Structural Biology and Molecular Biophysics

Latest articles

1. 1. Structural Biology and Molecular Biophysics

   Wide Transition-State Ensemble as Key Component for Enzyme Catalysis

   Gabriel Ernesto Jara, Francesco Pontiggia ... Dorothee Kern
2. 1. Structural Biology and Molecular Biophysics

   Interaction of GAT1 with sodium ions: from efficient recruitment to stabilisation of substrate and conformation

   Erika Lazzarin, Ralph Gradisch ... Thomas Stockner
3. 1. Structural Biology and Molecular Biophysics

   A cryo-ET study of ciliary rootlet organization

   Chris van Hoorn, Andrew P. Carter
4. 1. Structural Biology and Molecular Biophysics

   A parameterized two-domain thermodynamic model explains diverse mutational effects on protein allostery

   Zhuang Liu, Thomas G Gillis ... Qiang Cui

   A combined theoretical and experimental study revealed the mechanistic and structural basis of mutational effects on allostery and provided insights into the intrinsic connection of intra- and inter-domain properties.
5. 1. Structural Biology and Molecular Biophysics

   An Integrated Machine Learning Approach Delineates Entropy-mediated Conformational Modulation of α-synuclein by Small Molecule

   Sneha Menon, Subinoy Adhikari, Jagannath Mondal
6. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Ligand Response of Guanidine-IV riboswitch at Single-molecule Level

   Lingzhi Gao, Dian Chen, Yu Liu
7. 1. Structural Biology and Molecular Biophysics

   Mechanism of Dimer Selectivity and Binding Cooperativity of BRAF Inhibitors

   Joseph Clayton, Aarion Romany ... Jana Shen
8. 1. Structural Biology and Molecular Biophysics

   Structures of wild-type and a constitutively closed mutant of connexin26 shed light on channel regulation by CO₂

   Deborah H Brotherton, Sarbjit Nijjar ... Alexander David Cameron

   The mutation of Lys125 in connexin26 to glutamate, a carbamylation mimetic, pushes the equilibrium of the gap junction channel seen in cryo-EM towards a more closed conformation.
9. 1. Microbiology and Infectious Disease
   2. Structural Biology and Molecular Biophysics

   Bacterial vampirism mediated through taxis to serum

   Siena J Glenn, Zealon Gentry-Lear ... Arden Baylink

   Enteric bacteria associated with bloodstream infections are attracted to human serum through L-serine and the chemoreceptor Tsr, and in an enterohemorrhagic lesion model use chemotaxis to invade damaged vasculature.
10. 1. Structural Biology and Molecular Biophysics

    Signaling: The tale of capturing Norrin

    Hsin-Yi Henry Ho

    Detailed binding experiments reveal new insights into the Norrin/Wnt signaling pathway that helps to control vascularization in the retina.