Structural Biology and Molecular Biophysics

Latest articles

1. 1. Structural Biology and Molecular Biophysics

   Targeted anticancer pre-vinylsulfone covalent inhibitors of carbonic anhydrase IX

   Aivaras Vaškevičius, Denis Baronas ... Daumantas Matulis
2. 1. Structural Biology and Molecular Biophysics

   The Arthropoda-specific Tramtrack group BTB protein domains use previously unknown interface to form hexamers

   Artem N Bonchuk, Konstantin I Balagurov ... Pavel G Georgiev

   The cryo-EM structure of the CG6765 BTB domain and solution scattering experiments revealed a unique three-dimer hexameric assembly for the arthropod Tramtrack group BTB domains.
3. 1. Structural Biology and Molecular Biophysics

   Elucidating ATP’s Role as Solubilizer of Biomolecular Aggregate

   Susmita Sarkar, Saurabh Gupta ... Jagannath Mondal
4. 1. Structural Biology and Molecular Biophysics

   Cryo-EM structures of Kv1.2 potassium channels, conducting and non-conducting

   Yangyu Wu, Yangyang Yan ... Fred J Sigworth
5. 1. Structural Biology and Molecular Biophysics

   Cryo-electron tomographic investigation of native hippocampal glutamatergic synapses

   Aya Matsui, Cathy J Spangler ... Eric Gouaux
6. 1. Structural Biology and Molecular Biophysics
   2. Cell Biology

   Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells

   Affiong I Oqua, Kin Chao ... Alejandra Tomas
7. 1. Structural Biology and Molecular Biophysics

   Predicting the Sequence-Dependent Backbone Dynamics of Intrinsically Disordered Proteins

   Sanbo Qin, Huan-Xiang Zhou
8. 1. Structural Biology and Molecular Biophysics

   PUFA stabilizes a conductive state of the selectivity filter in IKs channels

   Alessia Golluscio, Jodene Eldstrom ... H Peter Larsson
9. 1. Structural Biology and Molecular Biophysics

   Exploring protein structural ensembles: Integration of sparse experimental data from electron paramagnetic resonance spectroscopy with molecular modeling methods

   Julia Belyaeva, Matthias Elgeti

   Complementing experimental data from EPR spectroscopy with computational modeling techniques provides access to protein structural dynamics and enables the characterization of rare protein conformations.
10. 1. Structural Biology and Molecular Biophysics

    PPI-hotspot^ID for detecting protein–protein interaction hot spots from the free protein structure

    Yao Chi Chen, Karen Sargsyan ... Carmay Lim

    PPI-hotspot^ID, trained using an automated machine-learning framework, AutoGluon, on the largest PPI-hot spot dataset to date, detects hot spots beyond protein–protein interfaces, uncovering druggable interactions to aid design of PPI-modulating therapeutics.