Browse our latest Computational and Systems Biology articles

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    1. Computational and Systems Biology
    2. Neuroscience

    A dynamic scale-mixture model of motion in natural scenes

    Jared M Salisbury, Stephanie E Palmer
    A simple statistical model captures the essential features of object motion in a large database of natural scenes, helping to shed light on the challenges posed to sensory and motor systems.
    1. Neuroscience
    2. Computational and Systems Biology

    Real-Time Closed-Loop Feedback System For Mouse Mesoscale Cortical Signal And Movement Control: CLoPy

    Pankaj K Gupta, Timothy H Murphy
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Computational and Systems Biology

    Nonlinear transcriptional responses to gradual modulation of transcription factor dosage

    Júlia Domingo, Mariia Minaeva ... Tuuli Lappalainen
    A new CRISPR-based approach for tuning gene expression up and down allowed identification of how other genes' expression responds to changes of transcription factors.
    1. Developmental Biology
    2. Computational and Systems Biology

    A quantitative pipeline for whole-mount deep imaging and analysis of multi-layered organoids across scales

    Alice Gros, Jules Vanaret ... Sham Tlili
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Ecology
    2. Computational and Systems Biology

    How bats exit a crowded colony when relying on echolocation only - a modeling approach

    Omer Mazar, Yossi Yovel
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Computational and Systems Biology

    Predicting the effect of CRISPR-Cas9-based epigenome editing

    Sanjit Singh Batra, Alan Cabrera ... Yun S Song
    Machine learning models reveal that histone marks are predictive of gene expression across human cell types and highlight important nuances between natural control and the effects of CRISPR-Cas9-based epigenome editing.
    1. Neuroscience
    2. Computational and Systems Biology

    Motor biases reflect a misalignment between visual and proprioceptive reference frames

    Tianhe Wang, Ryan J Morehead ... Jonathan S Tsay
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Computational and Systems Biology
    2. Neuroscience

    Reconstructing voice identity from noninvasive auditory cortex recordings

    Charly Lamothe, Etienne Thoret ... Pascal Belin
    A low-dimensional voice latent space derived from deep learning captures speaker-identity representations in the temporal voice areas and supports reconstruction of voices preserving identity information.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Atypical collective oscillatory activity in cardiac tissue uncovered by optogenetics

    Alexander S Teplenin, Nina N Kudryashova ... Tim De Coster
    Collective frequency-selective resonance in depolarised cardiac tissue enables reversible switching between quiescent and ectopic oscillations through hidden bi-stability, which is shaped by light intensity, illuminated area, and pacing frequency.