Browse the latest research

19,346 results found
    1. Evolutionary Biology

    Class-wide sequence, structural, and docking-profile diversity of insect odorant receptors and structural specialization of Orco

    Tianmin Zhang, Xuanxiao Yang ... Huimeng Lu
    A large-scale comparative analysis reveals extensive diversity of insect odorant receptors and identifies a conserved extracellular β-sheet in Orco that helps restrict natural odorant access.
    1. Cancer Biology

    Impacts of mutation accumulation and order on tumor initiation revealed by engineered murine colorectal cancer organoids

    Yanping Li, Xiaoxin Xie ... Qionghua Zhu
    The temporal order of driver mutations influences colorectal cancer initiation in an immune-dependent manner, highlighting tumor–immune interactions as a context for evolutionary selection.
    1. Cell Biology
    2. Neuroscience

    A validated antibody toolbox for ALS research

    Riham Ayoubi, Emma J MacDougall ... Carl Laflamme
    A systematic characterization of antibodies targeting amyotrophic lateral sclerosis-associated proteins establishes a community resource for reliable protein detection and disease research.
    1. Neuroscience

    Number, order and time influence how the brain integrates distinct experiences

    Alina B Thomas, Francesca S Wong ... Nathan M Holmes
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Pain is so close to pleasure: the same dopamine neurons can mediate approach and avoidance in Drosophila

    Daniel Döringer, Christian Rohrsen ... Björn Brembs
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    The psychedelic DOI decreases the modularity of the cortical network by increasing cortico-cortical and thalamo-cortical functional influence

    Roman Doronin, Eduard Stroukov, Georg B Keller
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Context makes the difference: Temporally Resolved Dopaminergic Teaching Signals Shape Associative Memory in Drosophila Larvae

    Denise Weber, Anna-Maria Jürgensen ... Andreas S Thum
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Neuroscience

    Correlative light–electron microscopy reveals fundamentally different axonal architectures for fast and modulatory transmission

    Kok-Sin Lee, Daniela A Sahlender ... Graham W Knott
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Ecology

    Extinction risk in terrestrial vertebrates is associated with niche limits that reflect climatic vulnerability

    Matthew Nagy-Watson, Jeremy T Kerr
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Computational and Systems Biology
    2. Cancer Biology

    Heterogeneous, population-level drug-tolerant persisters exhibit ion-channel remodeling and ferroptosis susceptibility

    Corey E Hayford, Blake Baleami ... Leonard A Harris
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid

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