Insights

Latest articles

1. 1. Immunology and Inflammation

   Acute Lung Injury: The double-edged nature of trained immunity

   Chrissy M Leopold Wager, Larry S Schlesinger

   Trained immunity in alveolar macrophages can lead to damaging lung inflammation, confirming the importance of context in this phenomenon.
2. 1. Biochemistry and Chemical Biology

   RNA: Searching for druggable targets

   Lana Heganovic, Luiz FM Passalacqua

   A strategy that analyzes the structural properties of RNA could help identify regions that are promising targets for antiviral drugs.
3. 1. Computational and Systems Biology

   Methylation: Modifying gene expression through passive forces

   Sarah Hallstein, Julian König

   The mRNA metabolism passively shapes the levels of an mRNA modification called m6A within a steady-state cell and upon stress.
4. 1. Cancer Biology
   2. Chromosomes and Gene Expression

   Cancer: Reading the DNA of telomeres

   Shamayita Roy, Claus M Azzalin

   Experiments with tools designed to detect DNA damage reveal unique and conserved features of telomeres in cancer cells.
5. 1. Medicine

   Aging: Multiple roles for a mitochondrial enzyme

   Xicong Tang, Hongyu Qiu

   The enzyme arginase-II has an important role in cardiac aging, and blocking it could help hearts stay young longer.
6. 1. Neuroscience

   Touch: A lasting impression

   Rochelle Ackerley, Roger H Watkins

   Touch-sensitive neurons in the fingertips take previous physical contacts into account when relaying tactile information to the brain.
7. 1. Neuroscience

   Neurodevelopmental Disorders: Unraveling the impact of genetic variants

   Bruce Herring

   Experiments in mice reveal how three rare mutations in a gene called TRIO can lead to different neurodevelopmental outcomes.
8. 1. Immunology and Inflammation

   Interferon Signaling: Immobilizing bacteria to prevent infections

   Patricia Reist Iscar, Petr Broz

   The interferon-induced GTPase GVIN1 prevents bacteria from spreading among cells by coating them and rendering them immobile.
9. 1. Cell Biology
   2. Microbiology and Infectious Disease

   Cell Surface Receptors: Virus attacks fish by muscling its way into cells

   Ping-Ping Liu, Zhe Wei, Xian-Wei Wang

   Nervous necrosis virus typically enters host cells via endocytosis, but it can also enter via a process called macropinocytosis.
10. 1. Microbiology and Infectious Disease

    Helicase Loading: A back-up mechanism for replication

    Godefroid Charbon, Anders Løbner-Olesen

    A protein called PriC allows DNA replication to proceed in Escherichia coli when the complex that usually initiates this process is compromised.