Isobel Parkes, Ara Schorscher-Petcu ... Liam E Browne
A closed-loop system delivers cutaneous optical stimulation during movement in freely behaving mice, enabling controlled somatosensory input in naturalistic settings.
A comprehensive toolkit enables genome-wide, recombinase-independent mosaic analysis in Drosophila, permitting clonal analysis of pericentromeric genes, deficiency chromosomes, and interspecific hybrids previously inaccessible to standard methods.
New synaptically targeted GCaMP8 sensors and analysis tools capture calcium dynamics with the speed and sensitivity previously achievable only through electrophysiology and chemical dyes.
Comprehensive residue-level mapping of amyloid-beta recognition reveals how sequence variants, post-translational modifications, and aggregation state shape antibody specificity, thereby guiding selection and development of therapeutic antibodies in Alzheimer’s disease.
Ziv Yaniv, Ifeanyichukwu U Anidi ... Andrea J Radtke
A dynamic, community-driven knowledge repository reduces research costs and accelerates scientific discovery by sharing validated reagent data, negative results, and protocols while rewarding contributors through formal authorship recognition.
James B Isbister, András Ecker ... Michael W Reimann
A general and open multiscale cortical model is presented which can be used by the community to study neural coding, spike sorting, plasticity, optogenetic and extracellular stimulation, local field potential, and electroencephalography.
Michael W Reimann, Sirio Bolaños-Puchet ... Srikanth Ramaswamy
A morphologically detailed model of brain region anatomy serves as the foundation for biophysically detailed simulations and provides insights into local and inter-regional connectivity.
