Biochemistry and Chemical Biology

Biochemistry and Chemical Biology

eLife reviews research that gives new insights into biological molecules or uses chemical approaches to illuminate complex biological processes. Learn more about what we review and sign up for the latest research.
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Latest articles

    1. Biochemistry and Chemical Biology
    2. Physics of Living Systems

    Microscopic PhotoSelection (MiPS) of single cells in mother machine microfluidic devices

    Jessica James, Idris Kempf ... Harrison Steel
    Not revised
    Reviewed Preprint v1
    • Useful
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Ecology

    Planetary-scale heterotrophic microbial community modeling assesses metabolic synergy and viral impacts

    Antoine Régimbeau, Funing Tian ... Damien Eveillard
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Biochemistry and Chemical Biology

    Integrated Respirometry and Metabolomics Unveil Circadian Metabolic Dynamics in Drosophila

    Farheen Akhtar, Dania Malik ... Aalim M Weljie
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology

    A whole-animal phenotypic drug screen identifies suppressors of atherogenic lipoproteins

    Daniel J Kelpsch, Liyun Zhang ... Steven A Farber
    An in vivo small-molecule drug screen in developing zebrafish larvae identifies dozens of unique chemical modulators capable of reducing atherogenic apolipoprotein B levels.
    1. Biochemistry and Chemical Biology

    Cell cycle-coupled CK1δ turnover, autoinhibition, and activity

    Fidel E Serrano, Bianca Ruppert ... Michael Brunner
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Macrodomain catalytic activity modulates Chikungunya virus dissemination and transmission potential in Aedes mosquitoes

    Eugenia S Bardossy, Lena Bergmann ... Maria-Carla Saleh
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Acyl Carrier Protein is Essential for Apicoplast Biogenesis in Malaria Parasites Independent of Fatty Acid Synthesis

    Sage WR Geher, Seyi Falekun ... Paul A Sigala
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Identifying Novel Estrogenic Mitochondrial Targets in Hypothalamic Proopiomelanocortin Neurons by Chemoproteomics

    Jian Qiu, Martha A Bosch ... Martin J Kelly
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Gβγ engages PLCβ3 at multiple sites to reorient and facilitate its activation

    Isaac J Fisher, Kanishka Senarath ... Angeline M Lyon
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology

    A simplified and highly efficient cell-free protein synthesis system for prokaryotes

    Xianshengjie Lang, Changbin Zhang ... Wenfei Li
    Revised
    Reviewed Preprint v4
    Updated
    • Valuable
    • Convincing
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Highlights

    1. Biochemistry and Chemical Biology

    Lipid Transport: How membranes shape up for lipid transfer

    Takashi Hirashima, Toshiya Endo
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Metabolism: How one nutrient controls cell size

    Angela Montero, Lydia WS Finley
    1. Biochemistry and Chemical Biology

    RNA: Searching for druggable targets

    Lana Heganovic, Luiz FM Passalacqua

Senior editors

  1. Qiang Cui
    Boston University, United States
  2. Volker Dötsch
    Goethe University, Germany
  3. Dominique Soldati-Favre
    University of Geneva, Switzerland
  4. See more editors