Biochemistry and Chemical Biology

Biochemistry and Chemical Biology

eLife reviews research that gives new insights into biological molecules or uses chemical approaches to illuminate complex biological processes. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Biochemistry and Chemical Biology

    Balanced Interplay Between Hsp110, Hsp70 and Class B J-Domain Protein Improves Aggregate Disassembly

    Wiktoria Sztangierska, Hubert Wyszkowski ... Agnieszka Kłosowska
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The catalytic mechanism of the RNA methyltransferase METTL3

    Ivan Corbeski, Pablo Andrés Vargas-Rosales ... Amedeo Caflisch
    A multidisciplinary study reveals the reaction mechanism and transition state of adenosine-N6 methyl transfer catalyzed by human METTL3-14, deepening our insight into RNA methyltransferases and paving the way for similar studies on related enzymes.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Imidacloprid disrupts larval molting regulation and nutrient energy metabolism, causing developmental delay in honey bee Apis mellifera

    Zhi Li, Yuedi Wang ... Zeyang Zhou
    Molecular and biochemical methods provide the first evidence of toxicity of imidacloprid causing developmental retardation in honeybee larvae, highlighting the potential risks of prolonged exposure to insecticides during animal development.