In contrast to differential expression-based methods, which evaluate and select individual marker genes, CellCover identifies panels of genes that function together to define cell types.
Krassimira A Garbett, James P Allen ... Richard C Sando
Long-term live imaging and tracking approaches reveal a coordination between excitatory and inhibitory synapse assembly, despite continual spatiotemporal dynamics.
Elvi Gil Lievana, Benjamin Arroyo ... Ranier Gutierrez
Making the moment-to-moment dynamics of solid-food intake measurable in any laboratory enables researchers to map the brain circuits that control appetite and accelerate the development of treatments for obesity.
Celldetective is an open-source software integrating segmentation, tracking, and event detection to perform high-throughput end-to-end study of dynamic cell interactions, without requiring coding skills, demonstrated on microscopy immunological assays.
David L Haggerty, Caleb Browning Darden, David Lovinger
Integrated pose estimation, video acquisition, and edge deployment tools make real-time behavioral analysis more accessible to neuroscience laboratories.
David Sidarta-Oliveira, Ana I Domingos, Licio A Velloso
A framework for analyzing single-cell genomics data, in which geometrical properties are harnessed to obtain insights on cellular diversity, including precise clustering, clear visualizations, and intuitive diagnostics.
Transcriptomic profiling of the developing human outflow tract and adult aortic valves reveals that adult valve cells retain distinct embryonic molecular signatures.
Andrea Cuentas-Condori, Patricia Chanabá-López ... Daniel A Colón-Ramos
Endogenous tagging and conditional silencing of vesicular transporters reveal widespread, conserved co-transmission, and enable causal dissection of transmitter-specific synaptic function, linking molecular identity to circuit dynamics and behavior in vivo.
