Genetics and Genomics

Latest articles

1. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   Chromosomes: Finding a role for non-coding DNA in trypanosomes

   Markus R Schmidt

   Non-coding DNA is essential for both humans and trypanosomes, despite the large evolutionary divergence between these two species.
2. 1. Genetics and Genomics

   Khdc3 Regulates Metabolism Across Generations in a DNA-Independent Manner

   Liana Senaldi, Nora Hassan ... Matthew Smith-Raska
3. 1. Developmental Biology
   2. Genetics and Genomics

   In situ mutational screening and CRISPR interference reveal that the apterous Early enhancer is required for developmental boundary positioning

   Gustavo Aguilar, Michèle Sickmann ... Martin Müller
4. 1. Genetics and Genomics

   The Impact of Stability Considerations on Genetic Fine-mapping

   Alan J Aw, Lionel Chentian Jin ... Yun S Song
5. 1. Cell Biology
   2. Genetics and Genomics

   Cross-species evaluation of TANGO2 homologs, including HRG-9 and HRG-10 in Caenorhabditis elegans, challenges a proposed role in heme trafficking

   Sarah E Sandkuhler, Kayla S Youngs ... Samuel J Mackenzie

   Evidence from multiple model systems supports a shift away from heme transport and toward metabolic dysfunction and oxidative stress as key drivers of TANGO2 deficiency.
6. 1. Genetics and Genomics
   2. Physics of Living Systems

   Raman Spectroscopy: Probing the proteome

   Wei-Hsiang Lin, Chia-Liang Cheng

   Raman spectroscopy can be used to predict cellular physiology and proteome composition in E. coli.
7. 1. Cancer Biology
   2. Genetics and Genomics

   Replication stress-inducing ELF3 upregulation promotes BRCA1-deficient breast tumorigenesis in luminal progenitors

   Jiadong Zhou, Xiao Albert Zhou ... Jiadong Wang

   A replication stress–ELF3 axis enables luminal progenitor transformation in BRCA1-deficient breast cancer by reducing genomic instability and promoting progenitor identity.
8. 1. Genetics and Genomics
   2. Neuroscience

   Integrating bulk and single cell RNA-seq refines transcriptomic profiles of individual C. elegans neurons

   Alec Barrett, Erdem Varol ... Marc Hammarlund
9. 1. Genetics and Genomics

   A default silencing mechanism restrains stress-induced genes in C. elegans

   Orkan Ilbay, Alejandro Rodriguez Gama ... Andrew Fire
10. 1. Genetics and Genomics
    2. Neuroscience

    Opioid Use Disorder: Identifying new targets in the fight against opioids

    Fernanda Laezza

    Experiments reveal that a time-dependent epistatic interaction influences how mice respond to opioids, and that intracellular fibroblast growth factors also influence opioid sensitivity.