Microbiology and infectious disease

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Bacterial viruses are an unexpected ‘third party’ that imposes a strong predatory pressure on a bacterial pathogen during the natural course of infection in humans.
Kimberley D Seed, Minmin Yen, B Jesse Shapiro, Isabelle J Hilaire, Richelle C Charles, Jessica E Teng, Louise C Ivers, Jacques Boncy, Jason B Harris, Andrew Camilli
10.7554/eLife.03497
Deep mutational scanning was used to comprehensively quantify the effects of mutations to influenza hemagglutinin and shows that the virus possesses a high inherent mutational tolerance at key antigenic sites.
Bargavi Thyagarajan, Jesse D Bloom
10.7554/eLife.03300
Maps defining environmental risk of the leishmaniases provide insights into the ecology of these diseases and identify regions to target public health measures and inform future burden estimates.
David M Pigott, Samir Bhatt, Nick Golding, Kirsten A Duda, Katherine E Battle, Oliver J Brady, Jane P Messina, Yves Balard, Patrick Bastien, Francine Pratlong, John S Brownstein, Clark C Freifeld, Sumiko R Mekaru, Peter W Gething, Dylan B George, Monica F Myers, Richard Reithinger, Simon I Hay
10.7554/eLife.02851
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Novel virus-host systems yield insights into how Lepidopterans (moths and butterflies) combat RNA virus infection and reveal that poxvirus A51R proteins can suppress the host's immune system and stabilize microtubules in host cells.
Don B Gammon, Sophie Duraffour, Daniel K Rozelle, Heidi Hehnly, Rita Sharma, Michael E Sparks, Cara C West, Ying Chen, James J Moresco, Graciela Andrei, John H Connor, Darryl Conte Jr., Dawn E Gundersen-Rindal, William L Marshall, John R Yates, Neal Silverman, Craig C Mello
10.7554/eLife.02910
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Metabolite analysis of plasma from enteric fever patients define signals of organism specific host–pathogen interactions and provides opportunities for new diagnostics.
Elin Näsström, Nga Tran Vu Thieu, Sabina Dongol, Abhilasha Karkey, Phat Voong Vinh, Tuyen Ha Thanh, Anders Johansson, Amit Arjyal, Guy Thwaites, Christiane Dolecek, Buddha Basnyat, Stephen Baker, Henrik Antti
10.7554/eLife.03100
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Show10255075100rows
Showing results 1 - 10 of 64