Microbiology and infectious disease

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Predicting the pandemic potential of influenza viruses from genetic sequence data could transform pandemic risk assessment but progress towards this goal will require the integration of experimental work, computational tools, and virus surveillance.
Colin A Russell, Peter M Kasson, Ruben O Donis, Steven Riley, John Dunbar, Andrew Rambaut, Jason Asher, Stephen Burke, C Todd Davis, Rebecca J Garten, Sandrasegaram Gnanakaran, Simon I Hay, Sander Herfst, Nicola S Lewis, James O Lloyd-Smith, Catherine A Macken, Sebastian Maurer-Stroh, Elizabeth Neuhaus, Colin R Parrish, Kim M Pepin, Samuel S Shepard, David L Smith, David L Suarez, Susan C Trock, Marc-Alain Widdowson, Dylan B George, Marc Lipsitch, Jesse D Bloom
10.7554/eLife.03883
An experimentally constrained model shows that Escherichia coli faces fitness trade-offs in chemotaxis behaviors, and that adaptation of phenotypic diversity through altered gene regulation permits populations to resolve these trade-offs.
Nicholas W Frankel, William Pontius, Yann S Dufour, Junjiajia Long, Luis Hernandez-Nunez, Thierry Emonet
10.7554/eLife.03526

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