Genes and chromosomes

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We discuss the methods available to understand lncRNA function in vivo, and highlight important considerations that should be taken into account when designing such experiments.
Andrew R Bassett, Asifa Akhtar, Denise P Barlow, Adrian P Bird, Neil Brockdorff, Denis Duboule, Anne Ephrussi, Anne C Ferguson-Smith, Thomas R Gingeras, Wilfried Haerty, Douglas R Higgs, Eric A Miska, Chris P Ponting
10.7554/eLife.03058.007
We discuss the methods available to understand lncRNA function in vivo, and highlight important considerations that should be taken into account when designing such experiments.
Andrew R Bassett, Asifa Akhtar, Denise P Barlow, Adrian P Bird, Neil Brockdorff, Denis Duboule, Anne Ephrussi, Anne C Ferguson-Smith, Thomas R Gingeras, Wilfried Haerty, Douglas R Higgs, Eric A Miska, Chris P Ponting
10.7554/eLife.03058
Segment-specific boundaries of histone modifications reveal the regulatory logic of a classic developmental control region.
Sarah K Bowman, Aimee M Deaton, Heber Domingues, Peggy I Wang, Ruslan I Sadreyev, Robert E Kingston, Welcome Bender
10.7554/eLife.02833
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Aneuploidy produces a protein expression signature characteristic of altered metabolism and redox homeostasis, and the loss of UBP6 ameliorates several aneuploidy-associated phenotypes.
Noah Dephoure, Sunyoung Hwang, Ciara O'Sullivan, Stacie E Dodgson, Steven P Gygi, Angelika Amon, Eduardo M Torres
10.7554/eLife.03023
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Combining CRISPR/Cas9 genome editing with gene drives may enable scientists to reversibly edit the genomes of diverse wild populations, an advance that could help eliminate diseases, support sustainable agriculture, and control invasive species.
Kevin M Esvelt, Andrea L Smidler, Flaminia Catteruccia, George M Church
10.7554/eLife.03401
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Showing results 1 - 10 of 96