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    1. Microbiology and Infectious Disease

    Efficacy and mechanism of action of cipargamin as an antibabesial drug candidate

    Hang Li, Shengwei Ji ... Xuenan Xuan
    The potential of repurposing cipargamin for treating Babesia species offers both theoretical advancements and practical applications in combating parasitic infections.
    1. Microbiology and Infectious Disease

    Salmonella exploits host- and bacterial-derived β-alanine for replication inside host macrophages

    Shuai Ma, Bin Yang ... Lingyan Jiang
    Salmonella orchestrates synergistic exploitation of host- and bacterial-derived β-alanine enhancing ZnuABC-mediated zinc assimilation to drive intracellular replication and systemic infection.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Deletion of the moeA gene in Flavobacterium IR1 drives structural color shift from green to blue and alters polysaccharide metabolism

    Álvaro Escobar Doncel, Constantinos Patinios ... Colin J Ingham
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Microbiology and Infectious Disease

    A SHERLOCK toolbox for the eco-epidemiological surveillance of animal African trypanosomosis reveals a similar parasite diversity in domestic pigs in two ancient sleeping sickness foci in Western Africa

    Roger-Junior Eloiflin, Elena Pérez-Antón ... Brice Rotureau
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Microbiology and Infectious Disease

    Stumpy forms are the predominant transmissible forms of Trypanosoma brucei

    Jean Marc Tsagmo Ngoune, Parul Sharma ... Brice Rotureau
    According to experimental and field observations, stumpy forms appear to be the most adapted forms for African trypanosome transmission from the mammalian host to the tsetse fly in natural conditions.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    CARD8 inflammasome activation during HIV-1 cell-to-cell transmission

    Jessie Kulsuptrakul, Michael Emerman, Patrick S Mitchell
    During cell-to-cell spread, HIV-1 protease activity triggers CARD8 inflammasome activation and IL-1β release from macrophages, which may contribute to inflammation and chronic immune activation.
    1. Microbiology and Infectious Disease

    Function and firing of the Streptomyces coelicolor contractile injection system requires the membrane protein CisA

    Bastien Casu, Joseph W Sallmen ... Susan Schlimpert
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Microbiology and Infectious Disease

    The increase in cell volume and nuclear number of the koji-fungus Aspergillus oryzae contributes to its high enzyme productivity

    Ayaka Itani, Haruto Motomura ... Norio Takeshita
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Microbiology and Infectious Disease

    Caffeic acid phenethyl ester protects Clostridioides difficile infection by toxin inhibition and microbiota modulation

    Yan Guo, Yong Zhang ... Jiazhang Qiu
    Caffeic acid phenethyl ester treats Clostridioides difficile infection by neutralizing Clostridioides difficile toxin B and altering the gut microbiota and metabolites.
    1. Microbiology and Infectious Disease

    A within-host infection model to explore tolerance and resistance

    David Duneau, Pierre DM Lafont ... Jean-Baptiste Ferdy
    A mathematical model of pathogen within-host dynamics and experimental validations elucidates the interplay between immune response, damage and pathogen proliferation, highlighting the limitations of current experimental proxies and proposing new methods to better understand host resistance and disease tolerance.
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