Genetics and Genomics

Latest articles

1. 1. Genetics and Genomics

   Autosomal Allelic Inactivation: Variable Replication and Dosage Sensitivity

   Michael B Heskett, Athanasios E Vouzas ... Mathew J Thayer
2. 1. Genetics and Genomics
   2. Evolutionary Biology

   Constraints on the G1/S transition pathway may favor selection of multicellularity as a passenger phenotype

   Tom Louis Ducrocq, Damien Laporte, Bertrand Daignan-Fornier
3. 1. Computational and Systems Biology
   2. Genetics and Genomics

   JAX Animal Behavior System (JABS), a genetics-informed, end-to-end advanced behavioral phenotyping platform for the laboratory mouse

   Anshul Choudhary, Brian Q Geuther ... Vivek Kumar

   The JAX Animal Behavior System integrates standardized hardware, machine learning methods, and annotated datasets to enable reproducible behavioral phenotyping and genetic analysis across diverse mouse strains.
4. 1. Genetics and Genomics

   Mettl5 coordinates protein production and degradation of PERIOD to regulate sleep in Drosophila

   Xiaoyu Wu, Xingzhuo Yang ... Juan Du
5. 1. Cell Biology
   2. Genetics and Genomics

   Non-visual light modulates behavioral memory and gene expression in Caenorhabditis elegans

   Zhijian Ji, Bingying Wang ... Dengke K Ma

   Visible light engages a non-visual, bZIP-dependent transcriptional pathway in peripheral tissues that communicates with the nervous system to shape behavioral plasticity and memory, enabling optogenetic-like gene control without photoreceptors.
6. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   Virus Evolution: Scaling up efforts to target evolving viruses

   Lin Wang, Henrik Salje

   High-throughput neutralisation tests could lead to a better understanding of the evolution of human influenza.
7. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   Transition of Staphylococcus aureus tetracycline resistance plasmid pT181 from independent multicopy replicon to predominantly integrated chromosomal element over 65 years

   Megan A Phillips, Robert A Petit ... Timothy D Read
8. 1. Genetics and Genomics
   2. Neuroscience

   Impaired excitability of fast-spiking neurons in a novel mouse model of KCNC1 epileptic encephalopathy

   Eric R Wengert, Sophie R Liebergall ... Ethan M Goldberg

   Brain slice electrophysiology, immunohistochemistry, and in vivo two-photon calcium imaging identify circuit dysfunction and epilepsy mechanism in a Kcnc1-A421V/+ mouse model of developmental and epileptic encephalopathy.
9. 1. Biochemistry and Chemical Biology
   2. Genetics and Genomics

   Determining the off-target activity of antibiotics and novel translation initiation sites in mitochondria

   James Marks, Emma Young, Markus Hafner
10. 1. Genetics and Genomics

    SETDB1 enables development beyond cleavage stages by extinguishing the MERVL-driven two-cell totipotency transcriptional program in the mouse embryo

    Tie-Bo Zeng, Zhen Fu ... Piroska E Szabó

    Conditional genetics and single-embryo RNA-seq show that SETDB1 extinguishes the transient, retroelement-driven transcriptional programs of the totipotent two-cell state to facilitate the exit from totipotency and ensure preimplantation development.