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19,278 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Distal conformational steering by N-terminal pyroglutamylation enables subtype-selective GPCR activation across Aplysia PRXamide and human Neuromedin U signaling

    Jian-Hui Chang, Wei-Jia Liu ... Jian Jing
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete
    1. Neuroscience

    Longitudinal Central Adiposity Accumulation is Associated with Cortical Alteration and Impaired Cognitive Function in Adolescents

    Lingxuan Zhang, Bowen Qiu ... Dan Wu
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Computational and Systems Biology

    A real-time, multi-animal model for automatic face detection and identification of freely moving common marmosets based on YOLOv8 algorithms

    Jiayue Yang, James Wang, Justine Cléry
    A generalizable computational approach automatically identifies individual common marmosets to serve as support for presenting and analyzing behavioral tasks without relying on extensive manual work.
    1. Neuroscience

    Dissociable roles of reward prediction error in the contrasting mood dynamics of depression and anxiety

    Zhihao Wang, Ting Wang ... Pengfei Xu
    Depression-specific symptoms blunt mood responses to unexpected outcomes, whereas anxiety-specific symptoms amplify them in non-clinical participants, with depression-related blunting also replicated in patients with affective disorders.
    1. Neuroscience

    PKD2L1 channels segregated to the apical compartment are the dual-mode pH sensor in cerebrospinal fluid-contacting neurons

    Magdalena Vitar, Daniel Prieto ... Federico F Trigo
    Apical PKD2L1 channels generate phasic and sustained currents that together make spinal cerebrospinal fluid-contacting neurons exquisite pH sensors.
    1. Computational and Systems Biology
    2. Developmental Biology

    Single-cell spatial mapping reveals reproducible cell type organization and spatially dependent gene expression in gastruloids

    Catherine Triandafillou, Pranav Sompalle ... Arjun Raj
    Detailed, single-cell spatial gene expression across multiple gastruloids highlights macro-scale organizational consistency, simultaneous with variance in meso-scale patterning.
    1. Plant Biology

    The petal identity gene PhDEF has a major binding and regulatory action in the epidermis

    Emma Désert, Quentin Cavallini-Speisser ... Marie Monniaux
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology

    HAX1 drives assembly and activation of the mitochondrial intermembrane space chaperone CLPB

    Monifa AV Fahie, Julia G Hoffman ... Julia R Kardon
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Microbiology and Infectious Disease

    Lactylation of Influenza Virus Polymerase Acidic Protein Promotes Viral Replication and Pathogenicity

    Shaoyu Tu, Yue Du ... Hongbo Zhou
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Reduced dorsal CA1 Activity Limits Retention of the Temporal Component of Declarative Memory in the Cntnap2 Knockout Mouse Model of Autism

    Elise C Rawlinson, Michael H McCullough ... Nathalie Dehorter
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
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