4,977 results found
    1. Ecology
    2. Evolutionary Biology
    Zebrafish illustration

    The Natural History of Model Organisms: Advancing biology through a deeper understanding of zebrafish ecology and evolution

    David M Parichy
    The zebrafish is a premier model organism for biomedical research, with a rich array of tools and genomic resources, and combining these with a fuller appreciation of wild zebrafish ecology could greatly extend its utility in biological research.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Ecological adaptation in Atlantic herring is associated with large shifts in allele frequencies at hundreds of loci

    Fan Han, Minal Jamsandekar ... Leif Andersson
    Hundreds of loci underlying ecological adaptation to different environmental conditions show striking differences in allele frequencies between ecotypes of Atlantic herring.
    1. Evolutionary Biology
    2. Neuroscience

    Linking the evolution of two prefrontal brain regions to social and foraging challenges in primates

    Sebastien Bouret, Emmanuel Paradis ... Cecile Garcia
    Across primates, volumes of specific brain regions relate to specific socio-ecological factors, bridging the gap between neuro-cognitive operations from laboratory studies and challenges primates face in their natural environment.
    1. Cancer Biology
    2. Computational and Systems Biology

    Luminal epithelial cells integrate variable responses to aging into stereotypical changes that underlie breast cancer susceptibility

    Rosalyn W Sayaman, Masaru Miyano ... Mark A LaBarge
    Breast luminal epithelial cells are the hotspots of aging-associated changes, which prime aged epithelia for oncogenic gene activation and may explain individual differences in breast cancer susceptibility due to the aging-associated increase in gene expression variances in luminal epithelia.
    1. Computational and Systems Biology
    2. Ecology

    Nomadic-colonial life strategies enable paradoxical survival and growth despite habitat destruction

    Zhi Xuan Tan, Kang Hao Cheong
    By modelling organisms that alternate between individual and colonial lifestyles, the well-known Parrondo's paradox can emerge in an ecological setting without the need for stochastic environmental variation.
    1. Cell Biology
    2. Evolutionary Biology

    Phylogenetic divergence of cell biological features

    Michael Lynch
    Cell biological features are subject to stochastic forces of mutation and random genetic drift, which together cause lineages exposed to identical selection pressures to diverge, and mean phenotypes to deviate from expectations under optimizing selection.
    1. Ecology
    2. Genetics and Genomics
    Budding yeast illustration

    The Natural History of Model Organisms: The fascinating and secret wild life of the budding yeast S. cerevisiae

    Gianni Liti
    The yeast Saccharomyces cerevisiae has informed our understanding of molecular biology and genetics for decades, and learning more about its natural history could fuel a new era of functional and evolutionary studies of this classic model organism.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Metabolism: Division of labor in bacteria

    Alma Dal Co, Charlotte Brannon, Martin Ackermann
    The emergence of subpopulations that perform distinct metabolic roles has been observed in populations of genetically identical bacteria.
    Version of Record
    Insight
    1. Genetics and Genomics
    2. Plant Biology

    DNA methylation in Arabidopsis has a genetic basis and shows evidence of local adaptation

    Manu J Dubin, Pei Zhang ... Magnus Nordborg
    The adaptation of Arabidopsis plants to the local environment is linked to DNA methylation.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Smoking, alcohol consumption, and 24 gastrointestinal diseases: Mendelian randomization analysis

    Shuai Yuan, Jie Chen ... Susanna C Larsson
    Smoking is a risk factor for a broad range of gastrointestinal diseases independent of alcohol consumption.

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