7 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases

    Huaibin Chen, William M Marsiglia ... Moosa Mohammadi
    A four-switch long-range allosteric network controls FGF receptor kinase conformational dynamics as well as activity and is applicable to other receptor tyrosine kinases.
    1. Neuroscience

    Gap junction-mediated glycinergic inhibition ensures precise temporal patterning in vocal behavior

    Boris P Chagnaud, Jonathan T Perelmuter ... Andrew H Bass
    Inhibition provides a means for achieving temporal precision for rapid modulation of an acoustic signal in a vertebrate vocal network.
    1. Developmental Biology

    Multipotent versus differentiated cell fate selection in the developing Drosophila airways

    Ryo Matsuda, Chie Hosono ... Kaoru Saigo
    A genetic framework that balances the numbers of multipotent precursors and differentiated cells in the developing airways of Drosophila is presented.
    1. Microbiology and Infectious Disease

    Antimicrobials from a feline commensal bacterium inhibit skin infection by drug-resistant S. pseudintermedius

    Alan M O'Neill, Kate A Worthing ... Richard L Gallo
    The discovery and development of a feline skin commensal bacterium for bacteriotherapy against skin disease, that could benefit patients due to established low cytotoxicity, broad-spectrum antimicrobial activity and anti-inflammatory activity.
    1. Evolutionary Biology

    Multi-step vs. single-step resistance evolution under different drugs, pharmacokinetics, and treatment regimens

    Claudia Igler, Jens Rolff, Roland Regoes
    The number and effects of mutations leading to full drug resistance crucially determine treatment failure probability and should be used to inform antimicrobial treatment strategies with regard to avoidance of resistance emergence.
    1. Neuroscience

    Connectomics of the Octopus vulgaris vertical lobe provides insight into conserved and novel principles of a memory acquisition network

    Flavie Bidel, Yaron Meirovitch ... Binyamin Hochner
    Connectomics of the octopus 'fan-out fan-in’ learning network reveals that the intermediate layer uses approximately 22×106 excitatory interneurons, each can store a single sensory input, while approximately 400×103 integrating inhibitory interneurons adjust the network output level.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Predicting bacterial promoter function and evolution from random sequences

    Mato Lagator, Srdjan Sarikas ... Gašper Tkačik
    An inferred mechanistic model that connects sequence (genotype) to function (constitutive gene expression phenotype) for any random sequence in Escherichia coli reveals the structure of constitutive promoters and how they evolve.

Refine your results by:

Type
Research categories