Microbiology and infectious disease

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Maps defining environmental risk of the leishmaniases provide insights into the ecology of these diseases and identify regions to target public health measures and inform future burden estimates.
David M Pigott, Samir Bhatt, Nick Golding, Kirsten A Duda, Katherine E Battle, Oliver J Brady, Jane P Messina, Yves Balard, Patrick Bastien, Francine Pratlong, John S Brownstein, Clark C Freifeld, Sumiko R Mekaru, Peter W Gething, Dylan B George, Monica F Myers, Richard Reithinger, Simon I Hay
10.7554/eLife.02851
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Metabolite analysis of plasma from enteric fever patients define signals of organism specific host–pathogen interactions and provides opportunities for new diagnostics.
Elin Näsström, Nga Tran Vu Thieu, Sabina Dongol, Abhilasha Karkey, Phat Voong Vinh, Tuyen Ha Thanh, Anders Johansson, Amit Arjyal, Guy Thwaites, Christiane Dolecek, Buddha Basnyat, Stephen Baker, Henrik Antti
10.7554/eLife.03100
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Translation quality control protects the cell from environmental stresses that could potentially lead to the toxic accumulation of non-proteinogenic amino acids in the proteome.
Tammy J Bullwinkle, Noah M Reynolds, Medha Raina, Adil Moghal, Eleftheria Matsa, Andrei Rajkovic, Huseyin Kayadibi, Farbod Fazlollahi, Christopher Ryan, Nathaniel Howitz, Kym F Faull, Beth A Lazazzera, Michael Ibba
10.7554/eLife.02501
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In vitro, in vivo and in silico evidence suggests that bacteria exploit intrinsic chromosomal fluctuations to achieve intracellular transport.
Hoong Chuin Lim, Ivan Vladimirovich Surovtsev, Bruno Gabriel Beltran, Fang Huang, Jörg Bewersdorf, Christine Jacobs-Wagner
10.7554/eLife.02758
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A combination of X-ray crystallography, molecular dynamics and small angle X-ray scattering shows that the transcription antiterminator M2-1 is a structurally dynamic homotetramer that undergoes large concerted conformational changes upon binding its target RNA.
Cedric Leyrat, Max Renner, Karl Harlos, Juha T Huiskonen, Jonathan M Grimes
10.7554/eLife.02674

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