Browse the latest research

19,096 results found
    1. Medicine
    2. Immunology and Inflammation

    TLR4 signaling drives tissue inflammation, Claudin-5 internalization, and vascular barrier breakdown in a mouse model of neonatal meningitis

    Philip V Seegren, Amir Rattner ... Jeremy Nathans
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Computational and Systems Biology

    Permute-match tests detect significant correlations between time series despite nonstationarity and limited replicates

    Alex E Yuan, Wenying Shou
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Medicine

    Mid-zone hepatocytes trade proliferation for survival via Atf4-Chop axis in early acute liver injury

    Yaying Zhu, Chengxiang Deng ... Zhao Shan
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Incomplete
    1. Developmental Biology

    Junctional β-Catenin Stabilization Links Wnt Signaling and Force Generation

    Agimaa Otgonbaatar, Sujithra Shankar ... Nicholas S Tolwinski
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Neuroscience

    Thalamo-accumbal circuit adaptations following extended oxycodone abstinence

    Yanaira Alonso-Caraballo, Yan Li ... Elena H Chartoff
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Compelling
    1. Immunology and Inflammation

    ITK Deficiency Attenuates Alveolar Hemorrhage by Enhancing Regulatory T Cell-Mediated Tissue Resilience

    Mohammad Saddam Hossain, Ali Mobeen ... Mobin Karimi
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Identifying molecular instructions to hard-wire a sensory neuron’s synaptic connectivity

    Júnia Vieira dos Santos, Renee Yin Yu ... Brian E Chen
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Cell Biology

    CROP2, a Retriever–PROPPIN complex mediating protein export from endosomes to the plasma membrane in human cells

    Maria Giovanna De Leo, Andreas Mayer
    Endosomes operate several exit routes that sort protein cargo and depend on pathway-specific associations of a PROPPIN with the responsible protein coat, such as the here identified CROP2, to support the departure of the cargo carriers.
    1. Medicine

    Evaluating the applicability of replication success metrics in animal-to-human translation: A simulation study

    Carolyne Jie Huang, Samuel Pawel ... Rachel Heyard
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Excitation–inhibition balance controls coupling stability and network reorganization in a plastic Kuramoto model

    Satoshi Kuroki, Kenji Mizuseki
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
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