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Latest articles

1. 1. Neuroscience

   Neurotransmitters: The sound of neural silence

   Nikki Tjahjono, Yu-Shun Wang, Lin Tian

   A new fluorescent sensor makes it possible to track the neurotransmitter GABA in freely moving animals.
2. 1. Neuroscience

   Language Models: Does the brain really know what word is coming next?

   Richard J Antonello

   Apparent neural encoding of future words may arise from the statistical structure of language itself, rather than from predictive computations in the brain.
3. 1. Evolutionary Biology
   2. Immunology and Inflammation

   Antibody Language Models: Taking the biology seriously makes models better

   Antonio Matas-Gil, Andreas Tiffeau-Mayer

   A new biologically-informed training paradigm enables protein language models to predict affinity maturation trajectories for antibodies.
4. 1. Neuroscience

   Neuroanatomy: Hidden folds reveal brain organization

   Jürgen Germann

   Previously underappreciated folds in the cerebral cortex provide insight into how its structure varies across individuals.
5. 1. Neuroscience

   Orbitofrontal Cortex: Cocaine disrupts hidden states in the brain

   Margo Le, Ronald Keiflin

   Cocaine use disrupts the encoding of abstract states in the orbitofrontal cortex.
6. 1. Structural Biology and Molecular Biophysics

   Glycobiology: How enzymes make the right choice during biosynthesis

   Ana S Ramírez, Camilo Perez

   The biosynthesis of an important biopolymer called hyaluronan requires an enzyme that discriminates between two different substrates.
7. 1. Neuroscience

   Memory Encoding and Retrieval: Rethinking how memories are retrieved

   Rocco Pizzarelli, Marilena Griguoli

   Patterns of neural activity called theta oscillations have a role in memory encoding but – contrary to current thinking – do not appear to have a role in memory retrieval.
8. 1. Structural Biology and Molecular Biophysics

   Membrane Biology: Two binding sites are better than one

   Mackenzie K Scott, John E Burke

   The reasons why two multiprotein complexes – VPS34 complex I and VPS34 complex II – are activated by different Rab proteins are becoming clearer.
9. 1. Neuroscience

   Psychedelic Drugs: Reshaping human neurons

   Jessica L Maltman, Javier González-Maeso

   Human neurons derived from stem cells show increased structural complexity and stronger synaptic connections after exposure to psilocin, the active metabolite of the psychedelic psilocybin.
10. 1. Structural Biology and Molecular Biophysics

    Membrane Proteins: A missing link for efflux pumps

    Hilal Wehbi, Isabelle Broutin

    A lipoprotein called YbjP could be the answer to a puzzle about efflux pumps in gram-negative bacteria.