Genetics and Genomics

Genetics and Genomics

eLife reviews research including the genetic basis of health and disease, epigenetics, genomics, medical genetics, genetic epidemiology, and population genetics. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Genetics and Genomics

    Scale dependence decouple life history traits from transposable element evolution in sauropsids

    Yun Liang, Bin Zuo, Yan-Bo Sun
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Genetics and Genomics
    2. Physiology

    Steroid Signaling: A hormonal message for a longer life

    Kyle Feola, Peter M Douglas
    The steroid hormone dafachronic acid may carry the effects of reduced mTOR activity between tissues to coordinate metabolism and longevity across the body.
    Version of Record
    Insight
    1. Genetics and Genomics
    2. Immunology and Inflammation

    GM-CSF regulates conserved ILC-like transcriptional states and myeloid cell signaling during ulceration in Crohn’s disease

    Joshua K Morrison, Ksenija Sabic ... Ling-shiang Chuang
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Cell Biology
    2. Genetics and Genomics

    Effects of knockdown of autophagy pathway genes on C. elegans longevity are highly condition dependent

    Kuei Ching Hsiung, Hannah Chapman ... David Gems
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    1. Genetics and Genomics
    2. Evolutionary Biology

    Cross-Kingdom Control: Yeast Prion Protein [MRPL10+] Modulates Host Physiology in Drosophila

    Chih-Chun Janet Lin, Jessica Y Jiang ... Andrew G Clark
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Separable downmodulation of meiotic axis protein deposition and DNA break induction at chromosome ends

    Adhithi R Raghavan, Kieron May ... Andreas Hochwagen
    Meiotic axis protein deposition and double-strand break formation near yeast chromosome ends are regulated by multiple distinct layers of regulation, including the chromatin modifiers Sir2/3 and Dot1.
    1. Genetics and Genomics
    2. Physiology

    RiboTRAP-seq identifies spatially distinct functions for the anterior and posterior intestine in immune and metabolic regulation in Caenorhabditis elegans

    Chung-Chih Liu, Nicolas Seban, Supriya Srinivasan
    Specialized anterior intestinal cells in Caenorhabditis elegans act as sentinels, regulating pathogen responses and linking food availability to gut peptide secretion through pyruvate metabolism.
    1. Genetics and Genomics
    2. Evolutionary Biology

    Phylogenomics of free-living neobodonids reveals they are a paraphyletic group from which all other metakinetoplastids are descended

    Daryna Zavadska, Julia A Packer ... Daniel J Richter
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Zebrafish Rif1 impacts zygotic genome activation, replication timing, and sex determination

    Emily A Masser, Tyler D Noble ... Christopher L Sansam
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Gene function and expression profiling in yeast spores, killifish diapause embryos, and their post-dormant offspring cells

    Shaimaa Hassan, Maria Rodriguez-López ... Jürg Bähler
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
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Highlights

    1. Genetics and Genomics
    Microscopy image of a fruit fly. Image credit: USGS (CC0)

    How experience shapes individuality

    Bassem A Hassan
    1. Genetics and Genomics
    2. Medicine

    Responding to peer reviewers

    Eric Kalkhoven, Manon Kluijtmans
    1. Developmental Biology
    2. Genetics and Genomics

    Written out of history

    Lisa M Thomann, Julie Batut

Senior editors

  1. Kathryn Cheah
    The University of Hong Kong, Hong Kong SAR China
  2. Murim Choi
    Seoul National University College of Medicine, South Korea
  3. Alan Moses
    University of Toronto, Canada
  4. See more editors