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Microbiology and infectious disease

Microbiology and infectious disease

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Rapid yet comprehensive, genome-resolved analysis of fecal samples from premature infants reveals little overlap in strain composition of gut microbial communities, despite co-hospitalization, and suggests the existence of barriers to strain dispersal.
Tali Raveh-Sadka, Brian C Thomas, Andrea Singh, Brian Firek, Brandon Brooks, Cindy J Castelle, Itai Sharon, Robyn Baker, Misty Good, Michael J Morowitz, Jillian F Banfield
10.7554/eLife.05477
A lack of ADAM10-mediated shedding increases prion protein levels at the plasma membrane and promotes the generation of pathological prion proteins, which accelerates prion disease in mice.
Hermann C Altmeppen, Johannes Prox, Susanne Krasemann, Berta Puig, Katharina Kruszewski, Frank Dohler, Christian Bernreuther, Ana Hoxha, Luise Linsenmeier, Beata Sikorska, Pawel P Liberski, Udo Bartsch, Paul Saftig, Markus Glatzel
10.7554/eLife.04260
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Our work uses the evolutionary lens of comparative analysis of a fungal pathogen to reveal new molecular mechanisms underlying drug resistance and host adaptation. The data and analyses provide a rich resource for other Candida researchers and a host of candidate genes for further functional studies.
Christopher B Ford, Jason M Funt, Darren Abbey, Luca Issi, Candace Guiducci, Diego A Martinez, Toni Delorey, Bi yu Li, Theodore C White, Christina Cuomo, Reeta P Rao, Judith Berman, Dawn A Thompson, Aviv Regev
10.7554/eLife.00662
Mucosal application of the anti-retroviral drug tenofovir, which is intended to prevent HIV transmission, has many off-target effects on the mucosa itself.
Florian Hladik, Adam Burgener, Lamar Ballweber, Raphael Gottardo, Lucia Vojtech, Slim Fourati, James Y Dai, Mark J Cameron, Johanna Strobl, Sean M Hughes, Craig Hoesley, Philip Andrew, Sherri Johnson, Jeanna Piper, David R Friend, T Blake Ball, Ross D Cranston, Kenneth H Mayer, M Juliana McElrath, Ian McGowan
10.7554/eLife.04525
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The death of bacterial kin cells releases a danger signal that activates a posttranscriptional response in surviving cells, resulting in the rapid elaboration of interbacterial competition factors.
Michele LeRoux, Robin L Kirkpatrick, Elena I Montauti, Bao Q Tran, S Brook Peterson, Brittany N Harding, John C Whitney, Alistair B Russell, Beth Traxler, Young Ah Goo, David R Goodlett, Paul A Wiggins, Joseph D Mougous
10.7554/eLife.05701
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A mathematical model that combines stochasticity and spatial structure describes the dynamics of the viral population during an infection cycle, and fitting the model to RNA and virus abundances over time shows that poliovirus follows a geometric replication mode.
Michael B Schulte, Jeremy A Draghi, Joshua B Plotkin, Raul Andino
10.7554/eLife.03753

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Showing results 1 - 10 of 114