Browse our latest Microbiology and Infectious Disease articles

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    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Molecular mechanism of complement inhibition by the trypanosome receptor ISG65

    Alexander D Cook, Mark Carrington, Matthew K Higgins
    A structure derived from cryogenic electron microscopy shows how ISG65, an African trypanosome receptor that aids virulence, binds C3b and suggests mechanisms through which ISG65 might aid complement resistance.
    1. Microbiology and Infectious Disease

    Tools and methods for high-throughput single-cell imaging with the mother machine

    Ryan Thiermann, Michael Sandler ... Suckjoon Jun
    A user-friendly pipeline for analysis of time-lapse imaging data from the microfluidic mother machine.
    1. Microbiology and Infectious Disease

    High-risk Escherichia coli clones that cause neonatal meningitis and association with recrudescent infection

    Nguyen Thi Khanh Nhu, Minh-Duy Phan ... Mark A Schembri
    E. coli that cause neonatal meningitis largely derive from two global clonal lineages that can additionally form intestinal reservoirs to seed recrudescent invasive infection even when appropriate antibiotics are used.
    1. Microbiology and Infectious Disease

    Multi-tiered actions of Legionella effectors to modulate host Rab10 dynamics

    Tomoko Kubori, Kohei Arasaki ... Hiroki Nagai
    1. Microbiology and Infectious Disease

    A remarkable genetic shift in a transmitted/founder virus broadens antibody responses against HIV-1

    Swati Jain, Gherman Uritskiy ... Venigalla B Rao
    HIV escapes human immune pressure through a single mutation in V2 domain of envelope protein leading to emergence of mutant-specific broadly reactive antibodies, a phenomenon recapitulated in combinatorial vaccine design.
    1. Microbiology and Infectious Disease

    A myristoyl switch at the plasma membrane triggers cleavage and oligomerization of Mason-Pfizer monkey virus matrix protein

    Markéta Častorálová, Jakub Sýs ... Tomas Ruml
    Biochemical and instrumental analysis showed that the membrane-induced exposure of myristoyl from the MA protein of Mason-Pfizer monkey virus triggers allosteric conformational changes resulting in MA oligomerization and unfolding of the cleavage site between MA and downstream domains of Gag.
    1. Microbiology and Infectious Disease

    A Modified BPaL Regimen for Tuberculosis Treatment replaces Linezolid with Inhaled Spectinamides

    Malik Zohaib Ali, Taru S. Dutt ... Mercedes Gonzalez-Juarrero