Insights

Latest articles

1. 1. Biochemistry and Chemical Biology

   Immunotherapy: The power lies in the glycans

   Luca Unione, Jesús Jiménez-Barbero

   Glycans play an important role in modulating the interactions between natural killer cells and antibodies to fight pathogens and harmful cells.
2. 1. Cell Biology

   Kidney Fibrosis: Lock out SIRT4

   Kaiqiang Zhao, Zhongjun Zhou

   The accumulation of SIRT4 in the nuclei of kidney cells drives kidney fibrosis, so blocking the movement of this protein could be a potential therapeutic strategy against fibrosis.
3. 1. Neuroscience

   Status Epilepticus: Stopping runaway seizures with a chill pill

   Gordon F Buchanan

   The neuropeptide neurotensin can reduce status epilepticus and its associated consequences through induction of therapeutic hypothermia when bound to a molecule that can penetrate the blood-brain barrier.
4. 1. Neuroscience

   Sequential Movement: Reaching into the future

   Raeed H Chowdhury

   When carrying out a sequence of movements, humans can plan several steps in advance to make the movement smooth.
5. 1. Plant Biology

   Seed Germination: Coping with salt stress

   Xiaoyan Liang, Caifu Jiang

   Salt stress delays seed germination in plants by increasing the hydrolysis of arginine-derived urea.
6. 1. Neuroscience

   Locomotion: The rhythm is going to get you

   Mohini Sengupta

   Slow and fast movements are controlled by distinct sets of spinal V2a neurons with matching properties and connections.
7. 1. Cell Biology

   Sensory Neurons: Addressing burning questions on axon regeneration

   Diána Kaszás, Balázs Enyedi

   Regeneration of sensory axons after a burn injury depends on early keratinocyte responses regulated by the wound microenvironment.
8. 1. Cell Biology
   2. Developmental Biology

   Fertilization: Switching on lysosomes

   Deepak Adhikari, John Carroll

   The formation of large endolysosomal structures in unfertilized eggs ensures that lysosomes remain dormant before fertilization, and then shift into clean-up mode after the egg-to-embryo transition.
9. 1. Structural Biology and Molecular Biophysics

   Nuclear Receptors: A new mode of inhibition

   Andrew D Huber, Taosheng Chen

   Complementary structural biology approaches reveal how an agonist and a covalent inhibitor simultaneously bind to a nuclear receptor.
10. 1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Vaccines: How do adjuvants enhance immune responses?

    Rekha R Rapaka

    By altering which peptide antigens are presented to CD4⁺ T cells, adjuvants affect the specificity of the immune response.