Biochemistry and Chemical Biology

Biochemistry and Chemical Biology

eLife reviews research that gives new insights into biological molecules or uses chemical approaches to illuminate complex biological processes. Learn more about what we review and sign up for the latest research.
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Latest articles

    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Gβγ engages PLCβ3 at multiple sites to reorient and facilitate its activation

    Isaac J Fisher, Kanishka Senarath ... Angeline M Lyon
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Natural xanthones as α-Mangostin induce vasorelaxation involving key gating residues in the S6 domain of BK channels

    Sönke Cordeiro, Robert Patejdl ... Marianne Musinszki
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Biochemistry and Chemical Biology

    Distinct mechanisms of inhibition of Kv2 potassium channels by tetraethylammonium and RY785

    Shan Zhang, Robyn Stix ... José D Faraldo-Gómez
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Investigating the native functions of [NiFe]-CODH through genomic context analysis

    Maximilian Böhm, Henrik Land
    Genomic neighborhood signatures delineate catalytic versus putative regulatory CODH clades, establishing a framework for predicting enzyme functionality and guiding discovery of biocatalysts for CO2 reduction.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Transforming a fragile protein helix into an ultrastable scaffold via a hierarchical AI and chemistry framework

    Jun Qiu, Guojin Tang ... Peng Zheng
    A hierarchical framework integrating artificial intelligence with chemical principles enables the conversion of fragile α-helices into ultrastable protein scaffolds.
    1. Biochemistry and Chemical Biology

    Membrane curvature regulates Ups1 dependent phosphatidic acid transfer across lipid bilayers

    Fereshteh Sadeqi, Dexin Dong ... Michael Meinecke
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    DNA tensiometer reveals catch-bond detachment kinetics of kinesin-1, -2 and -3

    Crystal R Noell, Tzu-Chen Ma ... William O Hancock
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Convincing
    1. Biochemistry and Chemical Biology

    In search of nonlipogenic ABCA1 inducers (NLAI): precision coregulator TR-FRET identifies diverse signatures for LXR ligands

    Megan S Laham, Martha Ackerman-Berrier ... Gregory RJ Thatcher
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    NAD boosting mediated by CD38 inhibition drives reversal of a pathological vicious cycle of intracrine activity and inflammation in eyelid meibomian gland dysfunction

    Yuki Hamada, Takehide Sakamoto ... Masao Doi
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Biochemistry and Chemical Biology

    Stall force measurement of the kinesin-3 motor KIF1A using a programmable DNA origami nanospring

    Nobumichi Takamatsu, Hiroko Furumoto ... Kumiko Hayashi
    A DNA origami nanospring introduces a force-sensing technology that enables measurement of motor protein stall forces without optical trapping, detecting force changes in kinesin KIF1A and its disease-related mutants.
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Highlights

    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Metabolism: How one nutrient controls cell size

    Angela Montero, Lydia WS Finley
    1. Biochemistry and Chemical Biology

    RNA: Searching for druggable targets

    Lana Heganovic, Luiz FM Passalacqua
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Cellular Energy Production: Mycofactocin and the mycobacterial electron transport chain

    Stephanie M Stuteley, Ghader Bashiri

Senior editors

  1. Amy H Andreotti
    Iowa State University, United States
  2. Qiang Cui
    Boston University, United States
  3. Merritt Maduke
    Stanford University School of Medicine, United States
  4. See more editors