2,726 results found
    1. Developmental Biology
    2. Physics of Living Systems

    Mother cells control daughter cell proliferation in intestinal organoids to minimize proliferation fluctuations

    Guizela Huelsz-Prince, Rutger Nico Ulbe Kok ... Jeroen S van Zon
    Tracking of all cells in intestinal organoids crypts to fully reconstruct cell lineages reveals that proliferative behavior is highly symmetric between sisters cells, while simulations show that this observed symmetry minimizes random fluctuations in cell proliferation, thereby ensuring homeostasis.
    1. Plant Biology

    Fluctuations of the transcription factor ATML1 generate the pattern of giant cells in the Arabidopsis sepal

    Heather M Meyer, José Teles ... Adrienne H K Roeder
    Fluctuations of a transcription factor that coincide with the G2 phase of the cell cycle pattern two interspersed cell fates in a multicellular system.
    1. Cell Biology

    Mechanisms of organelle biogenesis govern stochastic fluctuations in organelle abundance

    Shankar Mukherji, Erin K O'Shea
    A systematic comparison of experimentally measured and theoretically predicted magnitudes of organelle abundance fluctuations suggests that budding yeast produces the maximum level of variability in organelle abundance that can be generated by organelle biogenesis pathways.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Multiple sources of slow activity fluctuations in a bacterial chemosensory network

    Remy Colin, Christelle Rosazza ... Victor Sourjik
    Single-cell FRET measurements reveal large temporal activity fluctuations within this signaling pathway in Escherichia coli, caused by stochasticity of receptor methylation combined with allosteric interactions and slow rearrangements within receptor clusters.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Metrics of high cofluctuation and entropy to describe control of cardiac function in the stellate ganglion

    Nil Z Gurel, Koustubh B Sudarshan ... Olujimi A Ajijola
    Networked cardiac control, revealed through analysis of extended baseline-state multi-channel recordings, differentiates heart failure and normal regimes highlighting the promise of peripheral neurally based clinical interventions.
    1. Neuroscience

    Large-scale network integration in the human brain tracks temporal fluctuations in memory encoding performance

    Ruedeerat Keerativittayayut, Ryuta Aoki ... Kiyoshi Nakahara
    Graph analysis revealed that spontaneous fluctuations of episodic-memory encoding performance associate with time-varying brain connectivity networks.
    1. Neuroscience

    Lognormal firing rate distribution reveals prominent fluctuation–driven regime in spinal motor networks

    Peter C Petersen, Rune W Berg
    Neuronal participation in generation of motor patterns in the spinal circuits is lognormal, which is an indication of a rich diversity of activity within the mean-driven as well as the fluctuation-driven regimes.
    1. Ecology
    2. Microbiology and Infectious Disease

    Competition for fluctuating resources reproduces statistics of species abundance over time across wide-ranging microbiotas

    Po-Yi Ho, Benjamin H Good, Kerwyn Casey Huang
    A simple model provides an accessible framework to infer macroscopic parameters of effective resource competition from longitudinal studies of microbial communities.
    1. Cell Biology
    2. Physics of Living Systems

    Volume growth in animal cells is cell cycle dependent and shows additive fluctuations

    Clotilde Cadart, Larisa Venkova ... Marco Cosentino Lagomarsino
    High-throughput measurement of single-cell volume reveals the short and large timescale fluctuation patterns of animal cell volume growth.
    1. Neuroscience

    Response outcome gates the effect of spontaneous cortical state fluctuations on perceptual decisions

    Davide Reato, Raphael Steinfeld ... Alfonso Renart
    In a forced-choice auditory discrimination task, mice are more accurate if neural activity in the auditory cortex in the pre-stimulus baseline is higher and more desynchronized, but only if the previous trial was an error.

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