A robust method to infer excitatory and inhibitory synaptic conductances from neuronal recordings reveals functional circuit organization in rhythmic networks.
Self-supervised deep learning models can accurately perform 3D segmentation of cell nuclei in complex biological tissues, enabling scalable analysis in settings with limited or no ground truth annotations.
SCellBOW is a language model-based scRNA-seq analysis method that identifies malignant cell subpopulations and infers marker-free survival risks using transfer learning.
The development of an automated micronucleus segmentation program enables population-level comparisons between cells with and without micronuclei and defines a highly limited response to micronucleus formation or rupture.
AACDB provides a comprehensive, manually curated antigen-antibody interface dataset with rich metadata, interaction annotations, and therapeutic target annotations to advance antibody drug development.
Sarah Benkeder, Son-Michel Dinh ... Jean-Christophe Comte
MorphoCellSorter is a versatile, user-friendly tool that automates microglial morphology ranking, enabling standardized, reproducible analysis across diverse models, imaging techniques, and conditions using principal component analysis and Andrews plots.
Derek G Epiney, Gonzalo Morales Chaya ... Chris Q Doe
The central complex of the adult Drosophila brain, required for sensorimotor integration, is transcriptionally complex as detected by single-cell transcriptome analysis.
Noëmie Mermet-Joret, Andrea Moreno ... Sadegh Nabavi
An optogenetic system capable of precise, high-frequency neuronal excitation using red pulsed light and rapid, millisecond inhibition using blue light.
ADPT enhances the robustness of animal pose estimation by minimizing keypoint tracking drift, enabling more accurate multi-animal tracking and facilitating refined behavioral analysis across species.
Novel genetically encoded tools PFE3, paGFE3, and chGFE3 can be used to reversibly ablate excitatory synapses constitutively, and inhibitory synapses in a light- or chemically dependent manner.
