Genetics and Genomics

Genetics and Genomics

eLife reviews research including the genetic basis of health and disease, epigenetics, genomics, medical genetics, genetic epidemiology, and population genetics. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Genetics and Genomics
    2. Evolutionary Biology

    Genome-wide architecture of prolonged starvation adaptation in experimentally evolved Drosophila and comparative enrichment in human orthologs

    Gaurav Yadav, Prachi Mishra ... Dau Dayal Aggarwal
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Genetics and Genomics
    2. Ecology

    Eco-genomic analysis uncovers precision-conservation targets for the western Pacific’s southernmost salmonid

    Yi-Chien Lee, Zong-Yu Shen ... Sheng-Feng Shen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Developmental Biology
    2. Genetics and Genomics

    Multiple molecular pathways to longevity with opposing gene expression programs defining distinct aging strategies in Caenorhabditis elegans

    Zenith D Rudich, Jiaxi Guan ... Jeremy M Van Raamsdonk
    Comparing gene expression across a panel of nine long-lived mutants in a single study reveals that these mutants utilize both common and unique genetic strategies to achieve long life.
    1. Genetics and Genomics
    2. Neuroscience

    The Drosophila IR20a Integrates L-arginine and Salt Signals via Distinct Subunit Assemblies

    Bo Wang, Guangnan Qu ... Yan Chen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Genetics and Genomics
    2. Evolutionary Biology

    Intersecting experimental evolution and CRISPR screens to identify novel toxin resistance loci

    Michele Marconcini, Steeve Cruchet ... Richard Benton
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Genetics and Genomics
    2. Plant Biology

    The genetic control of rapid genome content divergence in Arabidopsis thaliana

    Christopher J Fiscus, Daniel Koenig
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Sequential and coordinated control of human plasma cell differentiation by IRF4 and BLIMP1 utilizing a discriminating ISRE/EICE motif lexicon

    Louis C Lau, Sneha Lal ... Harinder Singh
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Genetics and Genomics
    2. Physiology

    mTOR regulates longevity through a bile-acid like hormonal mechanism and DHS-26/DHRS1

    Klara Schilling, Alex Zaufel ... Adam Antebi
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Genetics and Genomics

    Sibling chimerism among microglia in marmosets

    Ricardo CH del Rosario, Fenna M Krienen ... Steven A McCarroll
    Sibling-derived chimerism in marmosets is found only in cells of hematopoietic origin, especially microglia and macrophages in the brain, whose proportions vary widely across individuals and brain regions.
    1. Genetics and Genomics
    2. Neuroscience

    Learning is a fundamental source of individuality

    Riddha Manna, Johanni Brea ... Ana Marija Jakšić
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
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Highlights

    1. Genetics and Genomics
    2. Medicine

    Responding to peer reviewers

    Eric Kalkhoven, Manon Kluijtmans
    1. Developmental Biology
    2. Genetics and Genomics

    Written out of history

    Lisa M Thomann, Julie Batut
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Chromosomes: Finding a role for non-coding DNA in trypanosomes

    Markus R Schmidt

Senior editors

  1. Kathryn Cheah
    The University of Hong Kong, Hong Kong SAR China
  2. Murim Choi
    Seoul National University College of Medicine, South Korea
  3. Yamini Dalal
    National Cancer Institute, United States
  4. See more editors