Nicole L Nuckolls, Anthony C Mok ... Sarah E Zanders
The Wtf4 antidote protein assembles with the Wtf4 poison protein and promotes the transportation of the assembled proteins to the vacuole for sequestration or destruction.
Sarah E Zanders, Michael T Eickbush ... Harmit Singh Malik
Rapid acquisition of chromosome rearrangements, together with independently acting transmission distorter alleles on each chromosome, drive near complete sterility in fission yeast hybrids.
Nicole L Nuckolls, María Angélica Bravo Núñez ... Sarah E Zanders
Selfish wtf meiotic drive genes use overlapping transcripts to encode both a trans-acting poison to kill gametes that do not inherit the gene and a gamete-autonomous antidote to specifically rescue the gametes that do.
Michael Habig, Gert HJ Kema, Eva Holtgrewe Stukenbrock
Female-inherited supernumerary chromosomes that lack a male-inherited homolog are transmitted to all meiotic products instead of the expected half, which indicates an additional amplification of unpaired chromosomes during meiosis.
María Angélica Bravo Núñez, Ibrahim M Sabbarini ... Sarah E Zanders
The wtf meiotic drivers change the fitness landscape of meiosis in outcrossed Schizosaccharomyces pombe demonstrating that genetic parasites can favor the evolution of variants that disrupt meiotic fidelity.
Ching-Ho Chang, Isabel Mejia Natividad, Harmit S Malik
Genetic conflicts between sex chromosomes during spermatogenesis may drive the rapid evolution, function, and turnover of some sperm nuclear basic proteins in Drosophila species.