Executable Research Articles

ERAs set a new, open standard for the transparency, interactivity and reproducibility of published research. Authored with popular tools such as Jupyter Notebooks and R Markdown, ERA is available for all papers published in eLife. Read about the experiences of our first authors in this Labs post. Our new collection showcases the breadth and variety of possibilities this new format offers. Find out more about how you can use ERA to enrich your research.

Collection

1. 1. Developmental Biology
   2. Evolutionary Biology

   Ecdysone coordinates plastic growth with robust pattern in the developing wing

   André Nogueira Alves, Marisa Mateus Oliveira ... Christen Kerry Mirth

   Wings achieve plasticity in size while maintaining robust pattern via ecdysone, which elicits graded responses for growth rates and threshold responses for patterning rates, in the fruit fly Drosophila melanogaster.
2. 1. Computational and Systems Biology
   2. Medicine

   Meta-Research: Author-level data confirm the widening gender gap in publishing rates during COVID-19

   Emil Bargmann Madsen, Mathias Wullum Nielsen ... Jens Peter Andersen

   The gender gap in publication productivity has increased during the COVID-19 pandemic, with potential implications for the careers of women working in research.
3. 1. Medicine
   2. Microbiology and Infectious Disease

   Combination of inflammatory and vascular markers in the febrile phase of dengue is associated with more severe outcomes

   Nguyen Lam Vuong, Phung Khanh Lam ... Sophie Yacoub

   Relationships of biomarkers with clinical outcome differed between children and adults and the best combinations associated with moderate/severe dengue comprised of six/seven vascular and immune biomarkers.
4. 1. Computational and Systems Biology
   2. Neuroscience

   Neuronal timescales are functionally dynamic and shaped by cortical microarchitecture

   Richard Gao, Ruud L van den Brink ... Bradley Voytek

   Invasive electrophysiological recording measures neuronal transmembrane current timescales across human cortex, which lengthens from sensory to association regions, follows variations in ion channel expressions, and alters with behavior and aging.
5. 1. Epidemiology and Global Health
   2. Medicine

   An agnostic study of associations between ABO and RhD blood group and phenome-wide disease risk

   Torsten Dahlén, Mark Clements ... Gustaf Edgren

   The relationship between blood groups and disease is detangled, without preconceived ideas, using population-wide data, with millions of participants and lifetime follow-up, identifying not only previously known relationships but also new insights.
6. 1. Computational and Systems Biology

   Stochastic logistic models reproduce experimental time series of microbial communities

   Lana Descheemaeker, Sophie de Buyl

   Properties of various microbial communities time series, such as the noise color and neutrality, are captured by stochastic generalized Lotka-Volterra equations, even in the absence of interactions.
7. 1. Evolutionary Biology
   2. Microbiology and Infectious Disease

   Formicine ants swallow their highly acidic poison for gut microbial selection and control

   Simon Tragust, Claudia Herrmann ... Heike Feldhaar

   Poison acidified crops sanitize food and limit disease transmission while at the same time structuring the gut microbiota and thus contribute to the ecological and evolutionary success of formicine ants.
8. 1. Neuroscience

   An interactive meta-analysis of MRI biomarkers of myelin

   Matteo Mancini, Agah Karakuzu ... Nikola Stikov

   Most MRI-based myelin biomarkers are not statistically different regarding their relationship with histology.

9. Meta-Research: Evaluating the impact of open access policies on research institutions

   Chun-Kai (Karl) Huang, Cameron Neylon ... Chloe Brookes-Kenworthy

   A longitudinal study of open access levels at 1,207 research institutions worldwide reveals high performing institutions in Latin America, Africa and Asia.
10. 1. Epidemiology and Global Health

    Collider bias and the apparent protective effect of glucose-6-phosphate dehydrogenase deficiency on cerebral malaria

    James A Watson, Stije J Leopold ... Nicholas J White

    Selection bias, also known as collider bias, likely explains the apparent protective effect of G6PD deficiency against cerebral falciparum malaria.
11. 1. Neuroscience

    Inter- and intra-animal variation in the integrative properties of stellate cells in the medial entorhinal cortex

    Hugh Pastoll, Derek L Garden ... Matthew F Nolan

    Setpoints that determine the integrative properties of neurons in the medial entorhinal cortex are established at a population level and differ between animals.
12. 1. Cancer Biology

    Replication Study: Transcriptional amplification in tumor cells with elevated c-Myc

    L Michelle Lewis, Meredith C Edwards ... Reproducibility Project: Cancer Biology

    Editors' Summary: This Replication Study has reproduced important parts of the original paper, but it also contains results that are not consistent with some parts of the original paper.