Genetics and Genomics

Genetics and Genomics

eLife reviews research including the genetic basis of health and disease, epigenetics, genomics, medical genetics, genetic epidemiology, and population genetics. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Genetics and Genomics
    2. Immunology and Inflammation

    Host Endoplasmic Reticulum Stress and Interferon Responses Contribute to AAV-Induced Ocular Toxicity

    Apolonia Gardner, Christin Hong ... Constance L Cepko
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    1. Genetics and Genomics
    2. Medicine

    Translational reading frame determines the pathogenicity of C-terminal frameshift deletions in MeCP2: an alternative therapeutic approach

    Jacky Guy, Elena Hein ... Adrian Bird
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics

    Fourfold lifespan extension in C. elegans daf-2 mutant males

    Mike Russell, Michelle Lin ... Liou Y Sun
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Genetics and Genomics
    2. Medicine

    Single-cell transcriptome-wide Mendelian randomization and colocalization analyses reveal immune-cell-specific mechanisms and actionable drug targets in prostate cancer

    Yanggang Hong, Yi Wang ... Jiajun Li
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Genetics and Genomics

    Autosomal allelic inactivation at loci with variable replication timing and dosage sensitivity

    Michael B Heskett, Athanasios E Vouzas ... Mathew J Thayer
    Stable allele-specific epigenetic regulation creates cellular mosaicism of numerous autosomal dosage-sensitive genes involved in human neurological and developmental disorders.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Pervasive relaxed selection on spermatogenesis genes coincident with the evolution of polygyny in gorillas

    Jacob D Bowman, Neide Silva ... Vincent J Lynch
    Genes associated with male reproductive biology appear to be under relaxed selective constraint in a primate species with low sperm competition.
    1. Genetics and Genomics

    Optimised genome editing for precise DNA insertion and substitution using prime editors in zebrafish

    Yosuke Ono, Martin Peterka ... Steffen Scholpp
    Nickase and nuclease Prime Editors offer complementary routes for precise zebrafish genome editing, balancing accuracy for substitutions with efficiency for short insertions.
    1. Cell Biology
    2. Genetics and Genomics

    Cytosolic Carboxypeptidase 5 maintains mammalian ependymal multicilia to ensure proper homeostasis and functions of the brain

    Rubina Dad, Yujuan Wang ... Hui-Yuan Wu
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Cell Biology
    2. Genetics and Genomics

    Mechanistic insights into transcriptional regulation of ARHGAP36 expression identify a factor predictive of neuroblastoma survival

    Serhiy Havrylov, Armin M Gamper, Ordan J Lehmann
    Genetic experiments integrated with ChIP-sequencing and CRISPR interference reveal that overexpression of Foxc1 transcriptionally activates the expression of Arhgap36 and dysregulates multiple facets of Hedgehog pathway activity.
    1. Developmental Biology
    2. Genetics and Genomics

    Flexible and high-throughput simultaneous profiling of gene expression and chromatin accessibility in single cells

    Volker Soltys, Moritz Peters ... Yingguang Frank Chan
    Revised
    Reviewed Preprint v3
    Updated
    • Useful
    • Solid
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Highlights

    1. Genetics and Genomics
    2. Medicine

    Responding to peer reviewers

    Eric Kalkhoven, Manon Kluijtmans
    1. Developmental Biology
    2. Genetics and Genomics

    Written out of history

    Lisa M Thomann, Julie Batut
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Chromosomes: Finding a role for non-coding DNA in trypanosomes

    Markus R Schmidt

Senior editors

  1. Kathryn Cheah
    The University of Hong Kong, Hong Kong SAR China
  2. Alan Moses
    University of Toronto, Canada
  3. Wei Yan
    Washington State University, United States
  4. See more editors