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18,681 results found
    1. Neuroscience

    Hugin-AstA circuitry is a novel central energy sensor that directly regulates sweet sensation in Drosophila and mouse

    Wusa Qin, Tingting Song ... Rui Huang
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Microbiology and Infectious Disease

    An abundant merozoite surface protein of Plasmodium falciparum modulates susceptibility to inhibitory antibodies

    Isabelle G Henshall, Jill Chmielewski ... Danny W Wilson
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Computational and Systems Biology
    2. Evolutionary Biology

    An interpretable neural network unveils higher-order epistasis in large protein sequence-function relationships

    Palash Sethi, Juannan Zhou
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Immunology and Inflammation
    2. Evolutionary Biology

    Separating selection from mutation in antibody language models

    Frederick A Matsen, Will Dumm ... Hugh K Haddox
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Neuroscience

    The dominance of large-scale phase dynamics in human cortex, from delta to gamma

    David M Alexander, Laura Dugué
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Solid
    1. Neuroscience
    2. Physics of Living Systems

    “What” × “When” working memory representations using Laplace Neural Manifolds

    Aakash Sarkar, Shangfu Zuo ... Marc W Howard
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Biochemistry and Chemical Biology

    Concatenated modular BK channel constructs reveal divergent stoichiometry in gating control by LRRC26 (γ1), pore, and selectivity filter

    Guanxing Chen, Qin Li ... Jiusheng Yan
    Regulatory stoichiometry in large-conductance potassium (BK) channels diverges by mechanism, separating single-subunit activation, graded pore contributions, and collective selectivity-filter control.
    1. Neuroscience

    High-fidelity neural speech reconstruction through an efficient acoustic-linguistic dual-pathway framework

    Jiawei Li, Chunxu Guo ... Yuanning Li
    Concurrent decoding of acoustic detail and linguistic structure enables natural, intelligible speech synthesis from limited human cortical recordings, resolving a fundamental constraint in neural speech reconstruction.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Deep mutational scanning reveals pharmacologically relevant insights into TYK2 signaling and disease

    Conor J Howard, Nathan S Abell ... Diane E Dickel
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Microbiology and Infectious Disease

    Fine-tuning of outer membrane–peptidoglycan tethering by the redox-active lipoprotein LppB from Salmonella enterica

    Elisa S Pierre Despas, Seung-Hyun Cho ... Jean-François Collet
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Solid
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