Rigorous analysis in two knockout mouse lines demonstrates that death receptor 6 is not required for axon degeneration or Schwann cell injury responses following peripheral nerve transection.
Uev1A and APC/C degrade CycA to counteract oncogenic Ras, thereby protecting against cell death in polyploid Drosophila nurse cells and suppressing overgrowth in diploid germline and human colorectal tumor cells.
Vikash Verma, Patricia Wadsworth, Thomas J Maresca
TIRF imaging of CRISPR-edited human cells shows dynein–dynactin complexes move processively with motility parameters consistent with the presence of multi-dynein assemblies (>one dynein heavy chain dimer per dynactin) in cells.
