Short Reports

A Short Report allows authors to publish the results of a small number of experiments, provided the conclusion is clear and justified, and the findings are novel and judged to be of high importance.

Latest articles

    1. Neuroscience

    Rank- and threat-dependent social modulation of innate defensive behaviors

    Ling-yun Li, Xinjian Gao ... Ya-tang Li
    Social context modulates innate defensive behaviors in a rank- and threat-dependent manner, while threat experience reinforces social roles, revealing a bidirectional interplay between defensive and social behavior.
    Version of Record
    Short Report
    • Important
    • Convincing
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    The C3–C3aR axis modulates trained immunity in alveolar macrophages

    Alexander P Earhart, Alberto E Lopez ... Hrishikesh S Kulkarni
    Complement component C3, a key component of immune responses at mucosal sites, affects alveolar macrophage reprogramming via the C3aR.
    Version of Record
    Short Report
    • Important
    • Convincing
    1. Cancer Biology
    2. Cell Biology

    Slap restricts oncogenic Src-family kinase signaling to maintain colonic epithelial homeostasis

    Dana Naim, Zouheir Houhou ... Serge Roche
    Src-like adaptor protein (SLAP) preserves intestinal epithelial homeostasis by restraining Src-family kinase signaling, revealing a non-genetic mechanism limiting colorectal tumor initiation.
    Version of Record
    Short Report
    • Important
    • Solid
    1. Neuroscience

    Perceiving animacy in ‘identical’ images

    Tal Boger, Chaz Firestone
    Visual anagrams, images whose interpretations change with orientation, isolate visual processing of animacy itself, beyond its lower-level correlates.
    Version of Record
    Short Report
    • Important
    • Convincing
    1. Computational and Systems Biology

    Benchmarking biochemical networks generated by large language models

    Jeevan Tewari, Benjamin W Dahl ... Jeffrey J Saucerman
    Current general-purpose large language models generate signaling and metabolic networks with only modest accuracy relative to manually curated network models.
    Version of Record
    Short Report
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Non-canonical amino acid incorporation enables minimally disruptive labeling of stress granule and TDP-43 proteinopathy

    Hao Chen, Haocheng Wang ... Jiou Wang
    Minimally disruptive genetic code expansion enables faithful, site-specific labeling of G3BP1 and TDP-43, revealing native stress granule dynamics and ALS-linked protein behavior in live cells.
    1. Neuroscience

    Experience shapes the transformation of olfactory representations along the cortico-hippocampal pathway

    Eleonore Schiltz, Martijn Broux ... Haesler Sebastian
    The representation of stimulus identity and experience is transformed from primary olfactory cortex to memory-related multisensory areas in the hippocampus.
    Version of Record
    Short Report
    • Important
    • Solid
    1. Neuroscience

    Adult-neurogenesis allows for representational stability and flexibility in early olfactory system

    Zhen Chen, Krishnan Padmanabhan
    Using computational and theoretical models shows how adult-neurogenesis and spike-timing-dependent plasticity balance the flexibility and stability of odor representations.
    Version of Record
    Short Report
    • Important
    • Incomplete
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Evidence of off-target probe binding affecting 10x Genomics Xenium gene panels compromise accuracy of spatial transcriptomic profiling

    Caleb Hallinan, Hyun Joo Ji ... Jean Fan
    Computational assessment identifies probe binding errors in a widely used commercial platform for spatial transcriptomics.
    Version of Record
    Short Report
    • Valuable
    • Convincing
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Single-cell RNA-seq reveals trans-sialidase-like superfamily gene expression heterogeneity in Trypanosoma cruzi populations

    Lucas Inchausti, Lucia Bilbao ... Pablo Smircich
    Transcriptomic heterogeneity in infective-stage surface proteins of Trypanosoma cruzi, particularly trans-sialidase-like superfamily members, suggests distinct expression profiles among individual parasites that may enhance immune evasion and infection adaptability.
    Version of Record
    Short Report
    • Important
    • Convincing