neuropathy target esterase NTE/SWS, lysosomal storage diseases, inflammation, abnormal fatty acid metabolism, and leaky brain barrier

    Mariana I Tsap, Andriy S Yatsenko ... Halyna R Shcherbata
    Drosophila model reveals that NTE/SWS-associated neurodegeneration is a lysosomal storage disorder accompanied by a leaky brain permeability barrier, abnormal fatty acid metabolism, and inflammation.
    1. Stem Cells and Regenerative Medicine

    Compositional editing of extracellular matrices by CRISPR/Cas9 engineering of human mesenchymal stem cell lines

    Sujeethkumar Prithiviraj, Alejandro Garcia Garcia ... Paul E Bourgine