A Research Advance is a short article that allows either the authors of an eLife paper or other researchers to publish new results that build on the original research paper in an important way.
Commonly used covalent PPARγ inhibitors weaken, but do not block, binding of other ligands via an allosteric mechanism where ligands clash with a covalent ligand-induced transcriptionally repressive structural conformation.
Sebastian Quiroz Monnens, Casper Peters ... Bernhard Englitz
The recurrent temporal restricted Boltzmann machine applied to whole-brain neuronal recordings from larval zebrafish brains provides substantial advantages in discovering the neuronal assembly structure and their connectivity.
Aurélie Anne-Gaëlle Gabriel, Julien Racle ... David Gfeller
EPIC-ATAC accurately quantifies cell-type heterogeneity in tumor bulk ATAC-Seq samples using reliable cell-type specific chromatin accessibility markers for the major cell types found in tumor microenvironments.
Yucheng Liang, Jean-Emmanuel Hugonnet ... Michel Arthur
The Braun lipoprotein is tethered to peptidoglycan independently from the insertion of newly-synthesized peptidoglycan subunits into the expanding cell wall generating a dynamic equilibrium between free and bound protein forms.
Chileleko Siachisumo, Sara Luzzi ... David J Elliott
A family of RNA binding proteins that diverged 200 million years ago have parallel roles in protecting the transcriptomic integrity of ultra-long exons within their respective cell types.
In a mouse model of Sjogren's disease, mitochondrial function and Ca2+ signaling are disrupted resulting in altered coupling between Ca2+ release and Ca2+ activated Cl- channels and salivary gland hypofunction.
Benjamin R Kop, Yazan Shamli Oghli ... Lennart Verhagen
Realizing the clinical and neuroscientific potential of transcranial ultrasonic stimulation (TUS) requires careful control of the peripheral auditory confounds that underlie previously reported online motor inhibitory effects.
Lisa Baumgartner, Jonathan J Ipsaro ... Julius Brennecke
Genetic and biochemical characterization reveals how a single amino acid change in the chromodomain of the HP1 protein Rhino enables its specific interaction with the guidance factor Kipferl.
Amin MD Shakhawat, Jacqueline G Foltz ... Jennifer L Raymond
The capacity for new cerebellum-dependent learning is influenced by the recent history of neural activity in a mouse model of Fragile X syndrome, suggesting a role for metaplasticity.
