New synaptically targeted GCaMP8 sensors and analysis tools capture calcium dynamics with the speed and sensitivity previously achievable only through electrophysiology and chemical dyes.
Comprehensive residue-level mapping of amyloid-beta recognition reveals how sequence variants, post-translational modifications, and aggregation state shape antibody specificity, thereby guiding selection and development of therapeutic antibodies in Alzheimer’s disease.
Ziv Yaniv, Ifeanyichukwu U Anidi ... Andrea J Radtke
A dynamic, community-driven knowledge repository reduces research costs and accelerates scientific discovery by sharing validated reagent data, negative results, and protocols while rewarding contributors through formal authorship recognition.
Michael W Reimann, Sirio Bolaños-Puchet ... Srikanth Ramaswamy
A morphologically detailed model of brain region anatomy serves as the foundation for biophysically detailed simulations and provides insights into local and inter-regional connectivity.
James B Isbister, András Ecker ... Michael W Reimann
A general and open multiscale cortical model is presented which can be used by the community to study neural coding, spike sorting, plasticity, optogenetic and extracellular stimulation, local field potential, and electroencephalography.
Jakob Cronshagen, Johannes Allweier ... Tobias Spielmann
The generation of malaria parasites expressing only one of the multiple variants of their most important virulence factor enables the study of different aspects of this virulence factor.
R Sai Prathap Yadav, Paulami Dey ... Pavan Agrawal
A low-cost, portable platform combining machine learning–based classifiers enables accurate quantification of Drosophila aggression and courtship, expanding access to behavioral neuroscience in resource-limited settings.
