Genes and chromosomes

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A previously unappreciated histone methylation pathway helps limit DNA double-strand break formation and recombination in heterochromatin during meiosis.
Romeo Papazyan, Ekaterina Voronina, Jessica R Chapman, Teresa R Luperchio, Tonya M Gilbert, Elizabeth Meier, Samuel G Mackintosh, Jeffrey Shabanowitz, Alan J Tackett, Karen L Reddy, Robert S Coyne, Donald F Hunt, Yifan Liu, Sean D Taverna
10.7554/eLife.02996
We discuss the methods available to understand lncRNA function in vivo, and highlight important considerations that should be taken into account when designing such experiments.
Andrew R Bassett, Asifa Akhtar, Denise P Barlow, Adrian P Bird, Neil Brockdorff, Denis Duboule, Anne Ephrussi, Anne C Ferguson-Smith, Thomas R Gingeras, Wilfried Haerty, Douglas R Higgs, Eric A Miska, Chris P Ponting
10.7554/eLife.03058.007
We discuss the methods available to understand lncRNA function in vivo, and highlight important considerations that should be taken into account when designing such experiments.
Andrew R Bassett, Asifa Akhtar, Denise P Barlow, Adrian P Bird, Neil Brockdorff, Denis Duboule, Anne Ephrussi, Anne C Ferguson-Smith, Thomas R Gingeras, Wilfried Haerty, Douglas R Higgs, Eric A Miska, Chris P Ponting
10.7554/eLife.03058
Segment-specific boundaries of histone modifications reveal the regulatory logic of a classic developmental control region.
Sarah K Bowman, Aimee M Deaton, Heber Domingues, Peggy I Wang, Ruslan I Sadreyev, Robert E Kingston, Welcome Bender
10.7554/eLife.02833
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Aneuploidy produces a protein expression signature characteristic of altered metabolism and redox homeostasis, and the loss of UBP6 ameliorates several aneuploidy-associated phenotypes.
Noah Dephoure, Sunyoung Hwang, Ciara O'Sullivan, Stacie E Dodgson, Steven P Gygi, Angelika Amon, Eduardo M Torres
10.7554/eLife.03023
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