BK and CaV1.3 channels interact early during biogenesis, assembling intracellularly before membrane localization, indicating coordinated processes for functional coupling.
Exosome-associated THSD7A is identified as a key trigger of filopodia formation in cancer cells and neurons, revealing a novel pathway with implications for metastasis, neuronal connectivity, and other filopodia-dependent processes.
Giulia Di Bartolomei, Raúl Ortiz ... Peter Scheiffele
An alternative splicing regulator previously implicated in calcium signaling in the heart ensures cell-type-specific mRNA processing of long neuronal mRNAs in the mouse brain.
A shift in the balance between two lipids – cholesterol and sphingomyelin – makes hybrid epithelial-mesenchymal cancer cells less responsive to certain chemotherapy drugs.
Lipid imbalance triggered by Snail-driven epithelial–mesenchymal transition creates a cholesterol-dependent vulnerability that can be therapeutically targeted to overcome chemoresistance in cancer.
J Ignacio Gutierrez, Claudia Edgar, Jessica K Tyler
Live imaging analyses in budding yeast reveal that calorie restriction and overexpression of the mRNA binding protein Ssd1 both block deleterious age-dependent iron uptake as a mechanism to extend lifespan.
Sarah E Sandkuhler, Kayla S Youngs ... Samuel J Mackenzie
Evidence from multiple model systems supports a shift away from heme transport and toward metabolic dysfunction and oxidative stress as key drivers of TANGO2 deficiency.
