Genetics and Genomics

Genetics and Genomics

eLife reviews research including the genetic basis of health and disease, epigenetics, genomics, medical genetics, genetic epidemiology, and population genetics. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Genetics and Genomics
    2. Evolutionary Biology

    Cross-Kingdom Control: Yeast Prion Protein [MRPL10+] Modulates Host Physiology in Drosophila

    Chih-Chun Janet Lin, Jessica Y Jiang ... Andrew G Clark
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Separable downmodulation of meiotic axis protein deposition and DNA break induction at chromosome ends

    Adhithi R Raghavan, Kieron May ... Andreas Hochwagen
    Meiotic axis protein deposition and double-strand break formation near yeast chromosome ends are regulated by multiple distinct layers of regulation, including the chromatin modifiers Sir2/3 and Dot1.
    1. Genetics and Genomics
    2. Physiology

    RiboTRAP-seq identifies spatially distinct functions for the anterior and posterior intestine in immune and metabolic regulation in Caenorhabditis elegans

    Chung-Chih Liu, Nicolas Seban, Supriya Srinivasan
    Specialized anterior intestinal cells in Caenorhabditis elegans act as sentinels, regulating pathogen responses and linking food availability to gut peptide secretion through pyruvate metabolism.
    1. Genetics and Genomics
    2. Evolutionary Biology

    Phylogenomics of free-living neobodonids reveals they are a paraphyletic group from which all other metakinetoplastids are descended

    Daryna Zavadska, Julia A Packer ... Daniel J Richter
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Zebrafish Rif1 impacts zygotic genome activation, replication timing, and sex determination

    Emily A Masser, Tyler D Noble ... Christopher L Sansam
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Gene function and expression profiling in yeast spores, killifish diapause embryos, and their post-dormant offspring cells

    Shaimaa Hassan, Maria Rodriguez-López ... Jürg Bähler
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Genetics and Genomics
    2. Plant Biology

    AT-HOOK-MOTIF NUCLEAR LOCALIZED 15 extends plant longevity by binding at poorly accessible, epigenetic mark-depleted chromatin surrounding transcribed regions

    Thalia Luden, Jihed Chouaref, Remko Offringa
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Neuroscience

    Starvation transforms signal encoding in C. elegans thermoresponsive neurons and suppresses heat avoidance via bidirectional glutamatergic and peptidergic signaling

    Saurabh Thapliyal, Parvathi Sushama Gopinath, Dominique A Glauser
    Nutritional state dynamically reshapes sensory processing to prioritize behavioral responses, revealing the plastic coupling of sensation, internal state, and behavior.
    1. Genetics and Genomics

    Replicability of Scientific Claims in Drosophila Immunity: A Retrospective Analysis of 400 Publications

    Hannah Westlake, Fabrice David ... Bruno Lemaitre
    Revised
    Reviewed Preprint v2
    Updated
    • Landmark
    • Convincing
    1. Genetics and Genomics

    A retrospective analysis of 400 publications reveals patterns of irreplicability across an entire life sciences research field

    Joseph Lemaitre, Désirée Popelka ... Bruno Lemaitre
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
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Highlights

    1. Genetics and Genomics
    Microscopy image of a fruit fly. Image credit: USGS (CC0)

    How experience shapes individuality

    Bassem A Hassan
    1. Genetics and Genomics
    2. Medicine

    Responding to peer reviewers

    Eric Kalkhoven, Manon Kluijtmans
    1. Developmental Biology
    2. Genetics and Genomics

    Written out of history

    Lisa M Thomann, Julie Batut

Senior editors

  1. Murim Choi
    Seoul National University College of Medicine, South Korea
  2. Yamini Dalal
    National Cancer Institute, United States
  3. Adèle L Marston
    University of Edinburgh, United Kingdom
  4. See more editors